diff --git a/clang/lib/Frontend/CompilerInvocation.cpp b/clang/lib/Frontend/CompilerInvocation.cpp
index 691f3b989b81e..7e17c3e49acaf 100644
--- a/clang/lib/Frontend/CompilerInvocation.cpp
+++ b/clang/lib/Frontend/CompilerInvocation.cpp
@@ -4012,6 +4012,7 @@ bool CompilerInvocation::ParseLangArgs(LangOptions &Opts, ArgList &Args,
 
       if (TT.getArch() == llvm::Triple::UnknownArch ||
           !(TT.getArch() == llvm::Triple::aarch64 || TT.isPPC() ||
+            TT.getArch() == llvm::Triple::systemz ||
             TT.getArch() == llvm::Triple::nvptx ||
             TT.getArch() == llvm::Triple::nvptx64 ||
             TT.getArch() == llvm::Triple::amdgcn ||
diff --git a/clang/tools/clang-linker-wrapper/ClangLinkerWrapper.cpp b/clang/tools/clang-linker-wrapper/ClangLinkerWrapper.cpp
index 576e8f2cd7f8f..b3efa56b33021 100644
--- a/clang/tools/clang-linker-wrapper/ClangLinkerWrapper.cpp
+++ b/clang/tools/clang-linker-wrapper/ClangLinkerWrapper.cpp
@@ -552,6 +552,7 @@ Expected<StringRef> linkDevice(ArrayRef<StringRef> InputFiles,
   case Triple::aarch64_be:
   case Triple::ppc64:
   case Triple::ppc64le:
+  case Triple::systemz:
     return generic::clang(InputFiles, Args);
   default:
     return createStringError(inconvertibleErrorCode(),
diff --git a/llvm/lib/Frontend/OpenMP/OMPContext.cpp b/llvm/lib/Frontend/OpenMP/OMPContext.cpp
index e870c5aa2ba6b..37936d6000c89 100644
--- a/llvm/lib/Frontend/OpenMP/OMPContext.cpp
+++ b/llvm/lib/Frontend/OpenMP/OMPContext.cpp
@@ -44,6 +44,7 @@ OMPContext::OMPContext(bool IsDeviceCompilation, Triple TargetTriple) {
   case Triple::ppcle:
   case Triple::ppc64:
   case Triple::ppc64le:
+  case Triple::systemz:
   case Triple::x86:
   case Triple::x86_64:
     ActiveTraits.set(unsigned(TraitProperty::device_kind_cpu));
diff --git a/openmp/libomptarget/CMakeLists.txt b/openmp/libomptarget/CMakeLists.txt
index a74eff0c0bebf..b382137b70ee2 100644
--- a/openmp/libomptarget/CMakeLists.txt
+++ b/openmp/libomptarget/CMakeLists.txt
@@ -56,6 +56,8 @@ set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} x86_64-pc-linux-gnu-L
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda-JIT-LTO")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} s390x-ibm-linux-gnu")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} s390x-ibm-linux-gnu-LTO")
 
 # Once the plugins for the different targets are validated, they will be added to
 # the list of supported targets in the current system.
diff --git a/openmp/libomptarget/plugins-nextgen/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/CMakeLists.txt
index 3ca02368253ef..b6fc136e8a179 100644
--- a/openmp/libomptarget/plugins-nextgen/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/CMakeLists.txt
@@ -12,12 +12,15 @@
 
 add_subdirectory(common)
 
-# void build_generic_elf64(string tmachine, string tmachine_name, string tmachine_libname, string elf_machine_id);
+# void build_generic_elf64(string tmachine, string tmachine_name, string tmachine_libname,
+#                          string tmachine_llvm, string tmachine_triple, string elf_machine_id);
 # - build a plugin for an ELF based generic 64-bit target based on libffi.
 # - tmachine: name of the machine processor as used in the cmake build system.
 # - tmachine_name: name of the machine to be printed with the debug messages.
 # - tmachine_libname: machine name to be appended to the plugin library name.
-macro(build_generic_elf64 tmachine tmachine_name tmachine_libname tmachine_triple elf_machine_id)
+# - tmachine_llvm: LLVM triple for the processor
+# - tmachine_triple: GNU target triple
+macro(build_generic_elf64 tmachine tmachine_name tmachine_libname tmachine_llvm tmachine_triple elf_machine_id)
 if(CMAKE_SYSTEM_PROCESSOR MATCHES "${tmachine}$")
   # Define macro to be used as prefix of the runtime messages for this target.
   add_definitions("-DTARGET_NAME=${tmachine_name}")
@@ -30,7 +33,7 @@ if(CMAKE_SYSTEM_PROCESSOR MATCHES "${tmachine}$")
   add_definitions("-DTARGET_ELF_ID=${elf_machine_id}")
 
