diff --git a/CHANGES b/CHANGES
index 3df48ab62e0..c15f969bc56 100644
--- a/CHANGES
+++ b/CHANGES
@@ -4,6 +4,21 @@
 
 - _Insert changes/features/fixes for next release here_
 
+#### Packaging
+
+- `poetry build` used to package in place of `python setup.py build` (#729)
+
+  Package maintainers: If you run into any issues at
+  [#625](https://github.com/tmux-python/tmuxp/issues/625).
+
+  Additionally, `libtmux` has been pinned to a similar release at
+  [0.10.3](https://pypi.org/project/libtmux/0.10.3/) which has used the new
+  build process.
+
+- `poetry publish` instead of `twine upload dist/*` (#729)
+
+  Similar to the above, reach out to the #625 issue if you bump into problems.
+
 #### What's new
 
 - `tmuxp edit` for configuration changes (#707, @GlebPoljakov)
@@ -13,6 +28,7 @@
   Inside a project: `tmuxp edit .`
 
 ### Removed support
+
 - Python 3.6 support has been removed (#726)
 
 ### Development
diff --git a/poetry.lock b/poetry.lock
index 0c41282a9ec..ac31b7d79fd 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -86,17 +86,34 @@ python2 = ["typed-ast (>=1.4.3)"]
 uvloop = ["uvloop (>=0.15.2)"]
 
 [[package]]
-name = "bleach"
-version = "4.1.0"
-description = "An easy safelist-based HTML-sanitizing tool."
+name = "cachecontrol"
+version = "0.12.10"
+description = "httplib2 caching for requests"
 category = "dev"
 optional = false
 python-versions = ">=3.6"
 
 [package.dependencies]
-packaging = "*"
-six = ">=1.9.0"
-webencodings = "*"
+lockfile = {version = ">=0.9", optional = true, markers = "extra == \"filecache\""}
+msgpack = ">=0.5.2"
+requests = "*"
+
+[package.extras]
+filecache = ["lockfile (>=0.9)"]
+redis = ["redis (>=2.10.5)"]
+
+[[package]]
+name = "cachy"
+version = "0.3.0"
+description = "Cachy provides a simple yet effective caching library."
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+
+[package.extras]
+redis = ["redis (>=3.3.6,<4.0.0)"]
+memcached = ["python-memcached (>=1.59,<2.0)"]
+msgpack = ["msgpack-python (>=0.5,<0.6)"]
 
 [[package]]
 name = "certifi"
@@ -128,6 +145,17 @@ python-versions = ">=3.5.0"
 [package.extras]
 unicode_backport = ["unicodedata2"]
 
+[[package]]
+name = "cleo"
+version = "0.8.1"
+description = "Cleo allows you to create beautiful and testable command-line interfaces."
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+
+[package.dependencies]
+clikit = ">=0.6.0,<0.7.0"
+
 [[package]]
 name = "click"
 version = "8.0.3"
@@ -140,6 +168,19 @@ python-versions = ">=3.6"
 colorama = {version = "*", markers = "platform_system == \"Windows\""}
 importlib-metadata = {version = "*", markers = "python_version < \"3.8\""}
 
+[[package]]
+name = "clikit"
+version = "0.6.2"
+description = "CliKit is a group of utilities to build beautiful and testable command line interfaces."
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+
+[package.dependencies]
+crashtest = {version = ">=0.3.0,<0.4.0", markers = "python_version >= \"3.6\" and python_version < \"4.0\""}
+pastel = ">=0.2.0,<0.3.0"
+pylev = ">=1.3,<2.0"
+
 [[package]]
 name = "codecov"
 version = "2.1.12"
@@ -174,9 +215,17 @@ tomli = {version = "*", optional = true, markers = "extra == \"toml\""}
 [package.extras]
 toml = ["tomli"]
 
+[[package]]
+name = "crashtest"
+version = "0.3.1"
+description = "Manage Python errors with ease"
+category = "dev"
+optional = false
+python-versions = ">=3.6,<4.0"
+
 [[package]]
 name = "cryptography"
-version = "35.0.0"
+version = "36.0.1"
 description = "cryptography is a package which provides cryptographic recipes and primitives to Python developers."
 category = "dev"
 optional = false
@@ -187,12 +236,20 @@ cffi = ">=1.12"
 
