diff --git a/2.1/runtime-deps/alpine/amd64/Dockerfile b/2.1/runtime-deps/alpine/amd64/Dockerfile
new file mode 100644
index 0000000..228f3cc
--- /dev/null
+++ b/2.1/runtime-deps/alpine/amd64/Dockerfile
@@ -0,0 +1,22 @@
+FROM alpine:3.6
+
+RUN apk add --no-cache \
+        ca-certificates \
+        \
+        # .NET Core dependencies
+        krb5-libs \
+        libcurl \
+        libgcc \
+        libintl \
+        libssl1.0 \
+        libstdc++ \
+        libunwind \
+        libuuid \
+        tzdata \
+        userspace-rcu \
+        zlib \
+    && apk -X https://dl-cdn.alpinelinux.org/alpine/edge/main add --no-cache \
+        lttng-ust
+
+# Set the invariant mode since icu_libs isn't included (see https://github.com/dotnet/announcements/issues/20)
+ENV DOTNET_SYSTEM_GLOBALIZATION_INVARIANT true
diff --git a/2.1/runtime/alpine/amd64/Dockerfile b/2.1/runtime/alpine/amd64/Dockerfile
new file mode 100644
index 0000000..03164dc
--- /dev/null
+++ b/2.1/runtime/alpine/amd64/Dockerfile
@@ -0,0 +1,16 @@
+FROM microsoft/dotnet-nightly:2.1-runtime-deps-alpine
+
+# Install .NET Core
+ENV DOTNET_VERSION 2.1.0-preview1-25919-02
+ENV DOTNET_DOWNLOAD_URL https://dotnetcli.blob.core.windows.net/dotnet/Runtime/$DOTNET_VERSION/dotnet-runtime-$DOTNET_VERSION-alpine.3.6-x64.tar.gz
+ENV DOTNET_DOWNLOAD_SHA 7a8b081c890226ba7220c654dc833752f837171c2fe449367d24c2980db3a809012478a67423fd46264e5d2f0389a6890077f8dd25a1fc4aeecb25deb84d72a4
+
+RUN apk add --no-cache --virtual .build-deps \
+        openssl \
+    && wget -O dotnet.tar.gz $DOTNET_DOWNLOAD_URL \
+    && echo "$DOTNET_DOWNLOAD_SHA  dotnet.tar.gz" | sha512sum -c - \
+    && mkdir -p /usr/share/dotnet \
+    && tar -C /usr/share/dotnet -xzf dotnet.tar.gz \
+    && ln -s /usr/share/dotnet/dotnet /usr/bin/dotnet \
+    && rm dotnet.tar.gz \
+    && apk del .build-deps
diff --git a/README.md b/README.md
index ddf1eee..ea94149 100644
--- a/README.md
+++ b/README.md
@@ -15,7 +15,9 @@ See [dotnet/dotnet-docker](https://github.com/dotnet/dotnet-docker) for images w
 - [`2.0.3-sdk-stretch`, `2.0-sdk-stretch`, `2.0.3-sdk`, `2.0-sdk`, `2-sdk`, `sdk`, `latest` (*2.0/sdk/stretch/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.0/sdk/stretch/amd64/Dockerfile)
 - [`2.0.3-sdk-jessie`, `2.0-sdk-jessie`, `2-sdk-jessie` (*2.0/sdk/jessie/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.0/sdk/jessie/amd64/Dockerfile)
 - [`2.1.0-preview1-runtime-stretch`, `2.1-runtime-stretch`, `2.1.0-preview1-runtime`, `2.1-runtime` (*2.1/runtime/stretch/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/runtime/stretch/amd64/Dockerfile)
+- [`2.1.0-preview1-runtime-alpine`, `2.1-runtime-alpine` (*2.1/runtime/alpine/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/runtime/alpine/amd64/Dockerfile)
 - [`2.1.0-preview1-runtime-jessie`, `2.1-runtime-jessie` (*2.1/runtime/jessie/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/runtime/jessie/amd64/Dockerfile)
+- [`2.1.0-preview1-runtime-deps-alpine`, `2.1-runtime-deps-alpine` (*2.1/runtime-deps/alpine/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/runtime-deps/alpine/amd64/Dockerfile)
 - [`2.1.0-preview1-sdk-stretch`, `2.1-sdk-stretch`, `2.1.0-preview1-sdk`, `2.1-sdk` (*2.1/sdk/stretch/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/sdk/stretch/amd64/Dockerfile)
 - [`2.1.0-preview1-sdk-jessie`, `2.1-sdk-jessie` (*2.1/sdk/jessie/amd64/Dockerfile*)](https://github.com/dotnet/dotnet-docker-nightly/blob/master/2.1/sdk/jessie/amd64/Dockerfile)
 
