diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
index 6f672918b33e06..be1fbde77efc9d 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Publish.targets
@@ -70,8 +70,8 @@
       Text="Add a PackageReference for '$(_hostPackageName)' to allow cross-compilation for $(_targetArchitecture)" />
 
     <!-- NativeAOT runtime pack assemblies need to be defined to avoid the default CoreCLR implementations being set as compiler inputs -->
-    <Error Condition="'@(PrivateSdkAssemblies)' == ''" Text="The PrivateSdkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
-    <Error Condition="'@(FrameworkAssemblies)' == ''" Text="The FrameworkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
+    <Error Condition="'@(PrivateSdkAssemblies)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'" Text="The PrivateSdkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
+    <Error Condition="'@(FrameworkAssemblies)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'" Text="The FrameworkAssemblies ItemGroup is required for _ComputeAssembliesToCompileToNative" />
 
     <ComputeManagedAssembliesToCompileToNative
       Assemblies="@(_ResolvedCopyLocalPublishAssets)"
diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Unix.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Unix.targets
index bb457c8c166bc8..6b6b59ab7967b9 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Unix.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.Unix.targets
@@ -53,11 +53,11 @@ The .NET Foundation licenses this file to you under the MIT license.
 
     <ItemGroup>
       <NativeLibrary Condition="'$(IlcMultiModule)' == 'true'" Include="$(SharedLibrary)" />
-      <NativeLibrary Condition="'$(NativeLib)' == '' and '$(CustomNativeMain)' != 'true'" Include="$(IlcSdkPath)libbootstrapper.a" />
-      <NativeLibrary Condition="'$(NativeLib)' != '' or '$(CustomNativeMain)' == 'true'" Include="$(IlcSdkPath)libbootstrapperdll.a" />
-      <NativeLibrary Include="$(IlcSdkPath)$(FullRuntimeName).a" />
-      <NativeLibrary Include="$(IlcSdkPath)$(EventPipeName)$(LibFileExt)" />
-      <NativeLibrary Condition="'$(LinkStandardCPlusPlusLibrary)' != 'true' and '$(StaticICULinking)' != 'true'" Include="$(IlcSdkPath)libstdc++compat.a" />
+      <NativeLibrary Condition="'$(NativeLib)' == '' and '$(CustomNativeMain)' != 'true'" Include="$(IlcFrameworkSdkPath)libbootstrapper.a" />
+      <NativeLibrary Condition="'$(NativeLib)' != '' or '$(CustomNativeMain)' == 'true'" Include="$(IlcFrameworkSdkPath)libbootstrapperdll.a" />
+      <NativeLibrary Include="$(IlcFrameworkSdkPath)$(FullRuntimeName).a" />
+      <NativeLibrary Include="$(IlcFrameworkSdkPath)$(EventPipeName)$(LibFileExt)" />
+      <NativeLibrary Condition="'$(LinkStandardCPlusPlusLibrary)' != 'true' and '$(StaticICULinking)' != 'true'" Include="$(IlcFrameworkSdkPath)libstdc++compat.a" />
     </ItemGroup>
 
     <ItemGroup>
diff --git a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
index fbcadcc71b5977..afa1cc1a66b9fc 100644
--- a/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
+++ b/src/coreclr/nativeaot/BuildIntegration/Microsoft.NETCore.Native.targets
@@ -126,26 +126,41 @@ The .NET Foundation licenses this file to you under the MIT license.
 
