diff --git a/goldens/size-test.yaml b/goldens/size-test.yaml
index 74acb5d334f8..d9e29c2b69ae 100644
--- a/goldens/size-test.yaml
+++ b/goldens/size-test.yaml
@@ -1,18 +1,18 @@
-cdk/drag-drop/all-directives: 160859
-cdk/drag-drop/basic: 158225
-material-experimental/mdc-chips/basic: 385551
-material-experimental/mdc-form-field/advanced: 417584
-material-experimental/mdc-form-field/basic: 416339
-material/autocomplete/without-optgroup: 392028
-material/button-toggle/standalone: 124412
-material/chips/basic: 320073
-material/datepicker/range-picker/without-form-field: 505044
-material/expansion/without-accordion: 330526
-material/form-field/advanced: 377468
-material/form-field/basic: 376144
-material/list/nav-list: 328072
-material/menu/without-lazy-content: 398590
-material/radio/without-group: 127571
-material/select/basic: 437305
-material/tabs/advanced: 369608
-material/tabs/basic: 368747
+cdk/drag-drop/all-directives: 155091
+cdk/drag-drop/basic: 152522
+material-experimental/mdc-chips/basic: 249660
+material-experimental/mdc-form-field/advanced: 296409
+material-experimental/mdc-form-field/basic: 294855
+material/autocomplete/without-optgroup: 281544
+material/button-toggle/standalone: 186619
+material/chips/basic: 228157
+material/datepicker/range-picker/without-form-field: 398783
+material/expansion/without-accordion: 200184
+material/form-field/advanced: 247973
+material/form-field/basic: 246355
+material/list/nav-list: 194468
+material/menu/without-lazy-content: 286831
+material/radio/without-group: 189803
+material/select/basic: 329893
+material/tabs/advanced: 248653
+material/tabs/basic: 247787
diff --git a/integration/size-test/BUILD.bazel b/integration/size-test/BUILD.bazel
index ecd3817d7448..b8252c3f4cbf 100644
--- a/integration/size-test/BUILD.bazel
+++ b/integration/size-test/BUILD.bazel
@@ -1,3 +1,4 @@
+load("@npm//@bazel/esbuild:index.bzl", "esbuild_config")
 load("//tools:defaults.bzl", "ts_library")
 
 package(default_visibility = ["//visibility:public"])
@@ -8,6 +9,16 @@ exports_files([
     "index-tmpl.ts",
 ])
 
