Code Sample, a copy-pastable example if possible
pandas 0.20.3

import pandas as pd
rng = pd.DataFrame({ "A" : pd.date_range('1/1/2011', periods=720, freq='H')})
myvar = rng["A"] < rng["A"].values[3]
Works.

pandas 0.21

exact same code:

I am not sure why this would fail now?
Note: it might be fixed in #18188