diff --git a/news/10270.removal.rst b/news/10270.removal.rst
new file mode 100644
index 00000000000..1a63672a836
--- /dev/null
+++ b/news/10270.removal.rst
@@ -0,0 +1,2 @@
+Suppress location mismatch warnings when pip is invoked from a Python source
+tree, so ``ensurepip`` does not emit warnings on CPython ``make install``.
diff --git a/src/pip/_internal/locations/__init__.py b/src/pip/_internal/locations/__init__.py
index 7d5491d20ad..dba182d7578 100644
--- a/src/pip/_internal/locations/__init__.py
+++ b/src/pip/_internal/locations/__init__.py
@@ -303,6 +303,18 @@ def get_scheme(
         if skip_msys2_mingw_bug:
             continue
 
+        # CPython's POSIX install script invokes pip (via ensurepip) against the
+        # interpreter located in the source tree, not the install site. This
+        # triggers special logic in sysconfig that's not present in distutils.
+        # https://github.com/python/cpython/blob/8c21941ddaf/Lib/sysconfig.py#L178-L194
+        skip_cpython_build = (
+            sysconfig.is_python_build(check_home=True)
+            and not WINDOWS
+            and k in ("headers", "include", "platinclude")
+        )
+        if skip_cpython_build:
+            continue
+
         warning_contexts.append((old_v, new_v, f"scheme.{k}"))
 
     if not warning_contexts: