diff --git a/packages/browser/src/profiling/utils.ts b/packages/browser/src/profiling/utils.ts
index 4a9a9af1d658..e720a2152f9f 100644
--- a/packages/browser/src/profiling/utils.ts
+++ b/packages/browser/src/profiling/utils.ts
@@ -3,7 +3,7 @@
 import { DEFAULT_ENVIRONMENT, getCurrentHub } from '@sentry/core';
 import type { DebugImage, Envelope, Event, StackFrame, StackParser } from '@sentry/types';
 import type { Profile, ThreadCpuProfile } from '@sentry/types/src/profiling';
-import { forEachEnvelopeItem, GLOBAL_OBJ, logger, uuid4 } from '@sentry/utils';
+import { browserPerformanceTimeOrigin, forEachEnvelopeItem, GLOBAL_OBJ, logger, uuid4 } from '@sentry/utils';
 
 import { WINDOW } from '../helpers';
 import type { JSSelfProfile, JSSelfProfileStack } from './jsSelfProfiling';
@@ -213,6 +213,13 @@ export function convertJSSelfProfileToSampledFormat(input: JSSelfProfile): Profi
 
   // We assert samples.length > 0 above and timestamp should always be present
   const start = input.samples[0].timestamp;
+  // The JS SDK might change it's time origin based on some heuristic (see See packages/utils/src/time.ts)
+  // when that happens, we need to ensure we are correcting the profile timings so the two timelines stay in sync.
+  // Since JS self profiling time origin is always initialized to performance.timeOrigin, we need to adjust for
+  // the drift between the SDK selected value and our profile time origin.
+  const origin =
+    typeof performance.timeOrigin === 'number' ? performance.timeOrigin : browserPerformanceTimeOrigin || 0;
+  const adjustForOriginChange = origin - (browserPerformanceTimeOrigin || origin);
 
   for (let i = 0; i < input.samples.length; i++) {
     const jsSample = input.samples[i];
@@ -227,7 +234,7 @@ export function convertJSSelfProfileToSampledFormat(input: JSSelfProfile): Profi
 
       profile['samples'][i] = {
         // convert ms timestamp to ns
-        elapsed_since_start_ns: ((jsSample.timestamp - start) * MS_TO_NS).toFixed(0),
+        elapsed_since_start_ns: ((jsSample.timestamp + adjustForOriginChange - start) * MS_TO_NS).toFixed(0),
         stack_id: EMPTY_STACK_ID,
         thread_id: THREAD_ID_STRING,
       };
@@ -260,7 +267,7 @@ export function convertJSSelfProfileToSampledFormat(input: JSSelfProfile): Profi
 
     const sample: Profile['profile']['samples'][0] = {
       // convert ms timestamp to ns
-      elapsed_since_start_ns: ((jsSample.timestamp - start) * MS_TO_NS).toFixed(0),
+      elapsed_since_start_ns: ((jsSample.timestamp + adjustForOriginChange - start) * MS_TO_NS).toFixed(0),
       stack_id: STACK_ID,
       thread_id: THREAD_ID_STRING,
     };