diff --git a/src/Grpc/test/InteropTests/InteropTests.cs b/src/Grpc/test/InteropTests/InteropTests.cs
index b08f491e27a9..2a9a1f66d771 100644
--- a/src/Grpc/test/InteropTests/InteropTests.cs
+++ b/src/Grpc/test/InteropTests/InteropTests.cs
@@ -26,6 +26,7 @@ public InteropTests(ITestOutputHelper output)
         }
 
         [Theory]
+        [QuarantinedTest("https://github.com/dotnet/aspnetcore/issues/22101")]
         [MemberData(nameof(TestCaseData))]
         public async Task InteropTestCase(string name)
         {