   <!-- The properties below need to be defined only after we've found the correct runtime package reference -->
   <Target Name="SetupProperties" DependsOnTargets="$(IlcSetupPropertiesDependsOn)" BeforeTargets="Publish">
+    <ItemGroup>
+      <_NETCoreAppFrameworkReference Include="@(ResolvedFrameworkReference)" Condition="'%(ResolvedFrameworkReference.RuntimePackName)' == 'Microsoft.NETCore.App.Runtime.NativeAOT.$(RuntimeIdentifier)'" />
+    </ItemGroup>
+
     <PropertyGroup>
       <!-- Define paths used in build targets to point to the runtime-specific ILCompiler implementation -->
       <IlcToolsPath Condition="'$(IlcToolsPath)' == ''">$(IlcHostPackagePath)\tools\</IlcToolsPath>
       <IlcSdkPath Condition="'$(IlcSdkPath)' == ''">$(RuntimePackagePath)\sdk\</IlcSdkPath>
-      <IlcFrameworkPath Condition="'$(IlcFrameworkPath)' == ''">$(RuntimePackagePath)\framework\</IlcFrameworkPath>
-      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == ''">$(RuntimePackagePath)\framework\</IlcFrameworkNativePath>
+      <IlcFrameworkPath Condition="'$(IlcFrameworkPath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)\framework\</IlcFrameworkPath>
+      <_NETCoreAppRuntimePackPath>%(_NETCoreAppFrameworkReference.RuntimePackPath)/runtimes/$(RuntimeIdentifier)/</_NETCoreAppRuntimePackPath>
+      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == '' and '$(PublishAotUsingRuntimePack)' == 'true'">$(_NETCoreAppRuntimePackPath)\native\</IlcFrameworkNativePath>
+      <IlcFrameworkNativePath Condition="'$(IlcFrameworkNativePath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(RuntimePackagePath)\framework\</IlcFrameworkNativePath>
+      <IlcFrameworkSdkPath Condition="'$(IlcFrameworkSdkPath)' == '' and '$(PublishAotUsingRuntimePack)' == 'true'">$(IlcFrameworkNativePath)</IlcFrameworkSdkPath>
+      <IlcFrameworkSdkPath Condition="'$(IlcFrameworkSdkPath)' == '' and '$(PublishAotUsingRuntimePack)' != 'true'">$(IlcSdkPath)</IlcFrameworkSdkPath>
       <IlcMibcPath Condition="'$(IlcMibcPath)' == ''">$(RuntimePackagePath)\mibc\</IlcMibcPath>
     </PropertyGroup>
 
-    <ItemGroup>
-      <PrivateSdkAssemblies Include="$(IlcSdkPath)*.dll" />
+    <ItemGroup Condition="'$(PublishAotUsingRuntimePack)' == 'true'">
+      <PrivateSdkAssemblies Include="$(IlcFrameworkSdkPath)*.dll"/>
+      <FrameworkAssemblies Include="@(RuntimePackAsset)" Condition="'%(Extension)' == '.dll'" />
+      <DefaultFrameworkAssemblies Include="@(FrameworkAssemblies)" />
+    </ItemGroup>
 
+    <ItemGroup Condition="'$(PublishAotUsingRuntimePack)' != 'true'">
+      <PrivateSdkAssemblies Include="$(IlcFrameworkSdkPath)*.dll"/>
       <!-- Exclude unmanaged dlls -->
       <FrameworkAssemblies Include="$(IlcFrameworkPath)*.dll" Exclude="$(IlcFrameworkPath)*.Native.dll;$(IlcFrameworkPath)msquic.dll" />
 
-      <MibcFile Include="$(IlcMibcPath)*.mibc" Condition="'$(IlcPgoOptimize)' == 'true'" />
-
       <DefaultFrameworkAssemblies Include="@(FrameworkAssemblies)" />
       <DefaultFrameworkAssemblies Include="@(PrivateSdkAssemblies)" />
     </ItemGroup>
+
+    <ItemGroup>
+      <MibcFile Include="$(IlcMibcPath)*.mibc" Condition="'$(IlcPgoOptimize)' == 'true'" />
+    </ItemGroup>
   </Target>
 
   <Target Name="ComputeIlcCompileInputs" DependsOnTargets="$(IlcDynamicBuildPropertyDependencies)" BeforeTargets="Publish">