+esbuild_config(
+    name = "esbuild_config",
+    config_file = "esbuild.config.mjs",
+    deps = [
+        "@npm//@angular-devkit/build-angular",
+        "@npm//@angular/compiler-cli",
+        "@npm//@babel/core",
+    ],
+)
+
 ts_library(
     name = "check-size",
     srcs = ["check-size.ts"],
diff --git a/integration/size-test/esbuild.config.mjs b/integration/size-test/esbuild.config.mjs
new file mode 100644
index 000000000000..cbfef364c0f5
--- /dev/null
+++ b/integration/size-test/esbuild.config.mjs
@@ -0,0 +1,90 @@
+/**
+ * @license
+ * Copyright Google LLC All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.io/license
+ */
+
+import babel from '@babel/core';
+import {createEs2015LinkerPlugin} from '@angular/compiler-cli/linker/babel';
+import {ConsoleLogger, NodeJSFileSystem, LogLevel} from '@angular/compiler-cli';
+import {GLOBAL_DEFS_FOR_TERSER_WITH_AOT} from '@angular/compiler-cli/private/tooling';
+import adjustStaticClassMembersPlugin from '@angular-devkit/build-angular/src/babel/plugins/adjust-static-class-members.js';
+import elideAngularMetadataPlugin from '@angular-devkit/build-angular/src/babel/plugins/elide-angular-metadata.js';
+import adjustTypeScriptEnumsPlugin from '@angular-devkit/build-angular/src/babel/plugins/adjust-typescript-enums.js';
+import pureToplevelFunctionsPlugin from '@angular-devkit/build-angular/src/babel/plugins/pure-toplevel-functions.js';
+import fs from 'fs';
+
+/** Babel plugin running the Angular linker. */
+const linkerBabelPlugin = createEs2015LinkerPlugin({
+  fileSystem: new NodeJSFileSystem(),
+  logger: new ConsoleLogger(LogLevel.warn),
+  linkerJitMode: false,
+});
+
+/**
+ * ESBuild plugin configuring various optimization Babel plugins. The Babel plugins
+ * configured as part of this plugin run in the Angular CLI compilation pipeline as well.
+ */
+const esbuildBabelOptimizePlugin = {
+  name: 'ng-babel-optimize-esbuild',
+  setup: build => {
+    build.onLoad({filter: /.*/}, async args => {
+      const filePath = args.path;
+      const content = await fs.promises.readFile(filePath, 'utf8');
+      const plugins = [
+        linkerBabelPlugin,
+        adjustStaticClassMembersPlugin,
+        elideAngularMetadataPlugin,
+        adjustTypeScriptEnumsPlugin,
+      ];
+
+      // All files except for the auto-generated module entry-point are considered side-effect
+      // free. For these we can add the pure-top level Babel plugin. This matches conceptually
+      // with what is done in the Angular CLI compilation pipeline, with respect to everything
+      // in this repo being an official side-effect free APF package.
+      if (!args.path.includes('autogenerated_module_index.mjs')) {
+        plugins.push(pureToplevelFunctionsPlugin);
+      }
+
+      const {code} = await babel.transformAsync(content, {
+        filename: filePath,
+        filenameRelative: filePath,
+        plugins: plugins,
+        // Sourcemaps are generated inline so that ESBuild can process them.
+        sourceMaps: 'inline',
+        compact: false,
+      });
+
+      return {contents: code};
+    });
+  },
+};
+
+export default {
+  // Note: We prefer `.mjs` here as this is the extension used by Angular APF packages.
+  resolveExtensions: ['.mjs', '.js'],
+  conditions: ['es2020', 'es2015'],
+  mainFields: ['fesm2020', 'es2020', 'es2015', 'module'],
+  format: 'iife',
+  // The majority of these options match with the ones the CLI sets:
+  // https://github.com/angular/angular-cli/blob/0d76bf04bca6e083865972b5398a32bbe9396e14/packages/angular_devkit/build_angular/src/webpack/plugins/javascript-optimizer-worker.ts#L133.
+  treeShaking: true,
+  minifyIdentifiers: true,
+  minifySyntax: true,
+  minifyWhitespace: false,
+  pure: ['forwardRef'],
+  legalComments: 'none',
+  // ESBuild requires the `define` option to take a string-based dictionary.
+  define: convertObjectToStringDictionary(GLOBAL_DEFS_FOR_TERSER_WITH_AOT),
+  plugins: [esbuildBabelOptimizePlugin],
+};
+
+/** Converts an object to a string dictionary. */
+function convertObjectToStringDictionary(value) {
+  return Object.entries(value).reduce((result, [propName, value]) => {
+    result[propName] = String(value);
+    return result;
+  }, {});
+}
diff --git a/integration/size-test/index.bzl b/integration/size-test/index.bzl
index 54ff065ed190..2dc225c946c3 100644
--- a/integration/size-test/index.bzl
+++ b/integration/size-test/index.bzl
@@ -1,13 +1,13 @@
 load("@npm//@angular/dev-infra-private/bazel:expand_template.bzl", "expand_template")
 load("@build_bazel_rules_nodejs//:index.bzl", "nodejs_binary", "nodejs_test")
 load("@bazel_skylib//lib:paths.bzl", "paths")
-load("@npm//@bazel/rollup:index.bzl", "rollup_bundle")
+load("@npm//@bazel/esbuild:index.bzl", "esbuild")
 load("@npm//@bazel/terser:index.bzl", "terser_minified")
 load("//tools:defaults.bzl", "ng_module")
 
 """
   Performs size measurements for the specified file. The file will be built as part
-  of a `ng_module` and then will be optimized with build-optimizer, rollup and Terser.
+  of a `ng_module` and then will be optimized with esbuild, babel and terser.
 
   The resulting size will be validated against a golden file to ensure that we don't
   regress in payload size, or that we can improvements to payload size.
@@ -35,31 +35,30 @@ def size_test(name, file, deps):
         testonly = True,
         deps = [
             "@npm//@angular/core",
-            "@npm//@angular/platform-browser-dynamic",
+            "@npm//@angular/platform-browser",
         ] + deps,
     )
 
-    rollup_bundle(
+    esbuild(
         name = "%s_bundle" % name,
-        config_file = "//integration/size-test:rollup.config.js",
+        config = "//integration/size-test:esbuild_config",
         testonly = True,
-        entry_points = {
-            (index_file): "%s_bundled" % name,
-        },
+        minify = True,
+        entry_point = index_file,
         deps = [
             ":%s_lib" % name,
-            "@npm//@rollup/plugin-node-resolve",
-            "@npm//@angular-devkit/build-optimizer",
         ],
+        target = "es2020",
+        platform = "browser",
         # Link the workspace root so that files can be loaded from the workspace.
         link_workspace_root = True,
-        sourcemap = "false",
+        sourcemap = "external",
     )
 
     terser_minified(
         testonly = True,
         name = "%s_bundle_min" % name,
-        src = ":%s_bundle" % name,
+        src = "%s_bundle" % name,
         config_file = "//integration/size-test:terser-config.json",
         sourcemap = False,
     )
diff --git a/integration/size-test/material-experimental/mdc-chips/basic.ts b/integration/size-test/material-experimental/mdc-chips/basic.ts
index bf44c255ee35..53c77cbb5d60 100644
--- a/integration/size-test/material-experimental/mdc-chips/basic.ts
+++ b/integration/size-test/material-experimental/mdc-chips/basic.ts
@@ -1,5 +1,4 @@
 import {Component, NgModule} from '@angular/core';
-import {platformBrowser} from '@angular/platform-browser';
 import {MatChipsModule} from '@angular/material-experimental/mdc-chips';
 
