diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4a0ce21803..99e6b4f337 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -44,6 +44,7 @@
 - Skips development server spans ([#4271](https://github.com/getsentry/sentry-react-native/pull/4271))
 - Execute `DebugSymbolicator` after `RewriteFrames` to avoid overwrites by default ([#4285](https://github.com/getsentry/sentry-react-native/pull/4285))
   - If custom `RewriteFrames` is provided the order changes
+- `browserReplayIntegration` is no longer included by default on React Native Web ([#4270](https://github.com/getsentry/sentry-react-native/pull/4270))
 
 ### Dependencies
 
diff --git a/packages/core/src/js/integrations/default.ts b/packages/core/src/js/integrations/default.ts
index 483d1f6f3f..0f32ba6b16 100644
--- a/packages/core/src/js/integrations/default.ts
+++ b/packages/core/src/js/integrations/default.ts
@@ -4,14 +4,13 @@ import type { Integration } from '@sentry/types';
 
 import type { ReactNativeClientOptions } from '../options';
 import { reactNativeTracingIntegration } from '../tracing';
-import { isExpoGo, notWeb } from '../utils/environment';
+import { isExpoGo, isWeb, notWeb } from '../utils/environment';
 import {
   appStartIntegration,
   breadcrumbsIntegration,
   browserApiErrorsIntegration,
   browserGlobalHandlersIntegration,
   browserLinkedErrorsIntegration,
-  browserReplayIntegration,
   createNativeFramesIntegrations,
   createReactNativeRewriteFrames,
   debugSymbolicatorIntegration,
@@ -132,10 +131,13 @@ export function getDefaultIntegrations(options: ReactNativeClientOptions): Integ
     (options._experiments && typeof options._experiments.replaysOnErrorSampleRate === 'number') ||
     (options._experiments && typeof options._experiments.replaysSessionSampleRate === 'number')
   ) {
-    integrations.push(notWeb() ? mobileReplayIntegration() : browserReplayIntegration());
-    if (!notWeb()) {
+    if (isWeb()) {
+      // We can't create and add browserReplayIntegration as it overrides the users supplied one
+      // The browser replay integration works differently than the rest of default integrations
       (options as BrowserOptions).replaysOnErrorSampleRate = options._experiments.replaysOnErrorSampleRate;
       (options as BrowserOptions).replaysSessionSampleRate = options._experiments.replaysSessionSampleRate;
+    } else {
+      integrations.push(mobileReplayIntegration());
     }
   }
 
diff --git a/packages/core/test/sdk.test.ts b/packages/core/test/sdk.test.ts
index 2f9f6e4e69..c78774edea 100644
--- a/packages/core/test/sdk.test.ts
+++ b/packages/core/test/sdk.test.ts
@@ -15,7 +15,7 @@ import { init, withScope } from '../src/js/sdk';
 import type { ReactNativeTracingIntegration } from '../src/js/tracing';
 import { REACT_NATIVE_TRACING_INTEGRATION_NAME, reactNativeTracingIntegration } from '../src/js/tracing';
 import { makeNativeTransport } from '../src/js/transports/native';
-import { getDefaultEnvironment, isExpoGo, notWeb } from '../src/js/utils/environment';
+import { getDefaultEnvironment, isExpoGo, isWeb, notWeb } from '../src/js/utils/environment';
 import { NATIVE } from './mockWrapper';
 import { firstArg, secondArg } from './testutils';
 
@@ -854,6 +854,84 @@ describe('Tests the SDK functionality', () => {
 
     expectIntegration('ExpoContext');
   });
+
+  it('adds mobile replay integration when _experiments.replaysOnErrorSampleRate is set', () => {
+    init({
+      _experiments: {
+        replaysOnErrorSampleRate: 1.0,
+      },
+    });
+
+    expectIntegration('MobileReplay');
+  });
+
+  it('adds mobile replay integration when _experiments.replaysSessionSampleRate is set', () => {
+    init({
+      _experiments: {
+        replaysSessionSampleRate: 1.0,
+      },
+    });
+
+    expectIntegration('MobileReplay');
+  });
+
+  it('does not add mobile replay integration when no replay sample rates are set', () => {
+    init({
+      _experiments: {},
+    });
+
+    expectNotIntegration('MobileReplay');
+  });
+
+  it('does not add any replay integration when on web even with on error sample rate', () => {
+    (isWeb as jest.Mock).mockImplementation(() => true);
+    init({
+      _experiments: {
+        replaysOnErrorSampleRate: 1.0,
+      },
+    });
+
+    expectNotIntegration('Replay');
+    expectNotIntegration('MobileReplay');
+  });
+
+  it('does not add any replay integration when on web even with session sample rate', () => {
+    (isWeb as jest.Mock).mockImplementation(() => true);
+    init({
+      _experiments: {
+        replaysSessionSampleRate: 1.0,
+      },
+    });
+
+    expectNotIntegration('Replay');
+    expectNotIntegration('MobileReplay');
+  });
+
+  it('does not add any replay integration when on web', () => {
+    (isWeb as jest.Mock).mockImplementation(() => true);
+    init({});
+
+    expectNotIntegration('Replay');
+    expectNotIntegration('MobileReplay');
+  });
+
+  it('converts experimental replay options to standard web options when on web', () => {
+    (isWeb as jest.Mock).mockImplementation(() => true);
+    init({
+      _experiments: {
+        replaysOnErrorSampleRate: 0.5,
+        replaysSessionSampleRate: 0.1,
+      },
+    });
+
+    const actualOptions = usedOptions();
+    expect(actualOptions).toEqual(
+      expect.objectContaining({
+        replaysOnErrorSampleRate: 0.5,
+        replaysSessionSampleRate: 0.1,
+      }),
+    );
+  });
 });
 
 function expectIntegration(name: string): void {