diff --git a/common/utils/src/main/resources/error/error-conditions.json b/common/utils/src/main/resources/error/error-conditions.json
index 38472f44fb59..57b3d33741e9 100644
--- a/common/utils/src/main/resources/error/error-conditions.json
+++ b/common/utils/src/main/resources/error/error-conditions.json
@@ -5330,6 +5330,11 @@
           "<treeNode>"
         ]
       },
+      "SCALAR_SUBQUERY_IN_VALUES" : {
+        "message" : [
+          "Scalar subqueries in the VALUES clause."
+        ]
+      },
       "UNSUPPORTED_CORRELATED_EXPRESSION_IN_JOIN_CONDITION" : {
         "message" : [
           "Correlated subqueries in the join predicate cannot reference both join inputs:",
diff --git a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
index a9fbe548ba39..752ff49e1f90 100644
--- a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
+++ b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/analysis/CheckAnalysis.scala
@@ -250,6 +250,9 @@ trait CheckAnalysis extends PredicateHelper with LookupCatalog with QueryErrorsB
           context = u.origin.getQueryContext,
           summary = u.origin.context.summary)
 
+      case u: UnresolvedInlineTable if unresolvedInlineTableContainsScalarSubquery(u) =>
+        throw QueryCompilationErrors.inlineTableContainsScalarSubquery(u)
+
       case command: V2PartitionCommand =>
         command.table match {
           case r @ ResolvedTable(_, _, table, _) => table match {
@@ -1559,6 +1562,15 @@ trait CheckAnalysis extends PredicateHelper with LookupCatalog with QueryErrorsB
       case _ =>
     }
   }
+
+  private def unresolvedInlineTableContainsScalarSubquery(
+      unresolvedInlineTable: UnresolvedInlineTable) = {
+    unresolvedInlineTable.rows.exists { row =>
+      row.exists { expression =>
+        expression.exists(_.isInstanceOf[ScalarSubquery])
+      }
+    }
+  }
 }
 
 // a heap of the preempted error that only keeps the top priority element, representing the sole
diff --git a/sql/catalyst/src/main/scala/org/apache/spark/sql/errors/QueryCompilationErrors.scala b/sql/catalyst/src/main/scala/org/apache/spark/sql/errors/QueryCompilationErrors.scala
index f1f8be3d1575..f268ef85ef1d 100644
--- a/sql/catalyst/src/main/scala/org/apache/spark/sql/errors/QueryCompilationErrors.scala
+++ b/sql/catalyst/src/main/scala/org/apache/spark/sql/errors/QueryCompilationErrors.scala
@@ -4112,4 +4112,12 @@ private[sql] object QueryCompilationErrors extends QueryErrorsBase with Compilat
         "expr" -> expr.toString),
       origin = expr.origin)
   }
+
+  def inlineTableContainsScalarSubquery(inlineTable: LogicalPlan): Throwable = {
+    new AnalysisException(
+      errorClass = "UNSUPPORTED_SUBQUERY_EXPRESSION_CATEGORY.SCALAR_SUBQUERY_IN_VALUES",
+      messageParameters = Map.empty,
+      origin = inlineTable.origin
+    )
+  }
 }
diff --git a/sql/core/src/test/scala/org/apache/spark/sql/SQLQuerySuite.scala b/sql/core/src/test/scala/org/apache/spark/sql/SQLQuerySuite.scala
index b7d0039446f3..9beceda26379 100644
--- a/sql/core/src/test/scala/org/apache/spark/sql/SQLQuerySuite.scala
+++ b/sql/core/src/test/scala/org/apache/spark/sql/SQLQuerySuite.scala
@@ -4909,6 +4909,21 @@ class SQLQuerySuite extends QueryTest with SharedSparkSession with AdaptiveSpark
       )
     }
   }
+
+  test("SPARK-49659: Unsupported scalar subqueries in VALUES") {
+    checkError(
+      exception = intercept[AnalysisException](
+        sql("SELECT * FROM VALUES ((SELECT 1) + (SELECT 2))")
+      ),
+      condition = "UNSUPPORTED_SUBQUERY_EXPRESSION_CATEGORY.SCALAR_SUBQUERY_IN_VALUES",
+      parameters = Map(),
+      context = ExpectedContext(
+        fragment = "VALUES ((SELECT 1) + (SELECT 2))",
+        start = 14,
+        stop = 45
+      )
+    )
+  }
 }
 
 case class Foo(bar: Option[String])