diff --git a/CHANGELOG.md b/CHANGELOG.md
index 13c37104d86a..b06102bc1006 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -29,6 +29,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Disallow multiple selectors in arbitrary variants ([#10655](https://github.com/tailwindlabs/tailwindcss/pull/10655))
 - Sort class lists deterministically for Prettier plugin ([#10672](https://github.com/tailwindlabs/tailwindcss/pull/10672))
 - Ensure CLI builds have a non-zero exit code on failure ([#10703](https://github.com/tailwindlabs/tailwindcss/pull/10703))
+- Remove blocklisted classes from autocomplete ([#10844](https://github.com/tailwindlabs/tailwindcss/pull/10844))
 
 ### Changed
 
diff --git a/src/lib/setupContextUtils.js b/src/lib/setupContextUtils.js
index 0749da68dbdc..e17ba43c1096 100644
--- a/src/lib/setupContextUtils.js
+++ b/src/lib/setupContextUtils.js
@@ -1007,6 +1007,11 @@ function registerPlugins(plugins, context) {
       }
     }
 
+    // Exclude utilities that are known non-classes (e.g. from the blocklist)
+    if (context.notClassCache.size > 0) {
+      output = output.filter((cls) => !context.notClassCache.has(cls))
+    }
+
     return output
   }
 
diff --git a/tests/getClassList.test.js b/tests/getClassList.test.js
index 671a767ecfe5..06e8dd345538 100644
--- a/tests/getClassList.test.js
+++ b/tests/getClassList.test.js
@@ -191,6 +191,18 @@ crosscheck(() => {
     expect(classes).not.toContain('bg-red-500/50')
   })
 
+  it('should not generate utilities that are present in the blocklist', () => {
+    let config = {
+      blocklist: ['font-bold'],
+    }
+
+    let context = createContext(resolveConfig(config))
+    let classes = context.getClassList()
+
+    expect(classes).toContain('font-normal')
+    expect(classes).not.toContain('font-bold')
+  })
+
   it('should not generate utilities that are set to undefined or null to so that they are removed', () => {
     let config = {
       theme: {