   # Define target triple
-  add_definitions("-DLIBOMPTARGET_NEXTGEN_GENERIC_PLUGIN_TRIPLE=${tmachine}")
+  add_definitions("-DLIBOMPTARGET_NEXTGEN_GENERIC_PLUGIN_TRIPLE=${tmachine_llvm}")
 
   add_llvm_library("omptarget.rtl.${tmachine_libname}"
     SHARED
diff --git a/openmp/libomptarget/plugins-nextgen/aarch64/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/aarch64/CMakeLists.txt
index 2c2b753590e20..663ab4d60ff91 100644
--- a/openmp/libomptarget/plugins-nextgen/aarch64/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/aarch64/CMakeLists.txt
@@ -11,7 +11,7 @@
 ##===----------------------------------------------------------------------===##
 
 if(CMAKE_SYSTEM_NAME MATCHES "Linux")
-  build_generic_elf64("aarch64" "aarch64" "aarch64" "aarch64-unknown-linux-gnu" "183")
+  build_generic_elf64("aarch64" "aarch64" "aarch64" "aarch64" "aarch64-unknown-linux-gnu" "183")
 else()
  libomptarget_say("Not building aarch64 NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/openmp/libomptarget/plugins-nextgen/ppc64/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/ppc64/CMakeLists.txt
index 0cccc9cb82e42..77466c111ee0a 100644
--- a/openmp/libomptarget/plugins-nextgen/ppc64/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/ppc64/CMakeLists.txt
@@ -11,7 +11,7 @@
 ##===----------------------------------------------------------------------===##
 
 if(CMAKE_SYSTEM_NAME MATCHES "Linux")
-  build_generic_elf64("ppc64" "PPC64" "ppc64" "powerpc64-ibm-linux-gnu" "21")
+  build_generic_elf64("ppc64" "PPC64" "ppc64" "ppc64" "powerpc64-ibm-linux-gnu" "21")
 else()
  libomptarget_say("Not building ppc64 NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/openmp/libomptarget/plugins-nextgen/ppc64le/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/ppc64le/CMakeLists.txt
index 9461d79d145df..91d21627a3272 100644
--- a/openmp/libomptarget/plugins-nextgen/ppc64le/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/ppc64le/CMakeLists.txt
@@ -11,7 +11,7 @@
 ##===----------------------------------------------------------------------===##
 
 if(CMAKE_SYSTEM_NAME MATCHES "Linux")
-  build_generic_elf64("ppc64le" "PPC64le" "ppc64" "powerpc64le-ibm-linux-gnu" "21")
+  build_generic_elf64("ppc64le" "PPC64le" "ppc64" "ppc64le" "powerpc64le-ibm-linux-gnu" "21")
 else()
  libomptarget_say("Not building ppc64le NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/openmp/libomptarget/plugins-nextgen/s390x/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/s390x/CMakeLists.txt
index 1b12a29289998..0388a235d2899 100644
--- a/openmp/libomptarget/plugins-nextgen/s390x/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/s390x/CMakeLists.txt
@@ -11,7 +11,7 @@
 ##===----------------------------------------------------------------------===##
 
 if(CMAKE_SYSTEM_NAME MATCHES "Linux")
- build_generic_elf64("SystemZ" "S390X" "s390x" "s390x-ibm-linux-gnu" "22")
+ build_generic_elf64("s390x" "S390X" "s390x" "systemz" "s390x-ibm-linux-gnu" "22")
 else()
  libomptarget_say("Not building s390x NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/openmp/libomptarget/plugins-nextgen/x86_64/CMakeLists.txt b/openmp/libomptarget/plugins-nextgen/x86_64/CMakeLists.txt
index 129d526a2ae78..27cf3e069a377 100644
--- a/openmp/libomptarget/plugins-nextgen/x86_64/CMakeLists.txt
+++ b/openmp/libomptarget/plugins-nextgen/x86_64/CMakeLists.txt
@@ -11,7 +11,7 @@
 ##===----------------------------------------------------------------------===##
 
