diff --git a/packages/clients/src/helpers/is-response.ts b/packages/clients/src/helpers/is-response.ts
new file mode 100644
index 000000000..abdeed273
--- /dev/null
+++ b/packages/clients/src/helpers/is-response.ts
@@ -0,0 +1,19 @@
+/**
+ * Validates an object is of type Response without using `instanceof`.
+ *
+ * @remarks Check issue #509 for more context.
+ *
+ * @internal
+ */
+export const isResponse = (obj: unknown): obj is Response =>
+  obj !== null &&
+  obj !== undefined &&
+  typeof obj === 'object' &&
+  'status' in obj &&
+  typeof obj.status === 'number' &&
+  'statusText' in obj &&
+  typeof obj.statusText === 'string' &&
+  'headers' in obj &&
+  typeof obj.headers === 'object' &&
+  'body' in obj &&
+  typeof obj.body !== 'undefined'
diff --git a/packages/clients/src/scw/fetch/response-parser.ts b/packages/clients/src/scw/fetch/response-parser.ts
index 80535f565..bdcbeedc9 100644
--- a/packages/clients/src/scw/fetch/response-parser.ts
+++ b/packages/clients/src/scw/fetch/response-parser.ts
@@ -1,3 +1,4 @@
+import { isResponse } from '../../helpers/is-response'
 import { isJSONObject } from '../../helpers/json'
 import { parseScalewayError } from '../errors/error-parser'
 import { ScalewayError } from '../errors/scw-error'
@@ -50,7 +51,7 @@ export const responseParser =
     responseType: 'json' | 'text' | 'blob',
   ) =>
   async (response: Response): Promise<T> => {
-    if (!(response instanceof Response)) {
+    if (!isResponse(response)) {
       throw new TypeError('Invalid response object')
     }