diff --git a/nats/src/nats/js/api.py b/nats/src/nats/js/api.py
index cdd254db..34738494 100644
--- a/nats/src/nats/js/api.py
+++ b/nats/src/nats/js/api.py
@@ -314,6 +314,9 @@ class StreamConfig(Base):
     deny_purge: bool = False
     allow_rollup_hdrs: bool = False
 
+    # Sequence from which the stream starts when created. Introduced in nats-server 2.10.0.
+    first_seq: Optional[int] = None
+
     # Allow republish of the message after being sequenced and stored.
     republish: Optional[RePublish] = None
     subject_transform: Optional[SubjectTransform] = None
diff --git a/nats/tests/test_js.py b/nats/tests/test_js.py
index 1b51edd5..ef6fc3c9 100644
--- a/nats/tests/test_js.py
+++ b/nats/tests/test_js.py
@@ -4902,6 +4902,49 @@ async def test_fetch_pull_subscribe_bind(self):
 
         await nc.close()
 
+    @async_test
+    async def test_stream_first_seq(self):
+        nc = await nats.connect()
+
+        js = nc.jetstream()
+
+        # Create a stream with first_seq set to 1000
+        await js.add_stream(
+            name="FIRSTSEQ",
+            subjects=["test"],
+            first_seq=1000,
+        )
+
+        # Publish some messages
+        ack1 = await js.publish("test", b"message 1")
+        assert ack1.seq == 1000
+
+        ack2 = await js.publish("test", b"message 2")
+        assert ack2.seq == 1001
+
+        ack3 = await js.publish("test", b"message 3")
+        assert ack3.seq == 1002
+
+        # Verify stream info shows the correct first_seq in state
+        sinfo = await js.stream_info("FIRSTSEQ")
+        assert sinfo.state.first_seq == 1000
+        assert sinfo.state.last_seq == 1002
+        assert sinfo.state.messages == 3
+
+        # Verify the config has first_seq set
+        assert sinfo.config.first_seq == 1000
+
+        # Test retrieving messages by sequence
+        msg = await js.get_msg("FIRSTSEQ", seq=1000)
+        assert msg.seq == 1000
+        assert msg.data == b"message 1"
+
+        msg = await js.get_msg("FIRSTSEQ", seq=1001)
+        assert msg.seq == 1001
+        assert msg.data == b"message 2"
+
+        await nc.close()
+
 
 class BadStreamNamesTest(SingleJetStreamServerTestCase):
     @async_test