diff --git a/static/app/views/settings/project/projectKeys/details/keySettings.spec.tsx b/static/app/views/settings/project/projectKeys/details/keySettings.spec.tsx
index c890bb9a659799..3ba98b42c20a56 100644
--- a/static/app/views/settings/project/projectKeys/details/keySettings.spec.tsx
+++ b/static/app/views/settings/project/projectKeys/details/keySettings.spec.tsx
@@ -16,6 +16,12 @@ const dynamicSdkLoaderOptions = {
   [DynamicSDKLoaderOption.HAS_DEBUG]: false,
 };
 
+const fullDynamicSdkLoaderOptions = {
+  [DynamicSDKLoaderOption.HAS_PERFORMANCE]: true,
+  [DynamicSDKLoaderOption.HAS_REPLAY]: true,
+  [DynamicSDKLoaderOption.HAS_DEBUG]: true,
+};
+
 function renderMockRequests(
   organizationSlug: Organization['slug'],
   projectSlug: Project['slug'],
@@ -120,5 +126,170 @@ describe('Key Settings', function () {
         );
       });
     });
+
+    it('resets performance & replay when selecting SDK version <7', async function () {
+      const params = {
+        projectId: '1',
+        keyId: '1',
+      };
+
+      const {organization} = initializeOrg({
+        ...initializeOrg(),
+        organization: {
+          ...initializeOrg().organization,
+          features: ORG_FEATURES,
+        },
+        router: {
+          params,
+        },
+      });
+
+      const data = {
+        ...(TestStubs.ProjectKeys()[0] as ProjectKey),
+        dynamicSdkLoaderOptions: fullDynamicSdkLoaderOptions,
+      } as ProjectKey;
+
+      const mockRequests = renderMockRequests(
+        organization.slug,
+        params.projectId,
+        params.keyId
+      );
+
+      render(
+        <KeySettings
+          data={data}
+          onRemove={jest.fn()}
+          organization={organization}
+          params={params}
+        />
+      );
+
+      // Update SDK version - should reset performance & replay
+      await selectEvent.select(screen.getByText('latest'), '6.x');
+
+      await waitFor(() => {
+        expect(mockRequests.projectKeys).toHaveBeenCalledWith(
+          `/projects/${organization.slug}/${params.projectId}/keys/${params.keyId}/`,
+          expect.objectContaining({
+            data: {
+              browserSdkVersion: '6.x',
+              dynamicSdkLoaderOptions: {
+                ...fullDynamicSdkLoaderOptions,
+                [DynamicSDKLoaderOption.HAS_PERFORMANCE]: false,
+                [DynamicSDKLoaderOption.HAS_REPLAY]: false,
+                [DynamicSDKLoaderOption.HAS_DEBUG]: true,
+              },
+            },
+          })
+        );
+      });
+    });
+
+    it('disabled performance & replay when SDK version <7 is selected', function () {
+      const params = {
+        projectId: '1',
+        keyId: '1',
+      };
+
+      const {organization} = initializeOrg({
+        ...initializeOrg(),
+        organization: {
+          ...initializeOrg().organization,
+          features: ORG_FEATURES,
+        },
+        router: {
+          params,
+        },
+      });
+
+      const data = {
+        ...(TestStubs.ProjectKeys()[0] as ProjectKey),
+        dynamicSdkLoaderOptions: {
+          [DynamicSDKLoaderOption.HAS_PERFORMANCE]: false,
+          [DynamicSDKLoaderOption.HAS_REPLAY]: false,
+          [DynamicSDKLoaderOption.HAS_DEBUG]: true,
+        },
+        browserSdkVersion: '6.x',
+      } as ProjectKey;
+
+      render(
+        <KeySettings
+          data={data}
+          onRemove={jest.fn()}
+          organization={organization}
+          params={params}
+        />
+      );
+
+      for (const key of Object.keys(sdkLoaderOptions)) {
+        const toggle = screen.getByRole('checkbox', {name: sdkLoaderOptions[key].label});
+
+        if (key === DynamicSDKLoaderOption.HAS_DEBUG) {
+          expect(toggle).toBeEnabled();
+          expect(toggle).toBeChecked();
+        } else {
+          expect(toggle).toBeDisabled();
+          expect(toggle).not.toBeChecked();
+        }
+      }
+
+      const infos = screen.getAllByText('Only available in SDK version 7.x and above');
+      expect(infos.length).toBe(2);
+    });
+
+    it('shows replay message when it is enabled', function () {
+      const params = {
+        projectId: '1',
+        keyId: '1',
+      };
+
+      const {organization} = initializeOrg({
+        ...initializeOrg(),
+        organization: {
+          ...initializeOrg().organization,
+          features: ORG_FEATURES,
+        },
+        router: {
+          params,
+        },
+      });
+
+      const data = {
+        ...(TestStubs.ProjectKeys()[0] as ProjectKey),
+        dynamicSdkLoaderOptions: fullDynamicSdkLoaderOptions,
+      } as ProjectKey;
+
+      const {rerender} = render(
+        <KeySettings
+          data={data}
+          onRemove={jest.fn()}
+          organization={organization}
+          params={params}
+        />
+      );
+
+      expect(
+        screen.queryByText(
+          'When using Replay, the loader will load the ES6 bundle instead of the ES5 bundle.'
+        )
+      ).toBeInTheDocument();
+
+      data.dynamicSdkLoaderOptions.hasReplay = false;
+
+      rerender(
+        <KeySettings
+          data={data}
+          onRemove={jest.fn()}
+          organization={organization}
+          params={params}
+        />
+      );
+
+      expect(
+        screen.queryByText(
+          'When using Replay, the loader will load the ES6 bundle instead of the ES5 bundle.'
+        )
+      ).not.toBeInTheDocument();
+    });
   });
 });
diff --git a/static/app/views/settings/project/projectKeys/details/keySettings.tsx b/static/app/views/settings/project/projectKeys/details/keySettings.tsx
index 151dbf8c48d253..c614fad5d8c29a 100644
--- a/static/app/views/settings/project/projectKeys/details/keySettings.tsx
+++ b/static/app/views/settings/project/projectKeys/details/keySettings.tsx
@@ -51,12 +51,15 @@ export enum DynamicSDKLoaderOption {
 export const sdkLoaderOptions = {
   [DynamicSDKLoaderOption.HAS_PERFORMANCE]: {
     label: t('Enable Performance Monitoring'),
+    requiresV7: true,
   },
   [DynamicSDKLoaderOption.HAS_REPLAY]: {
     label: t('Enable Session Replay'),
+    requiresV7: true,
   },
   [DynamicSDKLoaderOption.HAS_DEBUG]: {
     label: t('Enable Debug Bundles'),
+    requiresV7: false,
   },
 };
 