 if(CMAKE_SYSTEM_NAME MATCHES "Linux")
-  build_generic_elf64("x86_64" "x86_64" "x86_64" "x86_64-pc-linux-gnu" "62")
+  build_generic_elf64("x86_64" "x86_64" "x86_64" "x86_64" "x86_64-pc-linux-gnu" "62")
 else()
  libomptarget_say("Not building x86_64 NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/openmp/libomptarget/src/CMakeLists.txt b/openmp/libomptarget/src/CMakeLists.txt
index 9bc3f3339583d..d0971bd4ef079 100644
--- a/openmp/libomptarget/src/CMakeLists.txt
+++ b/openmp/libomptarget/src/CMakeLists.txt
@@ -73,6 +73,7 @@ if (NOT LIBOMPTARGET_PLUGINS_TO_LOAD)
 	check_plugin_target(cuda)
 	check_plugin_target(aarch64)
 	check_plugin_target(amdgpu)
+	check_plugin_target(s390x)
 endif()
 
 list(TRANSFORM LIBOMPTARGET_PLUGINS_TO_LOAD PREPEND "\"libomptarget.rtl.")
diff --git a/openmp/libomptarget/test/api/omp_dynamic_shared_memory.c b/openmp/libomptarget/test/api/omp_dynamic_shared_memory.c
index 5095a69a375c9..3fe75f24db3e6 100644
--- a/openmp/libomptarget/test/api/omp_dynamic_shared_memory.c
+++ b/openmp/libomptarget/test/api/omp_dynamic_shared_memory.c
@@ -10,6 +10,8 @@
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 // UNSUPPORTED: aarch64-unknown-linux-gnu
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <omp.h>
 #include <stdio.h>
diff --git a/openmp/libomptarget/test/jit/empty_kernel_lvl1.c b/openmp/libomptarget/test/jit/empty_kernel_lvl1.c
index c908c8ba06509..a0b8cd448837d 100644
--- a/openmp/libomptarget/test/jit/empty_kernel_lvl1.c
+++ b/openmp/libomptarget/test/jit/empty_kernel_lvl1.c
@@ -32,5 +32,7 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include "empty_kernel.inc"
diff --git a/openmp/libomptarget/test/jit/empty_kernel_lvl2.c b/openmp/libomptarget/test/jit/empty_kernel_lvl2.c
index 0b88d33292c57..81a04f55ce43d 100644
--- a/openmp/libomptarget/test/jit/empty_kernel_lvl2.c
+++ b/openmp/libomptarget/test/jit/empty_kernel_lvl2.c
@@ -92,5 +92,7 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include "empty_kernel.inc"
diff --git a/openmp/libomptarget/test/jit/type_punning.c b/openmp/libomptarget/test/jit/type_punning.c
index 23aa69bba7b95..10e3d2cef718b 100644
--- a/openmp/libomptarget/test/jit/type_punning.c
+++ b/openmp/libomptarget/test/jit/type_punning.c
@@ -12,6 +12,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 // Ensure that there is only the kernel function left, not any outlined
 // parallel regions.
diff --git a/openmp/libomptarget/test/mapping/auto_zero_copy.cpp b/openmp/libomptarget/test/mapping/auto_zero_copy.cpp
index 6f9d8c2b128c9..46641200bb56e 100644
--- a/openmp/libomptarget/test/mapping/auto_zero_copy.cpp
+++ b/openmp/libomptarget/test/mapping/auto_zero_copy.cpp
@@ -13,6 +13,8 @@
 // UNSUPPORTED: nvptx64-nvidia-cuda-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 // REQUIRES: unified_shared_memory
 
diff --git a/openmp/libomptarget/test/mapping/auto_zero_copy_globals.cpp b/openmp/libomptarget/test/mapping/auto_zero_copy_globals.cpp
index 4a13d270aeebe..55dfb2807ebc7 100644
--- a/openmp/libomptarget/test/mapping/auto_zero_copy_globals.cpp
+++ b/openmp/libomptarget/test/mapping/auto_zero_copy_globals.cpp
@@ -9,6 +9,8 @@
 // UNSUPPORTED: nvptx64-nvidia-cuda-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 // REQUIRES: unified_shared_memory
 
