diff --git a/dev-packages/node-integration-tests/package.json b/dev-packages/node-integration-tests/package.json
index 5480445e69bb..1594d8e837d0 100644
--- a/dev-packages/node-integration-tests/package.json
+++ b/dev-packages/node-integration-tests/package.json
@@ -16,9 +16,11 @@
     "build:types": "tsc -p tsconfig.types.json",
     "clean": "rimraf -g **/node_modules && run-p clean:script",
     "clean:script": "node scripts/clean.js",
+    "prisma:init": "(cd suites/tracing-experimental/prisma-orm && ts-node ./setup.ts)",
     "lint": "eslint . --format stylish",
     "fix": "eslint . --format stylish --fix",
     "type-check": "tsc",
+    "pretest": "run-s --silent prisma:init",
     "test": "ts-node ./utils/run-tests.ts",
     "jest": "jest --config ./jest.config.js",
     "test:watch": "yarn test --watch"
@@ -28,7 +30,7 @@
     "@nestjs/core": "^10.3.3",
     "@nestjs/common": "^10.3.3",
     "@nestjs/platform-express": "^10.3.3",
-    "@prisma/client": "3.15.2",
+    "@prisma/client": "5.9.1",
     "@sentry/node": "7.100.0",
     "@sentry/tracing": "7.100.0",
     "@sentry/types": "7.100.0",
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/docker-compose.yml b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/docker-compose.yml
new file mode 100644
index 000000000000..45caa4bb3179
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/docker-compose.yml
@@ -0,0 +1,13 @@
+version: '3.9'
+
+services:
+  db:
+    image: postgres:13
+    restart: always
+    container_name: integration-tests-prisma
+    ports:
+      - '5433:5432'
+    environment:
+      POSTGRES_USER: prisma
+      POSTGRES_PASSWORD: prisma
+      POSTGRES_DB: tests
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/package.json b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/package.json
new file mode 100644
index 000000000000..b9a5e7998269
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/package.json
@@ -0,0 +1,22 @@
+{
+  "name": "sentry-prisma-test",
+  "version": "1.0.0",
+  "description": "",
+  "main": "index.js",
+  "engines": {
+    "node": ">=16"
+  },
+  "scripts": {
+    "db-up": "docker-compose up -d",
+    "generate": "prisma generate",
+    "migrate": "prisma migrate dev -n sentry-test",
+    "setup": "run-s --silent db-up generate migrate"
+  },
+  "keywords": [],
+  "author": "",
+  "license": "ISC",
+  "dependencies": {
+    "@prisma/client": "5.9.1",
+    "prisma": "^5.9.1"
+  }
+}
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/migration_lock.toml b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/migration_lock.toml
new file mode 100644
index 000000000000..fbffa92c2bb7
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/migration_lock.toml
@@ -0,0 +1,3 @@
+# Please do not edit this file manually
+# It should be added in your version-control system (i.e. Git)
+provider = "postgresql"
\ No newline at end of file
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/sentry_test/migration.sql b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/sentry_test/migration.sql
new file mode 100644
index 000000000000..8619aaceb2b0
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/migrations/sentry_test/migration.sql
@@ -0,0 +1,12 @@
+-- CreateTable
+CREATE TABLE "User" (
+    "id" SERIAL NOT NULL,
+    "createdAt" TIMESTAMP(3) NOT NULL DEFAULT CURRENT_TIMESTAMP,
+    "email" TEXT NOT NULL,
+    "name" TEXT,
+
+    CONSTRAINT "User_pkey" PRIMARY KEY ("id")
+);
+
+-- CreateIndex
+CREATE UNIQUE INDEX "User_email_key" ON "User"("email");
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/schema.prisma b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/schema.prisma
new file mode 100644
index 000000000000..52682f1b6cf5
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/prisma/schema.prisma
@@ -0,0 +1,16 @@
+datasource db {
+  url      = "postgresql://prisma:prisma@localhost:5433/tests"
+  provider = "postgresql"
+}
+
+generator client {
+  provider = "prisma-client-js"
+  previewFeatures = ["tracing"]
+}
+
+model User {
+  id        Int      @id @default(autoincrement())
+  createdAt DateTime @default(now())
+  email     String   @unique
+  name      String?