 [package.extras]
 docs = ["sphinx (>=1.6.5,!=1.8.0,!=3.1.0,!=3.1.1)", "sphinx-rtd-theme"]
-docstest = ["doc8", "pyenchant (>=1.6.11)", "twine (>=1.12.0)", "sphinxcontrib-spelling (>=4.0.1)"]
+docstest = ["pyenchant (>=1.6.11)", "twine (>=1.12.0)", "sphinxcontrib-spelling (>=4.0.1)"]
 pep8test = ["black", "flake8", "flake8-import-order", "pep8-naming"]
 sdist = ["setuptools_rust (>=0.11.4)"]
 ssh = ["bcrypt (>=3.1.5)"]
 test = ["pytest (>=6.2.0)", "pytest-cov", "pytest-subtests", "pytest-xdist", "pretend", "iso8601", "pytz", "hypothesis (>=1.11.4,!=3.79.2)"]
 
+[[package]]
+name = "distlib"
+version = "0.3.4"
+description = "Distribution utilities"
+category = "dev"
+optional = false
+python-versions = "*"
+
 [[package]]
 name = "docutils"
 version = "0.17.1"
@@ -201,6 +258,18 @@ category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
+[[package]]
+name = "filelock"
+version = "3.4.2"
+description = "A platform independent file lock."
+category = "dev"
+optional = false
+python-versions = ">=3.7"
+
+[package.extras]
+docs = ["furo (>=2021.8.17b43)", "sphinx (>=4.1)", "sphinx-autodoc-typehints (>=1.12)"]
+testing = ["covdefaults (>=1.2.0)", "coverage (>=4)", "pytest (>=4)", "pytest-cov", "pytest-timeout (>=1.4.2)"]
+
 [[package]]
 name = "flake8"
 version = "4.0.1"
@@ -215,6 +284,24 @@ mccabe = ">=0.6.0,<0.7.0"
 pycodestyle = ">=2.8.0,<2.9.0"
 pyflakes = ">=2.4.0,<2.5.0"
 
+[[package]]
+name = "html5lib"
+version = "1.1"
+description = "HTML parser based on the WHATWG HTML specification"
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+
+[package.dependencies]
+six = ">=1.9"
+webencodings = "*"
+
+[package.extras]
+all = ["genshi", "chardet (>=2.2)", "lxml"]
+chardet = ["chardet (>=2.2)"]
+genshi = ["genshi"]
+lxml = ["lxml"]
+
 [[package]]
 name = "idna"
 version = "3.3"
@@ -233,19 +320,18 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
 
 [[package]]
 name = "importlib-metadata"
-version = "4.2.0"
+version = "1.7.0"
 description = "Read metadata from Python packages"
 category = "main"
 optional = false
-python-versions = ">=3.6"
+python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,>=2.7"
 
 [package.dependencies]
-typing-extensions = {version = ">=3.6.4", markers = "python_version < \"3.8\""}
 zipp = ">=0.5"
 
 [package.extras]
-docs = ["sphinx", "jaraco.packaging (>=8.2)", "rst.linker (>=1.9)"]
-testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "packaging", "pep517", "pyfakefs", "flufl.flake8", "pytest-black (>=0.3.7)", "pytest-mypy", "importlib-resources (>=1.3)"]
+docs = ["sphinx", "rst.linker"]
+testing = ["packaging", "pep517", "importlib-resources (>=1.3)"]
 
 [[package]]
 name = "iniconfig"
@@ -307,28 +393,36 @@ PyYAML = ">=3.13,<6"
 
 [[package]]
 name = "keyring"
-version = "23.2.1"
+version = "21.8.0"
 description = "Store and access your passwords safely."
 category = "dev"
 optional = false
 python-versions = ">=3.6"
 
