diff --git a/Misc/NEWS.d/next/Build/2025-10-22-14-09-41.gh-issue-140421.2SCWXM.rst b/Misc/NEWS.d/next/Build/2025-10-22-14-09-41.gh-issue-140421.2SCWXM.rst
new file mode 100644
index 00000000000000..f3b207492a8093
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-10-22-14-09-41.gh-issue-140421.2SCWXM.rst
@@ -0,0 +1 @@
+Fix compilation errors in the perf trampoline on older macOS versions.
diff --git a/Python/perf_jit_trampoline.c b/Python/perf_jit_trampoline.c
index 8732be973616d4..e1a717202bbf7a 100644
--- a/Python/perf_jit_trampoline.c
+++ b/Python/perf_jit_trampoline.c
@@ -80,6 +80,17 @@
 #  include <sys/syscall.h>        // System call interface
 #endif
 
+#if defined(__APPLE__)
+#include <AvailabilityMacros.h>
+#if defined(MAC_OS_X_VERSION_MIN_REQUIRED) \
+        && (!defined(MAC_OS_X_VERSION_10_12) || \
+        MAC_OS_X_VERSION_MIN_REQUIRED < MAC_OS_X_VERSION_10_12)
+#define PY_PERF_JIT_USE_MACH_TIME
+#include <inttypes.h>
+#include <mach/mach_time.h>       // mach_absolute_time
+#endif
+#endif
+
 // =============================================================================
 //                           CONSTANTS AND CONFIGURATION
 // =============================================================================
@@ -284,6 +295,12 @@ static const intptr_t nanoseconds_per_second = 1000000000;
  * Returns: Current monotonic time in nanoseconds since an arbitrary epoch
  */
 static int64_t get_current_monotonic_ticks(void) {
+#if defined(__APPLE__) && defined(PY_PERF_JIT_USE_MACH_TIME)
+    /* clock_gettime() is not available before macOS 10.12.
+     * mach_absolute_time() should always return a value in
+     * nanoseconds on x86. */
+    return (int64_t)mach_absolute_time();
+#else
     struct timespec ts;
     if (clock_gettime(CLOCK_MONOTONIC, &ts) != 0) {
         Py_UNREACHABLE();  // Should never fail on supported systems
@@ -295,6 +312,7 @@ static int64_t get_current_monotonic_ticks(void) {
     result *= nanoseconds_per_second;
     result += ts.tv_nsec;
     return result;
+#endif
 }
 
 /*
diff --git a/Python/perf_trampoline.c b/Python/perf_trampoline.c
index 987e8d2a11a659..589049c735498a 100644
--- a/Python/perf_trampoline.c
+++ b/Python/perf_trampoline.c
@@ -145,6 +145,9 @@ any DWARF information available for them).
 #include <unistd.h>               // sysconf()
 #include <sys/time.h>           // gettimeofday()
 
+#if !defined(MAP_ANONYMOUS) && defined(MAP_ANON)
+#  define MAP_ANONYMOUS MAP_ANON
+#endif
 
 #if defined(__arm__) || defined(__arm64__) || defined(__aarch64__)
 #define PY_HAVE_INVALIDATE_ICACHE
diff --git a/configure b/configure
index 95e231f406a9a3..659aa9a26c3130 100755
--- a/configure
+++ b/configure
@@ -13836,7 +13836,15 @@ case $PLATFORM_TRIPLET in #(
   aarch64-linux-gnu) :
     perf_trampoline=yes ;; #(
   darwin) :
-    perf_trampoline=yes ;; #(
+    case $host_cpu in #(
+  p*pc*) :
+    perf_trampoline=no ;; #(
+  *) :
+    perf_trampoline=yes
+                 ;; #(
+  *) :
+     ;;
+esac ;; #(
   *) :
     perf_trampoline=no
  ;;
diff --git a/configure.ac b/configure.ac
index 65c37579633754..18efb6a70ef60b 100644
--- a/configure.ac
+++ b/configure.ac
@@ -3704,7 +3704,10 @@ AC_MSG_CHECKING([perf trampoline])
 AS_CASE([$PLATFORM_TRIPLET],
   [x86_64-linux-gnu], [perf_trampoline=yes],
   [aarch64-linux-gnu], [perf_trampoline=yes],
-  [darwin], [perf_trampoline=yes],
+  [darwin], AS_CASE([$host_cpu],
+                [p*pc*], [perf_trampoline=no],
+                [*], [perf_trampoline=yes]
+                ),
   [perf_trampoline=no]
 )
 AC_MSG_RESULT([$perf_trampoline])