+}
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/scenario.js b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/scenario.js
new file mode 100644
index 000000000000..58b46ac1cf3a
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/scenario.js
@@ -0,0 +1,52 @@
+const { randomBytes } = require('crypto');
+/* eslint-disable @typescript-eslint/no-unsafe-member-access */
+const { PrismaClient } = require('@prisma/client');
+const Sentry = require('@sentry/node');
+const { loggingTransport } = require('@sentry-internal/node-integration-tests');
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  tracesSampleRate: 1.0,
+  transport: loggingTransport,
+});
+
+// Stop the process from exiting before the transaction is sent
+setInterval(() => {}, 1000);
+
+async function run() {
+  const client = new PrismaClient();
+
+  await Sentry.startSpan(
+    {
+      name: 'Test Transaction',
+      op: 'transaction',
+    },
+    async span => {
+      await client.user.create({
+        data: {
+          name: 'Tilda',
+          email: `tilda_${randomBytes(4).toString('hex')}@sentry.io`,
+        },
+      });
+
+      await client.user.findMany();
+
+      await client.user.deleteMany({
+        where: {
+          email: {
+            contains: 'sentry.io',
+          },
+        },
+      });
+
+      setTimeout(async () => {
+        span.end();
+        await client.$disconnect();
+      }, 500);
+    },
+  );
+}
+
+// eslint-disable-next-line @typescript-eslint/no-floating-promises
+run();
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/setup.ts b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/setup.ts
new file mode 100755
index 000000000000..a71bec82f893
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/setup.ts
@@ -0,0 +1,18 @@
+import { execSync } from 'child_process';
+import { parseSemver } from '@sentry/utils';
+
+const NODE_VERSION = parseSemver(process.versions.node);
+
+// Prisma v5 requires Node.js v16+
+// https://www.prisma.io/docs/orm/more/upgrade-guides/upgrading-versions/upgrading-to-prisma-5#nodejs-minimum-version-change
+if (NODE_VERSION.major && NODE_VERSION.major < 16) {
+  // eslint-disable-next-line no-console
+  console.warn(`Skipping Prisma tests on Node: ${NODE_VERSION.major}`);
+  process.exit(0);
+}
+
+try {
+  execSync('yarn && yarn setup');
+} catch (_) {
+  process.exit(1);
+}
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/test.ts b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/test.ts
new file mode 100644
index 000000000000..32bcdf168555
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/test.ts
@@ -0,0 +1,112 @@
+import { conditionalTest } from '../../../utils';
+import { createRunner } from '../../../utils/runner';
+
+conditionalTest({ min: 16 })('Prisma ORM Tests', () => {
+  test('CJS - should instrument PostgreSQL queries from Prisma ORM', done => {
+    const EXPECTED_TRANSACTION = {
+      transaction: 'Test Transaction',
+      spans: expect.arrayContaining([
+        expect.objectContaining({
+          data: expect.objectContaining({
+            method: 'create',
+            model: 'User',
+            name: 'User.create',
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:client:operation',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:client:serialize',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:client:connect',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'db.type': 'postgres',
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine:connection',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'db.statement': expect.stringContaining(
+              'INSERT INTO "public"."User" ("createdAt","email","name") VALUES ($1,$2,$3) RETURNING "public"."User"."id", "public"."User"."createdAt", "public"."User"."email", "public"."User"."name" /* traceparent',
+            ),
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine:db_query',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine:serialize',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine:response_json_serialization',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            method: 'findMany',
+            model: 'User',
+            name: 'User.findMany',
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:client:operation',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:client:serialize',
+          status: 'ok',
+        }),
+        expect.objectContaining({
+          data: expect.objectContaining({
+            'otel.kind': 'INTERNAL',
+            'sentry.origin': 'manual',
+          }),
+          description: 'prisma:engine',
+          status: 'ok',
+        }),
+      ]),
+    };
+
+    createRunner(__dirname, 'scenario.js').expect({ transaction: EXPECTED_TRANSACTION }).start(done);
+  });
+});
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/yarn.lock b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/yarn.lock
new file mode 100644
index 000000000000..9c0fc47be4be
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/prisma-orm/yarn.lock
@@ -0,0 +1,51 @@
+# THIS IS AN AUTOGENERATED FILE. DO NOT EDIT THIS FILE DIRECTLY.