diff --git a/manifest.json b/manifest.json
index 43a9611..44b9e62 100644
--- a/manifest.json
+++ b/manifest.json
@@ -369,7 +369,7 @@
           ]
         },
         {
-          "readmeOrder": 12,
+          "readmeOrder": 14,
           "sharedTags": {
             "2.1.0-preview1-sdk": {},
             "2.1-sdk": {}
@@ -403,7 +403,7 @@
           ]
         },
         {
-          "readmeOrder": 11,
+          "readmeOrder": 12,
           "platforms": [
             {
               "dockerfile": "2.1/runtime/jessie/amd64",
@@ -416,7 +416,7 @@
           ]
         },
         {
-          "readmeOrder": 13,
+          "readmeOrder": 15,
           "platforms": [
             {
               "dockerfile": "2.1/sdk/jessie/amd64",
@@ -427,6 +427,32 @@
               }
             }
           ]
+        },
+        {
+          "readmeOrder": 13,
+          "platforms": [
+            {
+              "dockerfile": "2.1/runtime-deps/alpine/amd64",
+              "os": "linux",
+              "tags": {
+                "2.1.0-preview1-runtime-deps-alpine": {},
+                "2.1-runtime-deps-alpine": {}
+              }
+            }
+          ]
+        },
+        {
+          "readmeOrder": 11,
+          "platforms": [
+            {
+              "dockerfile": "2.1/runtime/alpine/amd64",
+              "os": "linux",
+              "tags": {
+                "2.1.0-preview1-runtime-alpine": {},
+                "2.1-runtime-alpine": {}
+              }
+            }
+          ]
         }
       ]
     }
diff --git a/test/Microsoft.DotNet.Docker.Tests/ImageDescriptor.cs b/test/Microsoft.DotNet.Docker.Tests/ImageDescriptor.cs
index 8b7c788..b1496f5 100644
--- a/test/Microsoft.DotNet.Docker.Tests/ImageDescriptor.cs
+++ b/test/Microsoft.DotNet.Docker.Tests/ImageDescriptor.cs
@@ -14,6 +14,7 @@ public class ImageDescriptor
 
         public string Architecture { get; set; } = "amd64";
         public string DotNetCoreVersion { get; set; }
+        public bool IsAlpine { get => String.Equals("alpine", OsVariant, StringComparison.OrdinalIgnoreCase); }
         public bool IsArm { get => String.Equals("arm", Architecture, StringComparison.OrdinalIgnoreCase); }
         public string OsVariant { get; set; }
         public string PlatformOS { get; set; }
diff --git a/test/Microsoft.DotNet.Docker.Tests/ImageTests.cs b/test/Microsoft.DotNet.Docker.Tests/ImageTests.cs
index d666957..feb253b 100644
--- a/test/Microsoft.DotNet.Docker.Tests/ImageTests.cs
+++ b/test/Microsoft.DotNet.Docker.Tests/ImageTests.cs
@@ -44,12 +44,8 @@ public static IEnumerable<object[]> GetVerifyImagesData()
                         Architecture = "arm"
                     },
                     new ImageDescriptor { DotNetCoreVersion = "2.1", RuntimeDepsVersion = "2.0" },
-                    new ImageDescriptor
-                    {
-                        DotNetCoreVersion = "2.1",
-                        RuntimeDepsVersion = "2.0",
-                        OsVariant = "jessie"
-                    },
+                    new ImageDescriptor { DotNetCoreVersion = "2.1", RuntimeDepsVersion = "2.0", OsVariant = "jessie" },
+                    new ImageDescriptor { DotNetCoreVersion = "2.1", OsVariant = "alpine", SdkOsVariant = "", },
                     new ImageDescriptor
                     {
                         DotNetCoreVersion = "2.1",
@@ -112,7 +108,7 @@ public void VerifyImages(ImageDescriptor imageDescriptor)
             {
                 CreateTestAppWithSdkImage(imageDescriptor, appSdkImage);
 
-                if (!imageDescriptor.IsArm)
+                if (!string.IsNullOrEmpty(imageDescriptor.SdkOsVariant))
                 {
                     VerifySdkImage_RunApp(imageDescriptor, appSdkImage);
                 }
@@ -273,6 +269,10 @@ private static string GetRuntimeIdentifier(ImageDescriptor imageDescriptor)
             {
                 rid = "linux-arm";
             }
+            else if (imageDescriptor.IsAlpine)
+            {
+                rid = "alpine.3.6-x64";
+            }
             else if (imageDescriptor.DotNetCoreVersion.StartsWith("1."))
             {
                 rid = "debian.8-x64";