diff --git a/src/cdk/scrolling/virtual-scroll-viewport.ts b/src/cdk/scrolling/virtual-scroll-viewport.ts
index 6eabf6c10190..7266e24db197 100644
--- a/src/cdk/scrolling/virtual-scroll-viewport.ts
+++ b/src/cdk/scrolling/virtual-scroll-viewport.ts
@@ -8,7 +8,9 @@
 
 import {Directionality} from '@angular/cdk/bidi';
 import {ListRange} from '@angular/cdk/collections';
+import {Platform} from '@angular/cdk/platform';
 import {
+  afterNextRender,
   booleanAttribute,
   ChangeDetectionStrategy,
   ChangeDetectorRef,
@@ -16,6 +18,7 @@ import {
   ElementRef,
   inject,
   Inject,
+  Injector,
   Input,
   NgZone,
   OnDestroy,
@@ -25,21 +28,20 @@ import {
   ViewChild,
   ViewEncapsulation,
 } from '@angular/core';
-import {Platform} from '@angular/cdk/platform';
 import {
   animationFrameScheduler,
   asapScheduler,
   Observable,
-  Subject,
   Observer,
+  Subject,
   Subscription,
 } from 'rxjs';
 import {auditTime, startWith, takeUntil} from 'rxjs/operators';
 import {ScrollDispatcher} from './scroll-dispatcher';
 import {CdkScrollable, ExtendedScrollToOptions} from './scrollable';
-import {VIRTUAL_SCROLL_STRATEGY, VirtualScrollStrategy} from './virtual-scroll-strategy';
 import {ViewportRuler} from './viewport-ruler';
 import {CdkVirtualScrollRepeater} from './virtual-scroll-repeater';
+import {VIRTUAL_SCROLL_STRATEGY, VirtualScrollStrategy} from './virtual-scroll-strategy';
 import {CdkVirtualScrollable, VIRTUAL_SCROLLABLE} from './virtual-scrollable';
 
 /** Checks if the given ranges are equal. */
@@ -173,6 +175,10 @@ export class CdkVirtualScrollViewport extends CdkVirtualScrollable implements On
   /** Subscription to changes in the viewport size. */
   private _viewportChanges = Subscription.EMPTY;
 
+  private _injector = inject(Injector);
+
+  private _isDestroyed = false;
+
   constructor(
     public override elementRef: ElementRef<HTMLElement>,
     private _changeDetectorRef: ChangeDetectorRef,
@@ -250,6 +256,8 @@ export class CdkVirtualScrollViewport extends CdkVirtualScrollable implements On
     this._detachedSubject.complete();
     this._viewportChanges.unsubscribe();
 
+    this._isDestroyed = true;
+
     super.ngOnDestroy();
   }
 
@@ -498,23 +506,34 @@ export class CdkVirtualScrollViewport extends CdkVirtualScrollable implements On
 
   /** Run change detection. */
   private _doChangeDetection() {
-    this._isChangeDetectionPending = false;
-
-    // Apply the content transform. The transform can't be set via an Angular binding because
-    // bypassSecurityTrustStyle is banned in Google. However the value is safe, it's composed of
-    // string literals, a variable that can only be 'X' or 'Y', and user input that is run through
-    // the `Number` function first to coerce it to a numeric value.
-    this._contentWrapper.nativeElement.style.transform = this._renderedContentTransform;
-    // Apply changes to Angular bindings. Note: We must call `markForCheck` to run change detection
-    // from the root, since the repeated items are content projected in. Calling `detectChanges`
-    // instead does not properly check the projected content.
-    this.ngZone.run(() => this._changeDetectorRef.markForCheck());
-
-    const runAfterChangeDetection = this._runAfterChangeDetection;
-    this._runAfterChangeDetection = [];
-    for (const fn of runAfterChangeDetection) {
-      fn();
+    if (this._isDestroyed) {
+      return;
     }
+
+    this.ngZone.run(() => {
+      // Apply changes to Angular bindings. Note: We must call `markForCheck` to run change detection
+      // from the root, since the repeated items are content projected in. Calling `detectChanges`
+      // instead does not properly check the projected content.
+      this._changeDetectorRef.markForCheck();
+
+      // Apply the content transform. The transform can't be set via an Angular binding because
+      // bypassSecurityTrustStyle is banned in Google. However the value is safe, it's composed of
+      // string literals, a variable that can only be 'X' or 'Y', and user input that is run through
+      // the `Number` function first to coerce it to a numeric value.
+      this._contentWrapper.nativeElement.style.transform = this._renderedContentTransform;
+
+      afterNextRender(
+        () => {
+          this._isChangeDetectionPending = false;
+          const runAfterChangeDetection = this._runAfterChangeDetection;
+          this._runAfterChangeDetection = [];
+          for (const fn of runAfterChangeDetection) {
+            fn();
+          }
+        },
+        {injector: this._injector},
+      );
+    });
   }
 
   /** Calculates the `style.width` and `style.height` for the spacer element. */
diff --git a/src/dev-app/main.ts b/src/dev-app/main.ts
index 8f0ab1aa010e..0c5ceb7cf76f 100644
--- a/src/dev-app/main.ts
+++ b/src/dev-app/main.ts
@@ -53,6 +53,6 @@ bootstrapApplication(DevApp, {
     {provide: Directionality, useClass: DevAppDirectionality},
     cachedAppState.zoneless
       ? provideExperimentalZonelessChangeDetection()
-      : provideZoneChangeDetection({eventCoalescing: true}),
+      : provideZoneChangeDetection({eventCoalescing: true, runCoalescing: true}),
   ],
 });