Ran into an issue when trying to install CUDA using the Python from $EPREFIX:
== FAILED: Installation ended unsuccessfully (build directory: /tmp/CUDAcore/11.1.1/system-system): build failed (first 300 chars): Unexpected error occurred when trying to download https://developer.download.nvidia.com/compute/cuda/11.1.1/local_installers/cuda_11.1.1_455.32.00_linux.run to /project/def-sponsor00/easybuild/sources/c/CUDAcore/cuda_11.1.1_455.32.00_linux.run: signed integer is greater than maximum (took 0 sec)
It looks like this is a bug in Python 3.8 (from https://bugs.python.org/issue42853)