diff --git a/.changeset/responsive-selectpanel.md b/.changeset/responsive-selectpanel.md
new file mode 100644
index 00000000000..85bed4b926a
--- /dev/null
+++ b/.changeset/responsive-selectpanel.md
@@ -0,0 +1,5 @@
+---
+"@primer/react": patch
+---
+
+SelectPanel: Make SelectPanel full screen on narrow devices with a Save button
diff --git a/.playwright/snapshots/components/SelectPanel.test.ts-snapshots/SelectPanel-Default-responsive-width-light-modern-action-list--true-linux.png b/.playwright/snapshots/components/SelectPanel.test.ts-snapshots/SelectPanel-Default-responsive-width-light-modern-action-list--true-linux.png
index 1b994c3baf1..95d51676103 100644
Binary files a/.playwright/snapshots/components/SelectPanel.test.ts-snapshots/SelectPanel-Default-responsive-width-light-modern-action-list--true-linux.png and b/.playwright/snapshots/components/SelectPanel.test.ts-snapshots/SelectPanel-Default-responsive-width-light-modern-action-list--true-linux.png differ
diff --git a/packages/react/src/SelectPanel/SelectPanel.docs.json b/packages/react/src/SelectPanel/SelectPanel.docs.json
index 1a3677f2a6c..d28e8c92ea5 100644
--- a/packages/react/src/SelectPanel/SelectPanel.docs.json
+++ b/packages/react/src/SelectPanel/SelectPanel.docs.json
@@ -127,6 +127,12 @@
       "description": "Callback when the search input changes",
       "defaultValue": ""
     },
+    {
+      "name": "onCancel",
+      "type": "() => void",
+      "description": "(Narrow screens) Callback when the user hits cancel or close",
+      "defaultValue": ""
+    },
     {
       "name": "overlayProps",
       "type": "Partial<OverlayProps>",
diff --git a/packages/react/src/SelectPanel/SelectPanel.features.stories.tsx b/packages/react/src/SelectPanel/SelectPanel.features.stories.tsx
index 1c8e5719a6a..d1dfc3751ce 100644
--- a/packages/react/src/SelectPanel/SelectPanel.features.stories.tsx
+++ b/packages/react/src/SelectPanel/SelectPanel.features.stories.tsx
@@ -171,6 +171,7 @@ export const SingleSelect = () => {
         selected={selected}
         onSelectedChange={setSelected}
         onFilterChange={setFilter}
+        onCancel={() => setOpen(false)}
         width="medium"
       />
     </FormControl>
@@ -560,3 +561,54 @@ export const AsyncFetch: StoryObj<SelectPanelProps> = {
     },
   },
 }
+
+export const WithOnCancel = () => {
+  const [intialSelection, setInitialSelection] = React.useState<ItemInput[]>(items.slice(1, 3))
+
+  const [selected, setSelected] = React.useState<ItemInput[]>(intialSelection)
+  const [filter, setFilter] = React.useState('')
+  const filteredItems = items.filter(
+    item =>
+      // design guidelines say to always show selected items in the list
+      selected.some(selectedItem => selectedItem.text === item.text) ||
+      // then filter the rest
+      item.text.toLowerCase().startsWith(filter.toLowerCase()),
+  )
+  // design guidelines say to sort selected items first
+  const selectedItemsSortedFirst = filteredItems.sort((a, b) => {
+    const aIsSelected = selected.some(selectedItem => selectedItem.text === a.text)
+    const bIsSelected = selected.some(selectedItem => selectedItem.text === b.text)
+    if (aIsSelected && !bIsSelected) return -1
+    if (!aIsSelected && bIsSelected) return 1
+    return 0
+  })
+
+  const [open, setOpen] = useState(false)
+  React.useEffect(() => {
+    if (!open) setInitialSelection(selected) // set initialSelection for next time
+  }, [open, selected])
+
+  return (
+    <FormControl>
+      <FormControl.Label>Labels</FormControl.Label>
+      <SelectPanel
+        title="Select labels"
+        placeholder="Select labels"
+        subtitle="Use labels to organize issues and pull requests"
+        renderAnchor={({children, ...anchorProps}) => (
+          <Button trailingAction={TriangleDownIcon} {...anchorProps} aria-haspopup="dialog">
+            {children}
+          </Button>
+        )}
+        open={open}
+        onOpenChange={setOpen}
+        items={selectedItemsSortedFirst}
+        selected={selected}
+        onSelectedChange={setSelected}
+        onCancel={() => setSelected(intialSelection)}
+        onFilterChange={setFilter}
+        width="medium"
+      />
+    </FormControl>
+  )
+}
diff --git a/packages/react/src/SelectPanel/SelectPanel.module.css b/packages/react/src/SelectPanel/SelectPanel.module.css
index e607edba2a1..fef33c5de77 100644
--- a/packages/react/src/SelectPanel/SelectPanel.module.css
+++ b/packages/react/src/SelectPanel/SelectPanel.module.css
@@ -5,17 +5,22 @@
   flex-direction: column;
 }
 
