diff --git a/pkgs/c_compiler/lib/src/cbuilder/compiler_resolver.dart b/pkgs/c_compiler/lib/src/cbuilder/compiler_resolver.dart
index 9ae3d36eb2..6763f3984d 100644
--- a/pkgs/c_compiler/lib/src/cbuilder/compiler_resolver.dart
+++ b/pkgs/c_compiler/lib/src/cbuilder/compiler_resolver.dart
@@ -174,4 +174,29 @@ class CompilerResolver {
     logger?.finer('No archiver set in config[${BuildConfig.arConfigKey}].');
     return null;
   }
+
+  Future<Uri?> toolchainEnvironmentScript(ToolInstance compiler) async {
+    final fromConfig = buildConfig.toolchainEnvScript;
+    if (fromConfig != null) {
+      logger?.fine('Using toolchainEnvScript from config: $fromConfig');
+      return fromConfig;
+    }
+
+    final compilerTool = compiler.tool;
+    assert(compilerTool == cl);
+    final vcvarsScript =
+        (await vcvars(compiler).defaultResolver!.resolve(logger: logger)).first;
+    return vcvarsScript.uri;
+  }
+
+  List<String>? toolchainEnvironmentScriptArguments() {
+    final fromConfig = buildConfig.toolchainEnvScriptArgs;
+    if (fromConfig != null) {
+      logger?.fine('Using toolchainEnvScriptArgs from config: $fromConfig');
+      return fromConfig;
+    }
+
+    // vcvars above already has x64 or x86 in the script name.
+    return null;
+  }
 }
diff --git a/pkgs/c_compiler/lib/src/cbuilder/run_cbuilder.dart b/pkgs/c_compiler/lib/src/cbuilder/run_cbuilder.dart
index e690f90713..9506ecdc0b 100644
--- a/pkgs/c_compiler/lib/src/cbuilder/run_cbuilder.dart
+++ b/pkgs/c_compiler/lib/src/cbuilder/run_cbuilder.dart
@@ -36,15 +36,12 @@ class RunCBuilder {
                 .length ==
             1);
 
-  Future<ToolInstance> compiler() async {
-    final resolver = CompilerResolver(buildConfig: buildConfig, logger: logger);
-    return await resolver.resolveCompiler();
-  }
+  late final _resolver =
+      CompilerResolver(buildConfig: buildConfig, logger: logger);
 
-  Future<Uri> archiver() async {
-    final resolver = CompilerResolver(buildConfig: buildConfig, logger: logger);
-    return (await resolver.resolveArchiver()).uri;
-  }
+  Future<ToolInstance> compiler() async => await _resolver.resolveCompiler();
+
+  Future<Uri> archiver() async => (await _resolver.resolveArchiver()).uri;
 
   Future<Uri> iosSdk(IOSSdk iosSdk, {Logger? logger}) async {
     if (iosSdk == IOSSdk.iPhoneOs) {
@@ -76,13 +73,7 @@ class RunCBuilder {
       return;
     }
     assert(compilerTool == cl);
-    final vcvarsScript =
-        (await vcvars(compiler_).defaultResolver!.resolve(logger: logger))
-            .first;
-    await runCl(
-      compiler: compiler_.uri,
-      vcvars: vcvarsScript.uri,
-    );
+    await runCl(compiler: compiler_);
   }
 
   Future<void> runClangLike({required Uri compiler}) async {
@@ -146,19 +137,19 @@ class RunCBuilder {
     }
   }
 
-  Future<void> runCl({
-    required Uri compiler,
-    required Uri vcvars,
-  }) async {
+  Future<void> runCl({required ToolInstance compiler}) async {
+    final vcvars = (await _resolver.toolchainEnvironmentScript(compiler))!;
+    final vcvarsArgs = _resolver.toolchainEnvironmentScriptArguments();
+    final environment = await envFromBat(vcvars, arguments: vcvarsArgs ?? []);
+
     final isStaticLib = staticLibrary != null;
     Uri? archiver_;
     if (isStaticLib) {
       archiver_ = await archiver();
     }
 
