diff --git a/pandas/tests/frame/test_arithmetic.py b/pandas/tests/frame/test_arithmetic.py
index e7b7f3e524d44..d9f251a1b5304 100644
--- a/pandas/tests/frame/test_arithmetic.py
+++ b/pandas/tests/frame/test_arithmetic.py
@@ -1536,3 +1536,18 @@ def test_dataframe_blockwise_slicelike():
 
         expected = pd.DataFrame({i: left[i] + right[i] for i in left.columns})
         tm.assert_frame_equal(res, expected)
+
+
+@pytest.mark.parametrize(
+    "df, col_dtype",
+    [
+        (pd.DataFrame([[1.0, 2.0], [4.0, 5.0]], columns=list("ab")), "float64"),
+        (pd.DataFrame([[1.0, "b"], [4.0, "b"]], columns=list("ab")), "object"),
+    ],
+)
+def test_dataframe_operation_with_non_numeric_types(df, col_dtype):
+    # GH #22663
+    expected = pd.DataFrame([[0.0, np.nan], [3.0, np.nan]], columns=list("ab"))
+    expected = expected.astype({"b": col_dtype})
+    result = df + pd.Series([-1.0], index=list("a"))
+    tm.assert_frame_equal(result, expected)