-.Content {
+.Header {
+  display: flex;
+  justify-content: space-between;
+  align-items: center;
   padding-top: var(--base-size-8);
-  padding-right: var(--base-size-16);
-  padding-left: var(--base-size-16);
+  padding-right: var(--base-size-8);
+  padding-left: var(--base-size-8);
 }
 
 .Title {
+  margin-left: var(--base-size-8);
   font-size: var(--text-body-size-medium);
 }
 
 .Subtitle {
+  margin-left: var(--base-size-8);
   font-size: var(--text-body-size-small);
   color: var(--fgColor-muted);
 }
@@ -31,3 +36,22 @@
   height: inherit;
   max-height: inherit;
 }
+
+.ResponsiveCloseButton {
+  display: none;
+
+  @media screen and (--viewportRange-narrow) {
+    display: inline-grid;
+  }
+}
+
+.ResponsiveFooter {
+  display: none;
+  padding: var(--base-size-16);
+
+  @media screen and (--viewportRange-narrow) {
+    display: flex;
+    gap: var(--stack-gap-condensed);
+    justify-content: right;
+  }
+}
diff --git a/packages/react/src/SelectPanel/SelectPanel.tsx b/packages/react/src/SelectPanel/SelectPanel.tsx
index 396bb717309..bc729f2c7ae 100644
--- a/packages/react/src/SelectPanel/SelectPanel.tsx
+++ b/packages/react/src/SelectPanel/SelectPanel.tsx
@@ -1,4 +1,4 @@
-import {SearchIcon, TriangleDownIcon} from '@primer/octicons-react'
+import {SearchIcon, TriangleDownIcon, XIcon} from '@primer/octicons-react'
 import React, {useCallback, useEffect, useMemo, useRef, useState} from 'react'
 import type {AnchoredOverlayProps} from '../AnchoredOverlay'
 import {AnchoredOverlay} from '../AnchoredOverlay'
@@ -11,7 +11,7 @@ import type {OverlayProps} from '../Overlay'
 import type {TextInputProps} from '../TextInput'
 import type {ItemProps, ItemInput} from './types'
 
-import {Button} from '../Button'
+import {Button, IconButton} from '../Button'
 import {useProvidedRefOrCreate} from '../hooks'
 import type {FocusZoneHookSettings} from '../hooks/useFocusZone'
 import {useId} from '../hooks/useId'
@@ -22,7 +22,6 @@ import type {FilteredActionListLoadingType} from '../FilteredActionList/Filtered
 import {FilteredActionListLoadingTypes} from '../FilteredActionList/FilteredActionListLoaders'
 import {useFeatureFlag} from '../FeatureFlags'
 import {announce} from '@primer/live-region-element'
-
 import classes from './SelectPanel.module.css'
 import {clsx} from 'clsx'
 