 [package.dependencies]
-importlib-metadata = ">=3.6"
+importlib-metadata = {version = ">=1", markers = "python_version < \"3.8\""}
 jeepney = {version = ">=0.4.2", markers = "sys_platform == \"linux\""}
 pywin32-ctypes = {version = "<0.1.0 || >0.1.0,<0.1.1 || >0.1.1", markers = "sys_platform == \"win32\""}
 SecretStorage = {version = ">=3.2", markers = "sys_platform == \"linux\""}
 
 [package.extras]
 docs = ["sphinx", "jaraco.packaging (>=8.2)", "rst.linker (>=1.9)"]
-testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "pytest-black (>=0.3.7)", "pytest-mypy"]
+testing = ["pytest (>=3.5,!=3.7.3)", "pytest-checkdocs (>=1.2.3)", "pytest-flake8", "pytest-cov", "jaraco.test (>=3.2.0)", "pytest-black (>=0.3.7)", "pytest-mypy"]
 
 [[package]]
 name = "libtmux"
-version = "0.10.2"
+version = "0.10.3"
 description = "scripting library / orm for tmux"
 category = "main"
 optional = false
+python-versions = ">=3.7,<4.0"
+
+[[package]]
+name = "lockfile"
+version = "0.12.2"
+description = "Platform-independent file locking module"
+category = "dev"
+optional = false
 python-versions = "*"
 
 [[package]]
@@ -383,6 +477,14 @@ code_style = ["pre-commit (==2.6)"]
 rtd = ["myst-parser (>=0.14.0,<0.15.0)", "sphinx-book-theme (>=0.1.0,<0.2.0)"]
 testing = ["coverage", "pytest (>=3.6,<4)", "pytest-cov", "pytest-regressions"]
 
+[[package]]
+name = "msgpack"
+version = "1.0.3"
+description = "MessagePack (de)serializer."
+category = "dev"
+optional = false
+python-versions = "*"
+
 [[package]]
 name = "mypy-extensions"
 version = "0.4.3"
@@ -415,14 +517,22 @@ testing = ["beautifulsoup4", "coverage", "docutils (>=0.17.0,<0.18.0)", "pytest
 
 [[package]]
 name = "packaging"
-version = "21.2"
+version = "20.9"
 description = "Core utilities for Python packages"
 category = "dev"
 optional = false
-python-versions = ">=3.6"
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
 
 [package.dependencies]
-pyparsing = ">=2.0.2,<3"
+pyparsing = ">=2.0.2"
+
+[[package]]
+name = "pastel"
+version = "0.2.1"
+description = "Bring colors to your terminal."
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
 
 [[package]]
 name = "pathspec"
@@ -432,6 +542,17 @@ category = "dev"
 optional = false
 python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,>=2.7"
 
+[[package]]
+name = "pexpect"
+version = "4.8.0"
+description = "Pexpect allows easy control of interactive console applications."
+category = "dev"
+optional = false
+python-versions = "*"
+
+[package.dependencies]
+ptyprocess = ">=0.5"
+
 [[package]]
 name = "pillow"
 version = "8.4.0"
@@ -442,14 +563,14 @@ python-versions = ">=3.6"
 
 [[package]]
 name = "pkginfo"
-version = "1.7.1"
+version = "1.8.2"
 description = "Query metadatdata from sdists / bdists / installed packages."
 category = "dev"
 optional = false
 python-versions = "*"
 
 [package.extras]
-testing = ["nose", "coverage"]
+testing = ["coverage", "nose"]
 
 [[package]]
 name = "platformdirs"
@@ -478,6 +599,52 @@ importlib-metadata = {version = ">=0.12", markers = "python_version < \"3.8\""}
 dev = ["pre-commit", "tox"]
 testing = ["pytest", "pytest-benchmark"]
 
