diff --git a/dev-packages/node-integration-tests/suites/express/without-tracing/server.ts b/dev-packages/node-integration-tests/suites/express/without-tracing/server.ts
new file mode 100644
index 000000000000..6b8af4270430
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/without-tracing/server.ts
@@ -0,0 +1,30 @@
+import { loggingTransport } from '@sentry-internal/node-integration-tests';
+import * as Sentry from '@sentry/node';
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  transport: loggingTransport,
+});
+
+import { startExpressServerAndSendPortToRunner } from '@sentry-internal/node-integration-tests';
+import express from 'express';
+
+const app = express();
+
+Sentry.setTag('global', 'tag');
+
+app.get('/test/isolationScope/:id', (req, res) => {
+  const id = req.params.id;
+  Sentry.setTag('isolation-scope', 'tag');
+  Sentry.setTag(`isolation-scope-${id}`, id);
+  Sentry.setTag('isolation-scope-transactionName', `${Sentry.getIsolationScope().getScopeData().transactionName}`);
+
+  Sentry.captureException(new Error('This is an exception'));
+
+  res.send({});
+});
+
+Sentry.setupExpressErrorHandler(app);
+
+startExpressServerAndSendPortToRunner(app);
diff --git a/dev-packages/node-integration-tests/suites/express/without-tracing/test.ts b/dev-packages/node-integration-tests/suites/express/without-tracing/test.ts
new file mode 100644
index 000000000000..85c037dc0df9
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/without-tracing/test.ts
@@ -0,0 +1,49 @@
+import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+
+afterAll(() => {
+  cleanupChildProcesses();
+});
+
+test('correctly applies isolation scope even without tracing', done => {
+  const runner = createRunner(__dirname, 'server.ts')
+    .ignore('session', 'sessions')
+    .expect({
+      event: {
+        tags: {
+          global: 'tag',
+          'isolation-scope': 'tag',
+          'isolation-scope-1': '1',
+          // We can't properly test non-existance of fields here, so we cast this to a string to test it here
+          'isolation-scope-transactionName': 'undefined',
+        },
+        // Request is correctly set
+        request: {
+          url: expect.stringContaining('/test/isolationScope/1'),
+          headers: {
+            'user-agent': expect.stringContaining(''),
+          },
+        },
+      },
+    })
+    .expect({
+      event: {
+        tags: {
+          global: 'tag',
+          'isolation-scope': 'tag',
+          'isolation-scope-2': '2',
+          // We can't properly test non-existance of fields here, so we cast this to a string to test it here
+          'isolation-scope-transactionName': 'undefined',
+        },
+        // Request is correctly set
+        request: {
+          url: expect.stringContaining('/test/isolationScope/2'),
+          headers: {
+            'user-agent': expect.stringContaining(''),
+          },
+        },
+      },
+    })
+    .start(done);
+
+  runner.makeRequest('get', '/test/isolationScope/1').then(() => runner.makeRequest('get', '/test/isolationScope/2'));
+});