diff --git a/core/src/main/java/com/datastax/oss/driver/internal/core/cql/DefaultBoundStatement.java b/core/src/main/java/com/datastax/oss/driver/internal/core/cql/DefaultBoundStatement.java
index 4e0b8af3fac..6b404541224 100644
--- a/core/src/main/java/com/datastax/oss/driver/internal/core/cql/DefaultBoundStatement.java
+++ b/core/src/main/java/com/datastax/oss/driver/internal/core/cql/DefaultBoundStatement.java
@@ -358,7 +358,8 @@ public ByteBuffer getRoutingKey() {
       if (indices.isEmpty()) {
         return null;
       } else if (indices.size() == 1) {
-        return getBytesUnsafe(indices.get(0));
+        int index = indices.get(0);
+        return isSet(index) ? getBytesUnsafe(index) : null;
       } else {
         ByteBuffer[] components = new ByteBuffer[indices.size()];
         for (int i = 0; i < components.length; i++) {
diff --git a/integration-tests/src/test/java/com/datastax/oss/driver/core/cql/PreparedStatementIT.java b/integration-tests/src/test/java/com/datastax/oss/driver/core/cql/PreparedStatementIT.java
index 1b07edb53af..ddab089f871 100644
--- a/integration-tests/src/test/java/com/datastax/oss/driver/core/cql/PreparedStatementIT.java
+++ b/integration-tests/src/test/java/com/datastax/oss/driver/core/cql/PreparedStatementIT.java
@@ -475,6 +475,25 @@ private void should_infer_routing_information_when_partition_key_is_bound(String
     assertThat(tokenFactory.hash(boundStatement.getRoutingKey())).isEqualTo(expectedToken);
   }
 
+  @Test
+  public void should_return_null_routing_information_when_single_partition_key_is_unbound() {
+    should_return_null_routing_information_when_single_partition_key_is_unbound(
+        "SELECT a FROM prepared_statement_test WHERE a = ?");
+    should_return_null_routing_information_when_single_partition_key_is_unbound(
+        "INSERT INTO prepared_statement_test (a) VALUES (?)");
+    should_return_null_routing_information_when_single_partition_key_is_unbound(
+        "UPDATE prepared_statement_test SET b = 1 WHERE a = ?");
+    should_return_null_routing_information_when_single_partition_key_is_unbound(
+        "DELETE FROM prepared_statement_test WHERE a = ?");
+  }
+
+  private void should_return_null_routing_information_when_single_partition_key_is_unbound(
+      String queryString) {
+    CqlSession session = sessionRule.session();
+    BoundStatement boundStatement = session.prepare(queryString).bind();
+    assertThat(boundStatement.getRoutingKey()).isNull();
+  }
+
   private static Iterable<Row> firstPageOf(CompletionStage<AsyncResultSet> stage) {
     return CompletableFutures.getUninterruptibly(stage).currentPage();
   }