-    final environment = await envFromBat(vcvars);
     final result = await runProcess(
-      executable: compiler,
+      executable: compiler.uri,
       arguments: [
         if (executable != null) ...[
           ...sources.map((e) => e.toFilePath()),
diff --git a/pkgs/c_compiler/test/cbuilder/cbuilder_test.dart b/pkgs/c_compiler/test/cbuilder/cbuilder_test.dart
index d168e7a640..cabf8e1301 100644
--- a/pkgs/c_compiler/test/cbuilder/cbuilder_test.dart
+++ b/pkgs/c_compiler/test/cbuilder/cbuilder_test.dart
@@ -31,6 +31,8 @@ void main() {
         target: Target.current,
         packaging: PackagingPreference.dynamic, // Ignored by executables.
         cc: cc,
+        toolchainEnvScript: toolchainEnvScript,
+        toolchainEnvScriptArgs: toolchainEnvScriptArgs,
       );
       final buildOutput = BuildOutput();
       final cbuilder = CBuilder.executable(
@@ -70,6 +72,8 @@ void main() {
           target: Target.current,
           packaging: PackagingPreference.dynamic,
           cc: cc,
+          toolchainEnvScript: toolchainEnvScript,
+          toolchainEnvScriptArgs: toolchainEnvScriptArgs,
         );
         final buildOutput = BuildOutput();
 
diff --git a/pkgs/c_compiler/test/cbuilder/compiler_resolver_test.dart b/pkgs/c_compiler/test/cbuilder/compiler_resolver_test.dart
index cb9034b8c9..5dae0159bb 100644
--- a/pkgs/c_compiler/test/cbuilder/compiler_resolver_test.dart
+++ b/pkgs/c_compiler/test/cbuilder/compiler_resolver_test.dart
@@ -9,6 +9,7 @@ import 'package:c_compiler/c_compiler.dart';
 import 'package:c_compiler/src/cbuilder/compiler_resolver.dart';
 import 'package:c_compiler/src/native_toolchain/msvc.dart';
 import 'package:c_compiler/src/tool/tool_error.dart';
+import 'package:collection/collection.dart';
 import 'package:native_assets_cli/native_assets_cli.dart';
 import 'package:test/test.dart';
 
@@ -32,6 +33,9 @@ void main() {
         ...await lib.defaultResolver!.resolve(logger: logger),
         ...await lld.defaultResolver!.resolve(logger: logger),
       ].first.uri;
+      final toolchainEnvScript = [
+        ...await vcvars64.defaultResolver!.resolve(logger: logger)
+      ].firstOrNull?.uri;
       final buildConfig = BuildConfig(
         outDir: tempUri,
         packageRoot: tempUri,
@@ -40,6 +44,7 @@ void main() {
         ar: ar,
         cc: cc,
         ld: ld,
+        toolchainEnvScript: toolchainEnvScript,
       );
       final resolver =
           CompilerResolver(buildConfig: buildConfig, logger: logger);
diff --git a/pkgs/c_compiler/test/helpers.dart b/pkgs/c_compiler/test/helpers.dart
index 3f8d8b94d9..7091ff57e3 100644
--- a/pkgs/c_compiler/test/helpers.dart
+++ b/pkgs/c_compiler/test/helpers.dart
@@ -96,6 +96,16 @@ final Uri? cc = Platform.environment['CC']?.asFileUri();
 /// Linker provided by the environment.
 final Uri? ld = Platform.environment['LD']?.asFileUri();
 
+/// Path to script that sets environment variables for [cc], [ld], and [ar].
+///
+/// Provided by environment.
+final Uri? toolchainEnvScript =
+    Platform.environment['ToolchainEnvScript']?.asFileUri();
+
+/// Arguments for [toolchainEnvScript] provided by environment.
+final List<String>? toolchainEnvScriptArgs =
+    Platform.environment['ToolchainEnvScriptArguments']?.split(' ');
+
 extension on String {
   Uri asFileUri() => Uri.file(this);
 }
diff --git a/pkgs/native_assets_cli/lib/src/model/build_config.dart b/pkgs/native_assets_cli/lib/src/model/build_config.dart
index f097953f09..2d648a6cf9 100644
--- a/pkgs/native_assets_cli/lib/src/model/build_config.dart
+++ b/pkgs/native_assets_cli/lib/src/model/build_config.dart
@@ -47,6 +47,14 @@ class BuildConfig {
   Uri? get ar => _ar;
   late final Uri? _ar;
 