@@ -145,16 +148,40 @@ export function KeySettings({onRemove, organization, params, data}: Props) {
     async (newBrowserSDKVersion: typeof browserSdkVersion) => {
       addLoadingMessage();
 
+      const apiData: {
+        browserSdkVersion: typeof browserSdkVersion;
+        dynamicSdkLoaderOptions?: Partial<Record<DynamicSDKLoaderOption, boolean>>;
+      } = {
+        browserSdkVersion: newBrowserSDKVersion,
+      };
+
+      const shouldRestrictDynamicSdkLoaderOptions =
+        hasJSSDKDynamicLoaderFeatureFlag &&
+        !sdkVersionSupportsPerformanceAndReplay(newBrowserSDKVersion);
+
+      if (shouldRestrictDynamicSdkLoaderOptions) {
+        // Performance & Replay are not supported before 7.x
+        const newDynamicSdkLoaderOptions = {
+          ...dynamicSDKLoaderOptions,
+          hasPerformance: false,
+          hasReplay: false,
+        };
+
+        apiData.dynamicSdkLoaderOptions = newDynamicSdkLoaderOptions;
+      }
+
       try {
         const response = await api.requestPromise(apiEndpoint, {
           method: 'PUT',
-          data: {
-            browserSdkVersion: newBrowserSDKVersion,
-          },
+          data: apiData,
         });
 
         setBrowserSdkVersion(response.browserSdkVersion);
 
+        if (shouldRestrictDynamicSdkLoaderOptions) {
+          setDynamicSDKLoaderOptions(response.dynamicSdkLoaderOptions);
+        }
+
         addSuccessMessage(t('Successfully updated SDK version'));
       } catch (error) {
         const message = t('Unable to updated SDK version');
@@ -162,7 +189,14 @@ export function KeySettings({onRemove, organization, params, data}: Props) {
         addErrorMessage(message);
       }
     },
-    [api, apiEndpoint, setBrowserSdkVersion]
+    [
+      api,
+      apiEndpoint,
+      setBrowserSdkVersion,
+      setDynamicSDKLoaderOptions,
+      hasJSSDKDynamicLoaderFeatureFlag,
+      dynamicSDKLoaderOptions,
+    ]
   );
 
   return (
@@ -267,14 +301,34 @@ export function KeySettings({onRemove, organization, params, data}: Props) {
                       label={value.label}
                       key={key}
                       name={key}
-                      value={dynamicSDKLoaderOptions[sdkLoaderOption]}
+                      value={
+                        value.requiresV7 &&
+                        !sdkVersionSupportsPerformanceAndReplay(browserSdkVersion)
+                          ? false
+                          : dynamicSDKLoaderOptions[sdkLoaderOption]
+                      }
                       onChange={() =>
                         handleToggleDynamicSDKLoaderOption(
                           sdkLoaderOption as DynamicSDKLoaderOption,
                           !dynamicSDKLoaderOptions[sdkLoaderOption]
                         )
                       }
-                      disabled={!hasAccess}
+                      disabled={
+                        !hasAccess ||
+                        (value.requiresV7 &&
+                          !sdkVersionSupportsPerformanceAndReplay(browserSdkVersion))
+                      }
+                      help={
+                        value.requiresV7 &&
+                        !sdkVersionSupportsPerformanceAndReplay(browserSdkVersion)
+                          ? t('Only available in SDK version 7.x and above')
+                          : key === DynamicSDKLoaderOption.HAS_REPLAY &&
+                            dynamicSDKLoaderOptions[sdkLoaderOption]
+                          ? t(
+                              'When using Replay, the loader will load the ES6 bundle instead of the ES5 bundle.'
+                            )
+                          : undefined
+                      }
                       disabledReason={
                         !hasAccess
                           ? t('You do not have permission to edit this setting')
@@ -337,3 +391,7 @@ export function KeySettings({onRemove, organization, params, data}: Props) {
     </Access>
   );
 }
+
+function sdkVersionSupportsPerformanceAndReplay(sdkVersion: string): boolean {
+  return sdkVersion === 'latest' || sdkVersion === '7.x';
+}