diff --git a/openmp/libomptarget/test/offloading/barrier_fence.c b/openmp/libomptarget/test/offloading/barrier_fence.c
index 5d1096478ed9e..b9a8ca27965a0 100644
--- a/openmp/libomptarget/test/offloading/barrier_fence.c
+++ b/openmp/libomptarget/test/offloading/barrier_fence.c
@@ -7,6 +7,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <omp.h>
 #include <stdio.h>
diff --git a/openmp/libomptarget/test/offloading/bug49334.cpp b/openmp/libomptarget/test/offloading/bug49334.cpp
index a22d3fe9f6653..1f19dab378810 100644
--- a/openmp/libomptarget/test/offloading/bug49334.cpp
+++ b/openmp/libomptarget/test/offloading/bug49334.cpp
@@ -9,6 +9,8 @@
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 // UNSUPPORTED: aarch64-unknown-linux-gnu
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: nvptx64-nvidia-cuda
 // UNSUPPORTED: nvptx64-nvidia-cuda-LTO
diff --git a/openmp/libomptarget/test/offloading/default_thread_limit.c b/openmp/libomptarget/test/offloading/default_thread_limit.c
index d32e7df418cbb..4da02bbb152e6 100644
--- a/openmp/libomptarget/test/offloading/default_thread_limit.c
+++ b/openmp/libomptarget/test/offloading/default_thread_limit.c
@@ -9,6 +9,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 __attribute__((optnone)) int optnone() { return 1; }
 
diff --git a/openmp/libomptarget/test/offloading/ompx_bare.c b/openmp/libomptarget/test/offloading/ompx_bare.c
index fb3810bd1df12..3dabdcd15e0d8 100644
--- a/openmp/libomptarget/test/offloading/ompx_bare.c
+++ b/openmp/libomptarget/test/offloading/ompx_bare.c
@@ -1,10 +1,13 @@
 // RUN: %libomptarget-compile-generic
-// RUN: env LIBOMPTARGET_INFO=63 %libomptarget-run-generic 2>&1 | %fcheck-generic
+// RUN: env LIBOMPTARGET_INFO=63 %libomptarget-run-generic 2>&1 | \
+// RUN:   %fcheck-generic
 //
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 // UNSUPPORTED: aarch64-unknown-linux-gnu
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <assert.h>
 #include <ompx.h>
diff --git a/openmp/libomptarget/test/offloading/ompx_coords.c b/openmp/libomptarget/test/offloading/ompx_coords.c
index 61dad61f46405..5e4e14b4c6dae 100644
--- a/openmp/libomptarget/test/offloading/ompx_coords.c
+++ b/openmp/libomptarget/test/offloading/ompx_coords.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 // UNSUPPORTED: aarch64-unknown-linux-gnu
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <omp.h>
 #include <ompx.h>
diff --git a/openmp/libomptarget/test/offloading/ompx_saxpy_mixed.c b/openmp/libomptarget/test/offloading/ompx_saxpy_mixed.c
index 440b694e3ac70..f479be8a484fc 100644
--- a/openmp/libomptarget/test/offloading/ompx_saxpy_mixed.c
+++ b/openmp/libomptarget/test/offloading/ompx_saxpy_mixed.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 // UNSUPPORTED: aarch64-unknown-linux-gnu
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <math.h>
 #include <omp.h>
diff --git a/openmp/libomptarget/test/offloading/parallel_target_teams_reduction.cpp b/openmp/libomptarget/test/offloading/parallel_target_teams_reduction.cpp
index 5303a9463f155..10e1b33f1ce40 100644
--- a/openmp/libomptarget/test/offloading/parallel_target_teams_reduction.cpp
+++ b/openmp/libomptarget/test/offloading/parallel_target_teams_reduction.cpp
@@ -6,6 +6,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <iostream>
 #include <vector>
diff --git a/openmp/libomptarget/test/offloading/small_trip_count.c b/openmp/libomptarget/test/offloading/small_trip_count.c
index d8bef667607a1..65f094f157469 100644
--- a/openmp/libomptarget/test/offloading/small_trip_count.c
+++ b/openmp/libomptarget/test/offloading/small_trip_count.c
@@ -9,6 +9,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #define N 128
 
diff --git a/openmp/libomptarget/test/offloading/small_trip_count_thread_limit.cpp b/openmp/libomptarget/test/offloading/small_trip_count_thread_limit.cpp
index 9796c2dc11663..b7ae52a62c83b 100644
--- a/openmp/libomptarget/test/offloading/small_trip_count_thread_limit.cpp
+++ b/openmp/libomptarget/test/offloading/small_trip_count_thread_limit.cpp
@@ -7,6 +7,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 int main(int argc, char *argv[]) {
   constexpr const int block_size = 256;
diff --git a/openmp/libomptarget/test/offloading/spmdization.c b/openmp/libomptarget/test/offloading/spmdization.c
index 2cf30ff593b99..77913bec8342f 100644
--- a/openmp/libomptarget/test/offloading/spmdization.c
+++ b/openmp/libomptarget/test/offloading/spmdization.c
@@ -11,6 +11,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 #include <omp.h>
 #include <stdio.h>
diff --git a/openmp/libomptarget/test/offloading/target_critical_region.cpp b/openmp/libomptarget/test/offloading/target_critical_region.cpp
index 9a741bef6c591..495632bf76e17 100644
--- a/openmp/libomptarget/test/offloading/target_critical_region.cpp
+++ b/openmp/libomptarget/test/offloading/target_critical_region.cpp
@@ -6,6 +6,8 @@
 // UNSUPPORTED: nvptx64-nvidia-cuda-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 // UNSUPPORTED: amdgcn-amd-amdhsa
 