+  /// Path to script that sets environment variables for [cc], [ld], and [ar].
+  Uri? get toolchainEnvScript => _toolchainEnvScript;
+  late final Uri? _toolchainEnvScript;
+
+  /// Arguments for [toolchainEnvScript].
+  List<String>? get toolchainEnvScriptArgs => _toolchainEnvScriptArgs;
+  late final List<String>? _toolchainEnvScriptArgs;
+
   /// Preferred packaging method for library.
   PackagingPreference get packaging => _packaging;
   late final PackagingPreference _packaging;
@@ -73,6 +81,8 @@ class BuildConfig {
     Uri? ar,
     Uri? cc,
     Uri? ld,
+    Uri? toolchainEnvScript,
+    List<String>? toolchainEnvScriptArgs,
     required PackagingPreference packaging,
     Map<String, Metadata>? dependencyMetadata,
   }) {
@@ -84,6 +94,8 @@ class BuildConfig {
       .._ar = ar
       .._cc = cc
       .._ld = ld
+      .._toolchainEnvScript = toolchainEnvScript
+      .._toolchainEnvScriptArgs = toolchainEnvScriptArgs
       .._packaging = packaging
       .._dependencyMetadata = dependencyMetadata;
     final parsedConfigFile = nonValidated.toYaml();
@@ -143,10 +155,14 @@ class BuildConfig {
   static const arConfigKey = 'ar';
   static const ccConfigKey = 'cc';
   static const ldConfigKey = 'ld';
+  static const toolchainEnvScriptConfigKey = 'toolchain_env_script';
+  static const toolchainEnvScriptArgsConfigKey =
+      'toolchain_env_script_arguments';
   static const dependencyMetadataConfigKey = 'dependency_metadata';
 
   List<void Function(Config)> _readFieldsFromConfig() {
     var targetSet = false;
+    var ccSet = false;
     return [
       (config) => _config = config,
       (config) => _outDir = config.path(outDirConfigKey),
@@ -169,8 +185,19 @@ class BuildConfig {
             )
           : null,
       (config) => _ar = config.optionalPath(arConfigKey, mustExist: true),
-      (config) => _cc = config.optionalPath(ccConfigKey, mustExist: true),
+      (config) {
+        _cc = config.optionalPath(ccConfigKey, mustExist: true);
+        ccSet = true;
+      },
       (config) => _ld = config.optionalPath(ldConfigKey, mustExist: true),
+      (config) => _toolchainEnvScript =
+          (ccSet && cc != null && cc!.toFilePath().endsWith('cl.exe'))
+              ? config.path(toolchainEnvScriptConfigKey, mustExist: true)
+              : null,
+      (config) => _toolchainEnvScriptArgs = config.optionalStringList(
+            toolchainEnvScriptArgsConfigKey,
+            splitEnvironmentPattern: ' ',
+          ),
       (config) => _packaging = PackagingPreference.fromString(
             config.string(
               PackagingPreference.configKey,
@@ -218,6 +245,10 @@ class BuildConfig {
         if (_ar != null) arConfigKey: _ar!.toFilePath(),
         if (_cc != null) ccConfigKey: _cc!.toFilePath(),
         if (_ld != null) ldConfigKey: _ld!.toFilePath(),
+        if (_toolchainEnvScript != null)
+          toolchainEnvScriptConfigKey: _toolchainEnvScript!.toFilePath(),
+        if (_toolchainEnvScriptArgs != null)
+          toolchainEnvScriptArgsConfigKey: _toolchainEnvScriptArgs!,
         PackagingPreference.configKey: _packaging.toString(),
         if (_dependencyMetadata != null)
           dependencyMetadataConfigKey: {
@@ -240,6 +271,9 @@ class BuildConfig {
     if (other._ar != _ar) return false;
     if (other._cc != _cc) return false;
     if (other._ld != _ld) return false;
+    if (other.toolchainEnvScript != toolchainEnvScript) return false;
+    if (!ListEquality<String>().equals(
+        other.toolchainEnvScriptArgs, toolchainEnvScriptArgs)) return false;
     if (other._packaging != _packaging) return false;
     if (!DeepCollectionEquality()
         .equals(other._dependencyMetadata, _dependencyMetadata)) return false;
@@ -255,6 +289,8 @@ class BuildConfig {
         _ar,
         _cc,
         _ld,
+        _toolchainEnvScript,
+        ListEquality<String>().hash(toolchainEnvScriptArgs),
         _packaging,
         DeepCollectionEquality().hash(_dependencyMetadata),
       );
diff --git a/pkgs/native_assets_cli/test/example/native_add_test.dart b/pkgs/native_assets_cli/test/example/native_add_test.dart
index 7faacf31a5..7e0f355b47 100644
--- a/pkgs/native_assets_cli/test/example/native_add_test.dart
+++ b/pkgs/native_assets_cli/test/example/native_add_test.dart
@@ -35,6 +35,12 @@ void main() async {
         '-Dtarget=${Target.current}',
         '-Dpackaging=dynamic',
         if (cc != null) '-Dcc=${cc!.toFilePath()}',
+        if (toolchainEnvScript != null)
+          '-D${BuildConfig.toolchainEnvScriptConfigKey}='
+              '${toolchainEnvScript!.toFilePath()}',
+        if (toolchainEnvScriptArgs != null)
+          '-D${BuildConfig.toolchainEnvScriptArgsConfigKey}='
+              '${toolchainEnvScriptArgs!.join(' ')}',
       ],
       workingDirectory: testPackageUri.toFilePath(),
     );
diff --git a/pkgs/native_assets_cli/test/helpers.dart b/pkgs/native_assets_cli/test/helpers.dart
index 5e2b000627..513af3d4a8 100644
--- a/pkgs/native_assets_cli/test/helpers.dart
+++ b/pkgs/native_assets_cli/test/helpers.dart
@@ -56,6 +56,16 @@ final Uri? cc = Platform.environment['CC']?.asFileUri();
 /// Linker provided by the environment.
 final Uri? ld = Platform.environment['LD']?.asFileUri();
 