+[[package]]
+name = "poetry"
+version = "1.1.12"
+description = "Python dependency management and packaging made easy."
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+
+[package.dependencies]
+cachecontrol = {version = ">=0.12.9,<0.13.0", extras = ["filecache"], markers = "python_version >= \"3.6\" and python_version < \"4.0\""}
+cachy = ">=0.3.0,<0.4.0"
+cleo = ">=0.8.1,<0.9.0"
+clikit = ">=0.6.2,<0.7.0"
+crashtest = {version = ">=0.3.0,<0.4.0", markers = "python_version >= \"3.6\" and python_version < \"4.0\""}
+html5lib = ">=1.0,<2.0"
+importlib-metadata = {version = ">=1.6.0,<2.0.0", markers = "python_version < \"3.8\""}
+keyring = {version = ">=21.2.0,<22.0.0", markers = "python_version >= \"3.6\" and python_version < \"4.0\""}
+packaging = ">=20.4,<21.0"
+pexpect = ">=4.7.0,<5.0.0"
+pkginfo = ">=1.4,<2.0"
+poetry-core = ">=1.0.7,<1.1.0"
+requests = ">=2.18,<3.0"
+requests-toolbelt = ">=0.9.1,<0.10.0"
+shellingham = ">=1.1,<2.0"
+tomlkit = ">=0.7.0,<1.0.0"
+virtualenv = ">=20.0.26,<21.0.0"
+
+[[package]]
+name = "poetry-core"
+version = "1.0.7"
+description = "Poetry PEP 517 Build Backend"
+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+
+[package.dependencies]
+importlib-metadata = {version = ">=1.7.0,<2.0.0", markers = "python_version >= \"2.7\" and python_version < \"2.8\" or python_version >= \"3.5\" and python_version < \"3.8\""}
+
+[[package]]
+name = "ptyprocess"
+version = "0.7.0"
+description = "Run a subprocess in a pseudo terminal"
+category = "dev"
+optional = false
+python-versions = "*"
+
 [[package]]
 name = "py"
 version = "1.10.0"
@@ -496,7 +663,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
 [[package]]
 name = "pycparser"
-version = "2.20"
+version = "2.21"
 description = "C parser in Python"
 category = "dev"
 optional = false
@@ -518,6 +685,14 @@ category = "dev"
 optional = false
 python-versions = ">=3.5"
 
+[[package]]
+name = "pylev"
+version = "1.4.0"
+description = "A pure Python Levenshtein implementation that's not freaking GPL'd."
+category = "dev"
+optional = false
+python-versions = "*"
+
 [[package]]
 name = "pyparsing"
 version = "2.4.7"
@@ -612,22 +787,6 @@ category = "main"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*"
 
-[[package]]
-name = "readme-renderer"
-version = "30.0"
-description = "readme_renderer is a library for rendering \"readme\" descriptions for Warehouse"
-category = "dev"
-optional = false
-python-versions = "*"
-
-[package.dependencies]
-bleach = ">=2.1.0"
-docutils = ">=0.13.1"
-Pygments = ">=2.5.1"
-
-[package.extras]
-md = ["cmarkgfm (>=0.5.0,<0.7.0)"]
-
 [[package]]
 name = "requests"
 version = "2.26.0"
@@ -657,17 +816,6 @@ python-versions = "*"
 [package.dependencies]
 requests = ">=2.0.1,<3.0.0"
 
-[[package]]
-name = "rfc3986"
-version = "1.5.0"
-description = "Validating URI References per RFC 3986"
-category = "dev"
-optional = false
-python-versions = "*"
-
-[package.extras]
-idna2008 = ["idna"]
-
 [[package]]
 name = "secretstorage"
 version = "3.3.1"
@@ -680,6 +828,14 @@ python-versions = ">=3.6"
 cryptography = ">=2.0"
 jeepney = ">=0.6"
 
+[[package]]
+name = "shellingham"
+version = "1.4.0"
+description = "Tool to Detect Surrounding Shell"
+category = "dev"
+optional = false
+python-versions = "!=3.0,!=3.1,!=3.2,!=3.3,>=2.6"
+
 [[package]]
 name = "six"
 version = "1.16.0"
@@ -846,39 +1002,51 @@ optional = false
 python-versions = ">=3.6"
 
 [[package]]
-name = "tqdm"
-version = "4.62.3"
-description = "Fast, Extensible Progress Meter"
+name = "tomlkit"
+version = "0.8.0"
+description = "Style preserving TOML library"
 category = "dev"
 optional = false
-python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,>=2.7"
+python-versions = ">=3.6,<4.0"
+
+[[package]]
+name = "tox"
+version = "3.24.5"
+description = "tox is a generic virtualenv management and test command line tool"
+category = "dev"
+optional = false
+python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,>=2.7"
 
