diff --git a/drivers/i2c/i2c_mcux_lpi2c_rtio.c b/drivers/i2c/i2c_mcux_lpi2c_rtio.c
index f267b7ada4ce1..a4ac9a2f20c38 100644
--- a/drivers/i2c/i2c_mcux_lpi2c_rtio.c
+++ b/drivers/i2c/i2c_mcux_lpi2c_rtio.c
@@ -16,6 +16,9 @@
 #include <zephyr/kernel.h>
 #include <zephyr/irq.h>
 #include <fsl_lpi2c.h>
+#if CONFIG_NXP_LP_FLEXCOMM
+#include <zephyr/drivers/mfd/nxp_lp_flexcomm.h>
+#endif
 
 #include <zephyr/drivers/pinctrl.h>
 
@@ -280,7 +283,11 @@ static void mcux_lpi2c_isr(const struct device *dev)
 	struct mcux_lpi2c_data *data = dev->data;
 	LPI2C_Type *base = (LPI2C_Type *)DEVICE_MMIO_NAMED_GET(dev, reg_base);
 
+#if CONFIG_HAS_MCUX_FLEXCOMM
+	LPI2C_MasterTransferHandleIRQ(LPI2C_GetInstance(base), &data->handle);
+#else
 	LPI2C_MasterTransferHandleIRQ(base, &data->handle);
+#endif
 }
 
 static int mcux_lpi2c_init(const struct device *dev)
@@ -346,10 +353,41 @@ static DEVICE_API(i2c, mcux_lpi2c_driver_api) = {
 #define I2C_MCUX_LPI2C_SDA_INIT(n)
 #endif /* CONFIG_I2C_MCUX_LPI2C_BUS_RECOVERY */
 
+#define I2C_MCUX_LPI2C_MODULE_IRQ_CONNECT(n)				\
+	do {								\
+		IRQ_CONNECT(DT_INST_IRQN(n),				\
+			DT_INST_IRQ(n, priority),			\
+			mcux_lpi2c_isr,					\
+			DEVICE_DT_INST_GET(n), 0);			\
+		irq_enable(DT_INST_IRQN(n));				\
+	} while (false)
+
+#define I2C_MCUX_LPI2C_MODULE_IRQ(n)					\
+	IF_ENABLED(DT_INST_IRQ_HAS_IDX(n, 0),				\
+		(I2C_MCUX_LPI2C_MODULE_IRQ_CONNECT(n)))
+
+/* When using LP Flexcomm driver, register the interrupt handler
+ * so we receive notification from the LP Flexcomm interrupt handler.
+ */
+#define I2C_MCUX_LPI2C_LPFLEXCOMM_IRQ_FUNC(n)				\
+	nxp_lp_flexcomm_setirqhandler(DEVICE_DT_GET(DT_INST_PARENT(n)), \
+					DEVICE_DT_INST_GET(n),		\
+					LP_FLEXCOMM_PERIPH_LPI2C,	\
+					mcux_lpi2c_isr)
+
+#define I2C_MCUX_LPI2C_IRQ_SETUP_FUNC(n)				\
+	COND_CODE_1(DT_NODE_HAS_COMPAT(DT_INST_PARENT(n),		\
+					nxp_lp_flexcomm),		\
+		    (I2C_MCUX_LPI2C_LPFLEXCOMM_IRQ_FUNC(n)),		\
+		    (I2C_MCUX_LPI2C_MODULE_IRQ(n)))
+
 #define I2C_MCUX_LPI2C_INIT(n)						\
 	PINCTRL_DT_INST_DEFINE(n);					\
 									\
-	static void mcux_lpi2c_config_func_##n(const struct device *dev); \
+	static void mcux_lpi2c_config_func_##n(const struct device *dev)\
+	{								\
+		I2C_MCUX_LPI2C_IRQ_SETUP_FUNC(n);			\
+	}								\
 									\
 	static const struct mcux_lpi2c_config mcux_lpi2c_config_##n = {	\
 		DEVICE_MMIO_NAMED_ROM_INIT(reg_base, DT_DRV_INST(n)),	\
@@ -378,16 +416,6 @@ static DEVICE_API(i2c, mcux_lpi2c_driver_api) = {
 				&mcux_lpi2c_data_##n,			\
 				&mcux_lpi2c_config_##n, POST_KERNEL,	\
 				CONFIG_I2C_INIT_PRIORITY,		\
-				&mcux_lpi2c_driver_api);		\
-									\
-	static void mcux_lpi2c_config_func_##n(const struct device *dev)\
-	{								\
-		IRQ_CONNECT(DT_INST_IRQN(n),				\
-				DT_INST_IRQ(n, priority),		\
-				mcux_lpi2c_isr,				\
-				DEVICE_DT_INST_GET(n), 0);		\
-									\
-		irq_enable(DT_INST_IRQN(n));				\
-	}
+				&mcux_lpi2c_driver_api);
 
 DT_INST_FOREACH_STATUS_OKAY(I2C_MCUX_LPI2C_INIT)