+/// Path to script that sets environment variables for [cc], [ld], and [ar].
+///
+/// Provided by environment.
+final Uri? toolchainEnvScript =
+    Platform.environment['ToolchainEnvScript']?.asFileUri();
+
+/// Arguments for [toolchainEnvScript] provided by environment.
+final List<String>? toolchainEnvScriptArgs =
+    Platform.environment['ToolchainEnvScriptArguments']?.split(' ');
+
 extension on String {
   Uri asFileUri() => Uri.file(this);
 }
diff --git a/pkgs/native_assets_cli/test/model/build_config_test.dart b/pkgs/native_assets_cli/test/model/build_config_test.dart
index 7eeada8b98..15f745f11d 100644
--- a/pkgs/native_assets_cli/test/model/build_config_test.dart
+++ b/pkgs/native_assets_cli/test/model/build_config_test.dart
@@ -13,6 +13,8 @@ void main() async {
   late Uri fakeClang;
   late Uri fakeLd;
   late Uri fakeAr;
+  late Uri fakeCl;
+  late Uri fakeVcVars;
 
   setUp(() async {
     tempUri = (await Directory.systemTemp.createTemp()).uri;
@@ -22,6 +24,10 @@ void main() async {
     await File.fromUri(fakeLd).create();
     fakeAr = tempUri.resolve('fake_ar');
     await File.fromUri(fakeAr).create();
+    fakeCl = tempUri.resolve('cl.exe');
+    await File.fromUri(fakeCl).create();
+    fakeVcVars = tempUri.resolve('vcvarsall.bat');
+    await File.fromUri(fakeVcVars).create();
   });
 
   tearDown(() async {
@@ -275,4 +281,21 @@ target_ios_sdk: iphoneos''';
       'value',
     );
   });
+
+  test('toolchainEnvScript', () {
+    final buildConfig1 = BuildConfig(
+      outDir: tempUri.resolve('out1/'),
+      packageRoot: tempUri.resolve('packageRoot/'),
+      target: Target.windowsX64,
+      cc: fakeCl,
+      toolchainEnvScript: fakeVcVars,
+      toolchainEnvScriptArgs: ['x64'],
+      packaging: PackagingPreference.dynamic,
+    );
+
+    final configFile = buildConfig1.toYaml();
+    final config = Config(fileParsed: configFile);
+    final fromConfig = BuildConfig.fromConfig(config);
+    expect(fromConfig, equals(buildConfig1));
+  });
 }