 [package.dependencies]
-colorama = {version = "*", markers = "platform_system == \"Windows\""}
+colorama = {version = ">=0.4.1", markers = "platform_system == \"Windows\""}
+filelock = ">=3.0.0"
+importlib-metadata = {version = ">=0.12", markers = "python_version < \"3.8\""}
+packaging = ">=14"
+pluggy = ">=0.12.0"
+py = ">=1.4.17"
+six = ">=1.14.0"
+toml = ">=0.9.4"
+virtualenv = ">=16.0.0,<20.0.0 || >20.0.0,<20.0.1 || >20.0.1,<20.0.2 || >20.0.2,<20.0.3 || >20.0.3,<20.0.4 || >20.0.4,<20.0.5 || >20.0.5,<20.0.6 || >20.0.6,<20.0.7 || >20.0.7"
 
 [package.extras]
-dev = ["py-make (>=0.1.0)", "twine", "wheel"]
-notebook = ["ipywidgets (>=6)"]
-telegram = ["requests"]
+docs = ["pygments-github-lexers (>=0.0.5)", "sphinx (>=2.0.0)", "sphinxcontrib-autoprogram (>=0.1.5)", "towncrier (>=18.5.0)"]
+testing = ["flaky (>=3.4.0)", "freezegun (>=0.3.11)", "pytest (>=4.0.0)", "pytest-cov (>=2.5.1)", "pytest-mock (>=1.10.0)", "pytest-randomly (>=1.0.0)", "psutil (>=5.6.1)", "pathlib2 (>=2.3.3)"]
 
 [[package]]
-name = "twine"
-version = "3.4.2"
-description = "Collection of utilities for publishing packages on PyPI"
+name = "tox-poetry-installer"
+version = "0.8.3"
+description = "A plugin for Tox that lets you install test environment dependencies from the Poetry lockfile"
 category = "dev"
 optional = false
-python-versions = ">=3.6"
+python-versions = ">=3.6.1,<4.0.0"
 
 [package.dependencies]
-colorama = ">=0.4.3"
-importlib-metadata = ">=3.6"
-keyring = ">=15.1"
-pkginfo = ">=1.4.2"
-readme-renderer = ">=21.0"
-requests = ">=2.20"
-requests-toolbelt = ">=0.8.0,<0.9.0 || >0.9.0"
-rfc3986 = ">=1.4.0"
-tqdm = ">=4.14"
+poetry = {version = ">=1.0.0,<2.0.0", optional = true, markers = "extra == \"poetry\""}
+poetry-core = ">=1.0.0,<2.0.0"
+tox = ">=3.8.0,<4.0.0"
+
+[package.extras]
+poetry = ["poetry (>=1.0.0,<2.0.0)"]
 
 [[package]]
 name = "typed-ast"
@@ -892,7 +1060,7 @@ python-versions = "*"
 name = "typing-extensions"
 version = "3.10.0.2"
 description = "Backported and Experimental Type Hints for Python 3.5+"
-category = "main"
+category = "dev"
 optional = false
 python-versions = "*"
 
@@ -909,6 +1077,25 @@ brotli = ["brotlipy (>=0.6.0)"]
 secure = ["pyOpenSSL (>=0.14)", "cryptography (>=1.3.4)", "idna (>=2.0.0)", "certifi", "ipaddress"]
 socks = ["PySocks (>=1.5.6,!=1.5.7,<2.0)"]
 