 #include <omp.h>
diff --git a/openmp/libomptarget/test/offloading/thread_limit.c b/openmp/libomptarget/test/offloading/thread_limit.c
index 65275a8f27958..a8cc51b651dc9 100644
--- a/openmp/libomptarget/test/offloading/thread_limit.c
+++ b/openmp/libomptarget/test/offloading/thread_limit.c
@@ -9,6 +9,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 int main() {
   int n = 1 << 20;
diff --git a/openmp/libomptarget/test/ompt/target_memcpy.c b/openmp/libomptarget/test/ompt/target_memcpy.c
index 80a8d6a4b32e5..3224c5ac4c916 100644
--- a/openmp/libomptarget/test/ompt/target_memcpy.c
+++ b/openmp/libomptarget/test/ompt/target_memcpy.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Verify that for the target OpenMP APIs, the return address is non-null and
diff --git a/openmp/libomptarget/test/ompt/target_memcpy_emi.c b/openmp/libomptarget/test/ompt/target_memcpy_emi.c
index 5347f38b87b6f..fd7da13cb05d0 100644
--- a/openmp/libomptarget/test/ompt/target_memcpy_emi.c
+++ b/openmp/libomptarget/test/ompt/target_memcpy_emi.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Verify all three data transfer directions: H2D, D2D and D2H
diff --git a/openmp/libomptarget/test/ompt/veccopy.c b/openmp/libomptarget/test/ompt/veccopy.c
index 80e71fd8a48cb..bc70f5a0b5b67 100644
--- a/openmp/libomptarget/test/ompt/veccopy.c
+++ b/openmp/libomptarget/test/ompt/veccopy.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that registers non-EMI callbacks
diff --git a/openmp/libomptarget/test/ompt/veccopy_data.c b/openmp/libomptarget/test/ompt/veccopy_data.c
index cef1de316a7a1..264b484b881f1 100644
--- a/openmp/libomptarget/test/ompt/veccopy_data.c
+++ b/openmp/libomptarget/test/ompt/veccopy_data.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that registers EMI callbacks.
diff --git a/openmp/libomptarget/test/ompt/veccopy_disallow_both.c b/openmp/libomptarget/test/ompt/veccopy_disallow_both.c
index 06293e413ba45..a011c21955bb2 100644
--- a/openmp/libomptarget/test/ompt/veccopy_disallow_both.c
+++ b/openmp/libomptarget/test/ompt/veccopy_disallow_both.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that shows that both EMI and non-EMI
diff --git a/openmp/libomptarget/test/ompt/veccopy_emi.c b/openmp/libomptarget/test/ompt/veccopy_emi.c
index b597d7be6aff6..8718a39b4af81 100644
--- a/openmp/libomptarget/test/ompt/veccopy_emi.c
+++ b/openmp/libomptarget/test/ompt/veccopy_emi.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that registers EMI callbacks
diff --git a/openmp/libomptarget/test/ompt/veccopy_emi_map.c b/openmp/libomptarget/test/ompt/veccopy_emi_map.c
index ce6f6e30d5815..2accba34034e6 100644
--- a/openmp/libomptarget/test/ompt/veccopy_emi_map.c
+++ b/openmp/libomptarget/test/ompt/veccopy_emi_map.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that shows that map-EMI callbacks are not supported.
diff --git a/openmp/libomptarget/test/ompt/veccopy_map.c b/openmp/libomptarget/test/ompt/veccopy_map.c
index 83f63a6e6049e..56a0dd48f5368 100644
--- a/openmp/libomptarget/test/ompt/veccopy_map.c
+++ b/openmp/libomptarget/test/ompt/veccopy_map.c
@@ -4,6 +4,8 @@
 // UNSUPPORTED: aarch64-unknown-linux-gnu-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-LTO
+// UNSUPPORTED: s390x-ibm-linux-gnu
+// UNSUPPORTED: s390x-ibm-linux-gnu-LTO
 
 /*
  * Example OpenMP program that shows that map callbacks are not supported.