 /**
@@ -21,5 +20,3 @@ export class TestComponent {}
   bootstrap: [TestComponent],
 })
 export class AppModule {}
-
-platformBrowser().bootstrapModule(AppModule);
diff --git a/integration/size-test/material/chips/basic.ts b/integration/size-test/material/chips/basic.ts
index 41cd96ab7096..8dc2673f5968 100644
--- a/integration/size-test/material/chips/basic.ts
+++ b/integration/size-test/material/chips/basic.ts
@@ -1,5 +1,4 @@
 import {Component, NgModule} from '@angular/core';
-import {platformBrowser} from '@angular/platform-browser';
 import {MatChipsModule} from '@angular/material/chips';
 
 /**
@@ -21,5 +20,3 @@ export class TestComponent {}
   bootstrap: [TestComponent],
 })
 export class AppModule {}
-
-platformBrowser().bootstrapModule(AppModule);
diff --git a/integration/size-test/rollup.config.js b/integration/size-test/rollup.config.js
deleted file mode 100644
index a3e283a6958b..000000000000
--- a/integration/size-test/rollup.config.js
+++ /dev/null
@@ -1,35 +0,0 @@
-const {
-  buildOptimizer,
-} = require('@angular-devkit/build-optimizer/src/build-optimizer/build-optimizer');
-const {nodeResolve} = require('@rollup/plugin-node-resolve');
-
-const buildOptimizerPlugin = {
-  name: 'build-optimizer',
-  transform: (content, id) => {
-    const {content: code, sourceMap: map} = buildOptimizer({
-      content,
-      inputFilePath: id,
-      emitSourceMap: true,
-      // Always assume side-effect free source files, except for the autogenerated
-      // module index file. The bootstrap module call should not be eliminated.
-      isSideEffectFree: !id.endsWith('_autogenerated_module_index.mjs'),
-      isAngularCoreFile: false,
-    });
-    if (!code) {
-      return null;
-    }
-    if (!map) {
-      throw new Error('No sourcemap produced by build optimizer');
-    }
-    return {code, map};
-  },
-};
-
-module.exports = {
-  plugins: [
-    buildOptimizerPlugin,
-    nodeResolve({
-      mainFields: ['es2020', 'module'],
-    }),
-  ],
-};
diff --git a/integration/size-test/terser-config.json b/integration/size-test/terser-config.json
index 000fc5b4ef43..d0af1569ea37 100644
--- a/integration/size-test/terser-config.json
+++ b/integration/size-test/terser-config.json
@@ -1,17 +1,12 @@
 {
-  "output": {
-    "ecma": "es2015",
-    "comments": false
-  },
+  "ecma": "es2020",
   "compress": {
-    "global_defs": {
-      "ngDevMode": false,
-      "ngI18nClosureMode": false,
-      "ngJitMode": false
-    },
-    "passes": 3,
+    "passes": 2,
     "pure_getters": true
   },
-  "toplevel": true,
-  "mangle": true
+  "format": {
+    "ascii_only": true,
+    "wrap_func_args": false
+  },
+  "mangle": false
 }
diff --git a/package.json b/package.json
index 2b9d24835792..76c4853811a5 100644
--- a/package.json
+++ b/package.json
@@ -67,7 +67,6 @@
   },
   "devDependencies": {
     "@angular-devkit/build-angular": "13.0.0-next.7",
-    "@angular-devkit/build-optimizer": "0.1300.0-next.7",
     "@angular-devkit/core": "13.0.0-next.7",
     "@angular-devkit/schematics": "13.0.0-next.7",
     "@angular/bazel": "13.0.0-next.15",
diff --git a/tools/angular/esbuild.config.mjs b/tools/angular/esbuild.config.mjs
index 694075b696e3..99a2bd9d8e9b 100644
--- a/tools/angular/esbuild.config.mjs
+++ b/tools/angular/esbuild.config.mjs
@@ -9,6 +9,7 @@
 import {createLinkerEsbuildPlugin} from './create_linker_esbuild_plugin.mjs';
 
 export default {
+  // Note: We support `.mjs` here as this is the extension used by Angular APF packages.
   resolveExtensions: ['.mjs', '.js'],
   format: 'esm',
   plugins: [