System.Data.Odbc has a big number of platform specific configurations. As those are now shipping as part of #53439, it might make sense to review and see if some of these configurations could be collapsed together.
System.Text.Encodings.Web targets a Browser even though it doesn't use any platform specific APIs. Apparently this is so that the linker can trim out Vector128 on browser-wasm: #53439 (comment). We should see if there's a better way to make this work without the platform specific configuration.
EDIT:
In addition to that, we need to make sure that all dependencies from the platform TFMs are represented in the platform agnostic TFM.
cc @ericstj @eerhardt @MichalStrehovsky @marek-safar @ajcvickers