diff --git a/packages/react/src/Button/ButtonBase.tsx b/packages/react/src/Button/ButtonBase.tsx
index 6303ffc5e5c..bc2c02db9cf 100644
--- a/packages/react/src/Button/ButtonBase.tsx
+++ b/packages/react/src/Button/ButtonBase.tsx
@@ -196,11 +196,11 @@ const ButtonBase = forwardRef(
               </>
             )}
           </Box>
-          {loading && (
+          {loading ? (
             <VisuallyHidden>
               <AriaStatus id={loadingAnnouncementID}>{loadingAnnouncement}</AriaStatus>
             </VisuallyHidden>
-          )}
+          ) : null}
         </ConditionalWrapper>
       )
     }
@@ -228,7 +228,7 @@ const ButtonBase = forwardRef(
           data-variant={variant}
           data-label-wrap={labelWrap}
           data-has-count={count !== undefined ? true : undefined}
-          aria-describedby={[loadingAnnouncementID, ariaDescribedBy]
+          aria-describedby={[loading && loadingAnnouncementID, ariaDescribedBy]
             .filter(descriptionID => Boolean(descriptionID))
             .join(' ')}
           // aria-labelledby is needed because the accessible name becomes unset when the button is in a loading state.
diff --git a/packages/react/src/Button/IconButton.features.stories.tsx b/packages/react/src/Button/IconButton.features.stories.tsx
index 75050d7c805..8175025b5b4 100644
--- a/packages/react/src/Button/IconButton.features.stories.tsx
+++ b/packages/react/src/Button/IconButton.features.stories.tsx
@@ -91,7 +91,10 @@ export const KeybindingHintOnDescription = () => (
     aria-label="Notifications"
     description="You have unread notifications"
     keybindingHint="G+N"
+    keybindingDescription="G, N"
   />
 )
 
-export const KeybindingHint = () => <IconButton icon={BoldIcon} aria-label="Bold" keybindingHint="Mod+B" />
+export const KeybindingHint = () => (
+  <IconButton icon={BoldIcon} aria-label="Bold" keybindingHint="Mod+B" keybindingDescription="Command, B" />
+)
diff --git a/packages/react/src/Button/IconButton.tsx b/packages/react/src/Button/IconButton.tsx
index 4b86ea1bd48..dbdbf86eb54 100644
--- a/packages/react/src/Button/IconButton.tsx
+++ b/packages/react/src/Button/IconButton.tsx
@@ -22,6 +22,7 @@ const IconButton = forwardRef(
       unsafeDisableTooltip = false,
       keyshortcuts,
       keybindingHint,
+      keybindingDescription,
       className,
       ...props
     },
@@ -67,6 +68,7 @@ const IconButton = forwardRef(
           type={description ? undefined : 'label'}
           direction={tooltipDirection}
           keybindingHint={keybindingHint ?? keyshortcuts}
+          keybindingDescription={keybindingDescription}
         >
           <ButtonBase
             icon={Icon}
diff --git a/packages/react/src/Button/types.ts b/packages/react/src/Button/types.ts
index 6824ae17e69..379557aa7f9 100644
--- a/packages/react/src/Button/types.ts
+++ b/packages/react/src/Button/types.ts
@@ -97,6 +97,7 @@ export type IconButtonProps = ButtonA11yProps & {
   /** @deprecated Use `keybindingHint` instead. */
   keyshortcuts?: string
   keybindingHint?: string
+  keybindingDescription?: string
 } & Omit<ButtonBaseProps, 'aria-label' | 'aria-labelledby'>
 