+[[package]]
+name = "virtualenv"
+version = "20.13.0"
+description = "Virtual Python Environment builder"
+category = "dev"
+optional = false
+python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,>=2.7"
+
+[package.dependencies]
+distlib = ">=0.3.1,<1"
+filelock = ">=3.2,<4"
+importlib-metadata = {version = ">=0.12", markers = "python_version < \"3.8\""}
+platformdirs = ">=2,<3"
+six = ">=1.9.0,<2"
+
+[package.extras]
+docs = ["proselint (>=0.10.2)", "sphinx (>=3)", "sphinx-argparse (>=0.2.5)", "sphinx-rtd-theme (>=0.4.3)", "towncrier (>=21.3)"]
+testing = ["coverage (>=4)", "coverage-enable-subprocess (>=1)", "flaky (>=3)", "pytest (>=4)", "pytest-env (>=0.6.2)", "pytest-freezegun (>=0.4.1)", "pytest-mock (>=2)", "pytest-randomly (>=1)", "pytest-timeout (>=1)", "packaging (>=20.0)"]
+
 [[package]]
 name = "webencodings"
 version = "0.5.1"
@@ -931,7 +1118,6 @@ testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytes
 
 [extras]
 coverage = []
-deploy = []
 docs = []
 format = []
 lint = []
@@ -940,7 +1126,7 @@ test = []
 [metadata]
 lock-version = "1.1"
 python-versions = "^3.7"
-content-hash = "68393ebe3eefa642fa0e8aba2087602539f17fc193df3f3faba9cce6b12d5998"
+content-hash = "37cd5845ee3010348472d35eabf63e6711fbd6662b9f0a640a91d8f801a3f817"
 
 [metadata.files]
 aafigure = [
@@ -971,9 +1157,13 @@ black = [
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+]
+tox-poetry-installer = [
+    {file = "tox-poetry-installer-0.8.3.tar.gz", hash = "sha256:04b6c7d368b67ef3cc4409e275b26eef3564a6487259bd9cc671587f5aaf4b4f"},
+    {file = "tox_poetry_installer-0.8.3-py3-none-any.whl", hash = "sha256:4cefad997ef5b8533811ceb5308b5cb6e6d6997af377c0b7d03b2dd43179c235"},
 ]
 typed-ast = [
     {file = "typed_ast-1.4.3-cp35-cp35m-manylinux1_i686.whl", hash = "sha256:2068531575a125b87a41802130fa7e29f26c09a2833fea68d9a40cf33902eba6"},
@@ -1507,6 +1785,10 @@ urllib3 = [
     {file = "urllib3-1.26.7-py2.py3-none-any.whl", hash = "sha256:c4fdf4019605b6e5423637e01bc9fe4daef873709a7973e195ceba0a62bbc844"},
     {file = "urllib3-1.26.7.tar.gz", hash = "sha256:4987c65554f7a2dbf30c18fd48778ef124af6fab771a377103da0585e2336ece"},
 ]
+virtualenv = [
+    {file = "virtualenv-20.13.0-py2.py3-none-any.whl", hash = "sha256:339f16c4a86b44240ba7223d0f93a7887c3ca04b5f9c8129da7958447d079b09"},
+    {file = "virtualenv-20.13.0.tar.gz", hash = "sha256:d8458cf8d59d0ea495ad9b34c2599487f8a7772d796f9910858376d1600dd2dd"},
+]
 webencodings = [
     {file = "webencodings-0.5.1-py2.py3-none-any.whl", hash = "sha256:a0af1213f3c2226497a97e2b3aa01a7e4bee4f403f95be16fc9acd2947514a78"},
     {file = "webencodings-0.5.1.tar.gz", hash = "sha256:b36a1c245f2d304965eb4e0a82848379241dc04b865afcc4aab16748587e1923"},
diff --git a/pyproject.toml b/pyproject.toml
index 4e9f11dfabf..d9d80d56be1 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -32,6 +32,7 @@ packages = [
 include = [
     { path = "CHANGES", format = "sdist" },
     { path = ".tmuxp.yaml", format = "sdist" },
+    { path = ".tmuxp-before-script.sh", format = "sdist" },
     { path = "tests", format = "sdist" },
     { path = "examples", format = "sdist" },
     { path = "docs", format = "sdist" },
@@ -50,7 +51,7 @@ tmuxp = 'tmuxp:cli.cli'
 python = "^3.7"
 click = ">7,<8.1"
 kaptan = ">=0.5.10"
-libtmux = "~0.10.2"
+libtmux = "~0.10.3"
 colorama = ">=0.3.9"
 
