diff --git a/packages/nextjs/src/config/templates/apiProxyLoaderTemplate.ts b/packages/nextjs/src/config/templates/apiProxyLoaderTemplate.ts
index 1cd7c40181eb..6aa0782f1233 100644
--- a/packages/nextjs/src/config/templates/apiProxyLoaderTemplate.ts
+++ b/packages/nextjs/src/config/templates/apiProxyLoaderTemplate.ts
@@ -23,7 +23,7 @@ type NextApiModule = (
     }
   // CJS export
   | NextApiHandler
-) & { config?: PageConfig };
+) & { config?: PageConfig & { runtime?: string } };
 
 const userApiModule = origModule as NextApiModule;
 
@@ -53,7 +53,13 @@ export const config = {
   },
 };
 
-export default userProvidedHandler ? Sentry.withSentryAPI(userProvidedHandler, '__ROUTE__') : undefined;
+const isEdgeRuntime = origConfig.runtime === 'experimental-edge';
+
+export default userProvidedHandler
+  ? isEdgeRuntime
+    ? userProvidedHandler
+    : Sentry.withSentryAPI(userProvidedHandler, '__ROUTE__')
+  : undefined;
 
 // Re-export anything exported by the page module we're wrapping. When processing this code, Rollup is smart enough to
 // not include anything whose name matchs something we've explicitly exported above.
diff --git a/packages/nextjs/src/index.client.ts b/packages/nextjs/src/index.client.ts
index 2cabd92a7bcd..a28969824c92 100644
--- a/packages/nextjs/src/index.client.ts
+++ b/packages/nextjs/src/index.client.ts
@@ -2,6 +2,7 @@ import { RewriteFrames } from '@sentry/integrations';
 import { configureScope, init as reactInit, Integrations } from '@sentry/react';
 import { BrowserTracing, defaultRequestInstrumentationOptions, hasTracingEnabled } from '@sentry/tracing';
 import { EventProcessor } from '@sentry/types';
+import { logger } from '@sentry/utils';
 
 import { nextRouterInstrumentation } from './performance/client';
 import { buildMetadata } from './utils/metadata';
@@ -29,10 +30,23 @@ export { BrowserTracing };
 // Treeshakable guard to remove all code related to tracing
 declare const __SENTRY_TRACING__: boolean;
 
+// This is a variable that Next.js will string replace during build with a string if run in an edge runtime from Next.js
+// v12.2.1-canary.3 onwards:
+// https://github.com/vercel/next.js/blob/166e5fb9b92f64c4b5d1f6560a05e2b9778c16fb/packages/next/build/webpack-config.ts#L206
+declare const EdgeRuntime: string | undefined;
+
 type GlobalWithAssetPrefixPath = typeof global & { __rewriteFramesAssetPrefixPath__: string };
 
 /** Inits the Sentry NextJS SDK on the browser with the React SDK. */
 export function init(options: NextjsOptions): void {
+  if (typeof EdgeRuntime === 'string') {
+    // If the SDK is imported when using the Vercel Edge Runtime, it will import the browser SDK, even though it is
+    // running the server part of a Next.js application. We can use the `EdgeRuntime` to check for that case and make
+    // the init call a no-op. This will prevent the SDK from crashing on the Edge Runtime.
+    __DEBUG_BUILD__ && logger.log('Vercel Edge Runtime detected. Will not initialize SDK.');
+    return;
+  }
+
   buildMetadata(options, ['nextjs', 'react']);
   options.environment = options.environment || process.env.NODE_ENV;
   addClientIntegrations(options);
diff --git a/packages/nextjs/src/index.server.ts b/packages/nextjs/src/index.server.ts
index e64349b89c4f..993abbd4cdb8 100644
--- a/packages/nextjs/src/index.server.ts
+++ b/packages/nextjs/src/index.server.ts
@@ -22,6 +22,11 @@ export { ErrorBoundary, showReportDialog, withErrorBoundary } from '@sentry/reac
 type GlobalWithDistDir = typeof global & { __rewriteFramesDistDir__: string };
 const domain = domainModule as typeof domainModule & { active: (domainModule.Domain & Carrier) | null };
 
+// This is a variable that Next.js will string replace during build with a string if run in an edge runtime from Next.js
+// v12.2.1-canary.3 onwards:
+// https://github.com/vercel/next.js/blob/166e5fb9b92f64c4b5d1f6560a05e2b9778c16fb/packages/next/build/webpack-config.ts#L206
+declare const EdgeRuntime: string | undefined;
+
 // Exporting this constant means we can compute it without the linter complaining, even if we stop directly using it in
 // this file. It's important that it be computed as early as possible, because one of its indicators is seeing 'build'
 // (as in the CLI command `next build`) in `process.argv`. Later on in the build process, everything's been spun out
@@ -37,6 +42,11 @@ export function init(options: NextjsOptions): void {
     logger.enable();
   }
 
+  if (typeof EdgeRuntime === 'string') {
+    __DEBUG_BUILD__ && logger.log('Vercel Edge Runtime detected. Will not initialize SDK.');
+    return;
+  }
+
   __DEBUG_BUILD__ && logger.log('Initializing SDK...');
 
   if (sdkAlreadyInitialized()) {