diff --git a/llvm/include/llvm/Transforms/Instrumentation/InstrumentorConfig.def b/llvm/include/llvm/Transforms/Instrumentation/InstrumentorConfig.def
index 8e2964811aa4e..d99be04163738 100644
--- a/llvm/include/llvm/Transforms/Instrumentation/InstrumentorConfig.def
+++ b/llvm/include/llvm/Transforms/Instrumentation/InstrumentorConfig.def
@@ -23,6 +23,17 @@ CVALUE(Base, bool, PrintRuntimeSignatures, true)
 
 CVALUE(Base, std::string, StubRuntimePath, "rt.c")
 
+/// Regex string that is matched against the current target.
+/// This target option has the highest precedence. If the target
+/// string doesn't match the regex, it won't be instrumented.
+CVALUE(Base, std::string, EnabledTargetRegex, ".*")
+
+/// Instrument non-GPU targets
+CVALUE(Base, bool, EnabledTargetHost, true)
+
+/// Instrument GPU targets (AMDGPU and NVPTX)
+CVALUE(Base, bool, EnabledTargetGPU, true)
+
 SECTION_END(Base)
 ///}
 
diff --git a/llvm/lib/Transforms/Instrumentation/Instrumentor.cpp b/llvm/lib/Transforms/Instrumentation/Instrumentor.cpp
index 12f61607673fd..3c4ee3bda4e8a 100644
--- a/llvm/lib/Transforms/Instrumentation/Instrumentor.cpp
+++ b/llvm/lib/Transforms/Instrumentation/Instrumentor.cpp
@@ -42,6 +42,7 @@
 #include "llvm/Support/ErrorHandling.h"
 #include "llvm/Support/JSON.h"
 #include "llvm/Support/MemoryBuffer.h"
+#include "llvm/Support/Regex.h"
 #include "llvm/Support/raw_ostream.h"
 #include "llvm/Transforms/Utils/ModuleUtils.h"
 
@@ -456,6 +457,8 @@ class InstrumentorImpl final {
   bool instrumentMainFunction(Function &MainFn, InstrumentorConfig::Position P);
   bool instrumentModule(InstrumentorConfig::Position P);
 
+  bool canInstrumentTarget();
+
   DenseMap<Value *, CallInst *> BasePtrMap;
   bool instrumentBasePointer(Value &ArgOrInst);
   bool removeUnusedBasePointers();
@@ -1705,10 +1708,30 @@ void InstrumentorImpl::addCtorOrDtor(bool Ctor) {
   }
 }
 
+bool InstrumentorImpl::canInstrumentTarget() {
+  const auto TripleStr = M.getTargetTriple();
+  const auto &T = Triple(TripleStr);
+  const bool IsGPU = T.isAMDGPU() || T.isNVPTX();
+  llvm::Regex TargetRegex(IC.Base.EnabledTargetRegex);
+  std::string ErrMsg;
+
+  if (!TargetRegex.isValid(ErrMsg)) {
+    errs() << "WARNING: failed to parse TargetRegex: " << ErrMsg << "\n";
+    return false;
+  }
+
+  return ((IsGPU && IC.Base.EnabledTargetGPU) ||
+          (!IsGPU && IC.Base.EnabledTargetHost)) &&
+         TargetRegex.match(TripleStr);
+}
+
 bool InstrumentorImpl::instrument() {
   bool Changed = false;
   printRuntimeSignatures();
 
+  if (!canInstrumentTarget())
+    return Changed;
+
   Function *MainFn = nullptr;
 
   if (IC.module.isEnabled(InstrumentorConfig::PRE) ||
diff --git a/llvm/test/Instrumentation/Instrumentor/default_config.json b/llvm/test/Instrumentation/Instrumentor/default_config.json
index 7ec3212b450d8..ac38f16859de8 100644
--- a/llvm/test/Instrumentation/Instrumentor/default_config.json
+++ b/llvm/test/Instrumentation/Instrumentor/default_config.json
@@ -2,7 +2,10 @@
   "Base": {
     "RuntimeName": "__instrumentor_",
     "PrintRuntimeSignatures": true,
-    "StubRuntimePath": "rt.c"
+    "StubRuntimePath": "rt.c",
+    "EnabledTargetRegex": ".*",
+    "EnabledTargetHost": true,
+    "EnabledTargetGPU": true
   },
   "alloca": {
     "EnabledPost": true,