@@ -128,6 +127,7 @@ interface SelectPanelBaseProps {
   footer?: string | React.ReactElement
   initialLoadingType?: InitialLoadingType
   className?: string
+  onCancel?: () => void
 }
 
 export type SelectPanelProps = SelectPanelBaseProps &
@@ -189,6 +189,7 @@ export function SelectPanel({
   height,
   width,
   id,
+  onCancel,
   ...listProps
 }: SelectPanelProps): JSX.Element {
   const titleId = useId()
@@ -352,7 +353,7 @@ export function SelectPanel({
     [onOpenChange],
   )
   const onClose = useCallback(
-    (gesture: Parameters<Exclude<AnchoredOverlayProps['onClose'], undefined>>[0] | 'selection') => {
+    (gesture: Parameters<Exclude<AnchoredOverlayProps['onClose'], undefined>>[0] | 'selection' | 'escape') => {
       onOpenChange(false, gesture)
     },
     [onOpenChange],
@@ -454,6 +455,7 @@ export function SelectPanel({
         height={height}
         width={width}
         anchorId={id}
+        variant={{regular: 'anchored', narrow: 'fullscreen'}}
         pinPosition={!height}
       >
         <LiveRegionOutlet />
@@ -472,24 +474,54 @@ export function SelectPanel({
           sx={enabled ? undefined : {display: 'flex', flexDirection: 'column', height: 'inherit', maxHeight: 'inherit'}}
           className={enabled ? classes.Wrapper : undefined}
         >
-          <Box sx={enabled ? undefined : {pt: 2, px: 3}} className={enabled ? classes.Content : undefined}>
-            <Heading
-              as="h1"
-              id={titleId}
-              sx={enabled ? undefined : {fontSize: 1}}
-              className={enabled ? classes.Title : undefined}
-            >
-              {title}
-            </Heading>
-            {subtitle ? (
-              <Box
-                id={subtitleId}
-                sx={enabled ? undefined : {fontSize: 0, color: 'fg.muted'}}
-                className={enabled ? classes.Subtitle : undefined}
+          <Box
+            sx={
+              enabled
+                ? undefined
+                : {
+                    display: 'flex',
+                    justifyContent: 'space-between',
+                    alignItems: 'center',
+                    paddingTop: 2,
+                    paddingRight: 2,
+                    paddingLeft: 2,
+                  }
+            }
+            className={enabled ? classes.Header : undefined}
+          >
+            <div>
+              <Heading
+                as="h1"
+                id={titleId}
+                sx={enabled ? undefined : {fontSize: 1, marginLeft: 2}}
+                className={enabled ? classes.Title : undefined}
               >
-                {subtitle}
-              </Box>
-            ) : null}
+                {title}
+              </Heading>
+              {subtitle ? (
+                <Box
+                  id={subtitleId}
+                  sx={enabled ? undefined : {marginLeft: 2, fontSize: 0, color: 'fg.muted'}}
+                  className={enabled ? classes.Subtitle : undefined}
+                >
+                  {subtitle}
+                </Box>
+              ) : null}
+            </div>
+            {onCancel && (
+              <IconButton
+                type="button"
+                variant="invisible"
+                icon={XIcon}
+                aria-label="Cancel and close"
+                sx={enabled ? undefined : {display: ['inline-grid', 'inline-grid', 'none', 'none']}}
+                className={enabled ? classes.ResponsiveCloseButton : undefined}
+                onClick={() => {
+                  onCancel()
+                  onClose('escape')
+                }}
+              />
+            )}
           </Box>
           <FilteredActionList
             filterValue={filterValue}
@@ -514,7 +546,7 @@ export function SelectPanel({
             className={enabled ? clsx(className, classes.FilteredActionList) : className}
             announcementsEnabled={false}
           />
-          {footer && (
+          {footer ? (
             <Box
               sx={
                 enabled
@@ -530,7 +562,31 @@ export function SelectPanel({
             >
               {footer}
             </Box>
-          )}
+          ) : isMultiSelectVariant(selected) ? (
+            /* Save and Cancel buttons are only useful for multiple selection, single selection instantly closes the panel */
+            <div className={clsx(classes.Footer, classes.ResponsiveFooter)}>
+              {/* we add a save and cancel button on narrow screens when SelectPanel is full-screen */}
+              {onCancel && (
+                <Button
+                  size="medium"
+                  onClick={() => {
+                    onCancel()
+                    onClose('escape')
+                  }}
+                >
+                  Cancel
+                </Button>
+              )}
+              <Button
+                variant="primary"
+                size="medium"
+                block={onCancel ? false : true}
+                onClick={() => onClose('click-outside')}
+              >
+                Save
+              </Button>
+            </div>
+          ) : null}
         </Box>
       </AnchoredOverlay>
     </LiveRegion>