 // adopted from React.AnchorHTMLAttributes
diff --git a/packages/react/src/KeybindingHint/props.ts b/packages/react/src/KeybindingHint/props.ts
index 7df8f7ebd21..f3ca3003975 100644
--- a/packages/react/src/KeybindingHint/props.ts
+++ b/packages/react/src/KeybindingHint/props.ts
@@ -3,6 +3,8 @@ export type KeybindingHintFormat = 'condensed' | 'full'
 export type KeybindingHintVariant = 'normal' | 'onEmphasis' | 'onPrimary'
 
 export interface KeybindingHintProps {
+  description?: string
+
   /**
    * The keys involved in this keybinding. These should be the full names of the keys as would
    * be returned by `KeyboardEvent.key` (e.g. "Control", "Shift", "ArrowUp", "a", etc.).
diff --git a/packages/react/src/TooltipV2/Tooltip.tsx b/packages/react/src/TooltipV2/Tooltip.tsx
index 2949dc434d5..28cbb8f91e6 100644
--- a/packages/react/src/TooltipV2/Tooltip.tsx
+++ b/packages/react/src/TooltipV2/Tooltip.tsx
@@ -142,6 +142,7 @@ export type TooltipProps = React.PropsWithChildren<
     text: string
     type?: 'label' | 'description'
     keybindingHint?: KeybindingHintProps['keys']
+    keybindingDescription?: KeybindingHintProps['description']
   } & SxProp
 > &
   React.HTMLAttributes<HTMLElement>
@@ -201,10 +202,21 @@ export const TooltipContext = React.createContext<{tooltipId?: string}>({})
 
 export const Tooltip = React.forwardRef(
   (
-    {direction = 's', text, type = 'description', children, id, className, keybindingHint, ...rest}: TooltipProps,
+    {
+      direction = 's',
+      text,
+      type = 'description',
+      children,
+      id,
+      className,
+      keybindingHint,
+      keybindingDescription,
+      ...rest
+    }: TooltipProps,
     forwardedRef,
   ) => {
     const tooltipId = useId(id)
+    const controlHintId = useId()
     const child = Children.only(children)
     const triggerRef = useProvidedRefOrCreate(forwardedRef as React.RefObject<HTMLElement>)
     const tooltipElRef = useRef<HTMLDivElement>(null)
@@ -355,7 +367,10 @@ export const Tooltip = React.forwardRef(
             React.cloneElement(child as React.ReactElement<TriggerPropsType>, {
               ref: triggerRef,
               // If it is a type description, we use tooltip to describe the trigger
-              'aria-describedby': type === 'description' ? tooltipId : child.props['aria-describedby'],
+              'aria-describedby':
+                type === 'description'
+                  ? [tooltipId, controlHintId].join(' ')
+                  : [child.props['aria-describedby'], controlHintId].filter(Boolean).join(' '),
               // If it is a label type, we use tooltip to label the trigger
               'aria-labelledby': type === 'label' ? tooltipId : child.props['aria-labelledby'],
               onBlur: (event: React.FocusEvent) => {
@@ -400,19 +415,21 @@ export const Tooltip = React.forwardRef(
             role={type === 'description' ? 'tooltip' : undefined}
             // stop AT from announcing the tooltip twice: when it is a label type it will be announced with "aria-labelledby",when it is a description type it will be announced with "aria-describedby"
             aria-hidden={true}
-            id={tooltipId}
             // mouse leave and enter on the tooltip itself is needed to keep the tooltip open when the mouse is over the tooltip
             onMouseEnter={openTooltip}
             onMouseLeave={closeTooltip}
           >
-            {text}
-            {keybindingHint && (
+            <span id={tooltipId}>{text}</span>
+            {keybindingHint ? (
               <span className={clsx(classes.keybindingHintContainer, text && classes.hasTextBefore)}>
                 <VisuallyHidden>(</VisuallyHidden>
                 <KeybindingHint keys={keybindingHint} format="condensed" variant="onEmphasis" size="small" />
                 <VisuallyHidden>)</VisuallyHidden>
               </span>
-            )}
+            ) : null}
+            {keybindingDescription ? (
+              <VisuallyHidden id={controlHintId}>. {keybindingDescription}</VisuallyHidden>
+            ) : null}
           </StyledTooltip>
         </>
       </TooltipContext.Provider>