+# yarn lockfile v1
+
+
+"@prisma/client@5.9.1":
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/@prisma/client/-/client-5.9.1.tgz#d92bd2f7f006e0316cb4fda9d73f235965cf2c64"
+  integrity sha512-caSOnG4kxcSkhqC/2ShV7rEoWwd3XrftokxJqOCMVvia4NYV/TPtJlS9C2os3Igxw/Qyxumj9GBQzcStzECvtQ==
+
+"@prisma/debug@5.9.1":
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/@prisma/debug/-/debug-5.9.1.tgz#906274e73d3267f88b69459199fa3c51cd9511a3"
+  integrity sha512-yAHFSFCg8KVoL0oRUno3m60GAjsUKYUDkQ+9BA2X2JfVR3kRVSJFc/GpQ2fSORi4pSHZR9orfM4UC9OVXIFFTA==
+
+"@prisma/engines-version@5.9.0-32.23fdc5965b1e05fc54e5f26ed3de66776b93de64":
+  version "5.9.0-32.23fdc5965b1e05fc54e5f26ed3de66776b93de64"
+  resolved "https://registry.yarnpkg.com/@prisma/engines-version/-/engines-version-5.9.0-32.23fdc5965b1e05fc54e5f26ed3de66776b93de64.tgz#54d2164f28d23e09d41cf9eb0bddbbe7f3aaa660"
+  integrity sha512-HFl7275yF0FWbdcNvcSRbbu9JCBSLMcurYwvWc8WGDnpu7APxQo2ONtZrUggU3WxLxUJ2uBX+0GOFIcJeVeOOQ==
+
+"@prisma/engines@5.9.1":
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/@prisma/engines/-/engines-5.9.1.tgz#767539afc6f193a182d0495b30b027f61f279073"
+  integrity sha512-gkdXmjxQ5jktxWNdDA5aZZ6R8rH74JkoKq6LD5mACSvxd2vbqWeWIOV0Py5wFC8vofOYShbt6XUeCIUmrOzOnQ==
+  dependencies:
+    "@prisma/debug" "5.9.1"
+    "@prisma/engines-version" "5.9.0-32.23fdc5965b1e05fc54e5f26ed3de66776b93de64"
+    "@prisma/fetch-engine" "5.9.1"
+    "@prisma/get-platform" "5.9.1"
+
+"@prisma/fetch-engine@5.9.1":
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/@prisma/fetch-engine/-/fetch-engine-5.9.1.tgz#5d3b2c9af54a242e37b3f9561b59ab72f8e92818"
+  integrity sha512-l0goQOMcNVOJs1kAcwqpKq3ylvkD9F04Ioe1oJoCqmz05mw22bNAKKGWuDd3zTUoUZr97va0c/UfLNru+PDmNA==
+  dependencies:
+    "@prisma/debug" "5.9.1"
+    "@prisma/engines-version" "5.9.0-32.23fdc5965b1e05fc54e5f26ed3de66776b93de64"
+    "@prisma/get-platform" "5.9.1"
+
+"@prisma/get-platform@5.9.1":
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/@prisma/get-platform/-/get-platform-5.9.1.tgz#a66bb46ab4d30db786c84150ef074ab0aad4549e"
+  integrity sha512-6OQsNxTyhvG+T2Ksr8FPFpuPeL4r9u0JF0OZHUBI/Uy9SS43sPyAIutt4ZEAyqWQt104ERh70EZedkHZKsnNbg==
+  dependencies:
+    "@prisma/debug" "5.9.1"
+
+prisma@^5.9.1:
+  version "5.9.1"
+  resolved "https://registry.yarnpkg.com/prisma/-/prisma-5.9.1.tgz#baa3dd635fbf71504980978f10f55ea11068f6aa"
+  integrity sha512-Hy/8KJZz0ELtkw4FnG9MS9rNWlXcJhf98Z2QMqi0QiVMoS8PzsBkpla0/Y5hTlob8F3HeECYphBjqmBxrluUrQ==
+  dependencies:
+    "@prisma/engines" "5.9.1"