 [tool.poetry.dev-dependencies]
@@ -68,6 +69,8 @@ pytest = "*"
 pytest-rerunfailures = "*"
 pytest-mock = "*"
 pytest-cov = "*"
+tox = {version = "^3.24.5", extras = ["test"]}
+tox-poetry-installer = {extras = ["poetry"], version = "^0.8.3"}
 
 ### Coverage ###
 codecov = "*"
@@ -80,13 +83,13 @@ isort = "*"
 ### Lint ###
 flake8 = "*"
 
-### Deploy ###
-twine = "*"
-
 [tool.poetry.extras]
 docs = ["sphinx", "myst_parser", "sphinx-issues", "alagitpull", "sphinx-autodoc-typehints", "aafigure", "pillow"]
-test = ["pytest", "pytest-rerunfailures", "pytest-mock"]
+test = ["pytest", "pytest-rerunfailures", "pytest-mock", "tox", "tox-poetry-installer"]
 coverage = ["codecov", "coverage", "pytest-cov"]
 format = ["black", "isort"]
 lint = ["flake8"]
-deploy = ["twine"]
+
+[build-system]
+requires = ["poetry_core>=1.0.0"]
+build-backend = "poetry.core.masonry.api"
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 5ce56232fe4..00000000000
--- a/setup.py
+++ /dev/null
@@ -1,64 +0,0 @@
-"""tmuxp lives at <https://github.com/tmux-python/tmuxp>."""
-import sys
-
-from setuptools import setup
-
-about = {}
-with open("tmuxp/__about__.py") as fp:
-    exec(fp.read(), about)
-
-with open('requirements/base.txt') as f:
-    install_reqs = [line for line in f.read().split('\n') if line]
-
-with open('requirements/test.txt') as f:
-    tests_reqs = [line for line in f.read().split('\n') if line]
-
-if sys.version_info[0] > 2:
-    readme = open('README.md', encoding='utf-8').read()
-else:
-    readme = open('README.md').read()
-
-history = open('CHANGES').read().replace('.. :changelog:', '')
-
-
-setup(
-    name=about['__title__'],
-    version=about['__version__'],
-    url=about['__github__'],
-    project_urls={
-        'Changes': about['__changes__'],
-        'Documentation': about['__docs__'],
-        'Code': about['__github__'],
-        'Issue tracker': about['__tracker__'],
-    },
-    download_url=about['__pypi__'],
-    license=about['__license__'],
-    author=about['__author__'],
-    author_email=about['__email__'],
-    description=about['__description__'],
-    long_description=readme,
-    long_description_content_type="text/markdown",
-    packages=['tmuxp'],
-    include_package_data=True,
-    install_requires=install_reqs,
-    tests_require=tests_reqs,
-    zip_safe=False,
-    keywords=about['__title__'],
-    entry_points=dict(console_scripts=['tmuxp=tmuxp:cli.cli']),
-    classifiers=[
-        "Development Status :: 5 - Production/Stable",
-        "License :: OSI Approved :: MIT License",
-        "Operating System :: POSIX",
-        "Operating System :: MacOS :: MacOS X",
-        "Environment :: Web Environment",
-        "Intended Audience :: Developers",
-        "Programming Language :: Python",
-        "Programming Language :: Python :: 3.7",
-        "Programming Language :: Python :: 3.8",
-        "Programming Language :: Python :: 3.9",
-        "Programming Language :: Python :: 3.10",
-        "Programming Language :: Python :: Implementation :: PyPy",
-        "Topic :: Utilities",
-        "Topic :: System :: Shells",
-    ],
-)
diff --git a/tox.ini b/tox.ini
index cf419f32503..fde499fb2e2 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,21 @@
 [tox]
-envlist = py27, py33, py34, py35, py36
+isolated_build = True
+envlist = py37, py38, py39, py310
+skip_missing_interpreters = true
 
 [testenv]
-commands = make test []
+extras = 
+        test
+	docs
+allowlist_externals =
+        make
+	poetry
+require_poetry = true
+install_dev_deps = true
+locked_deps = 
+        pytest
+        pytest-cov
+commands = 
+        make test test='{posargs}'
+setenv = 
+        PYTHONPATH = {toxinidir}