diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 1ac77020f..eb817102c 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -21,9 +21,8 @@ jobs:
 
       - name: Create a virtual environment
         run: git submodule init && git submodule update && python3 -m venv ./venv && . venv/bin/activate
-      - run: pip install --upgrade setuptools
-      - run: pip install -r requirements.txt
-      - run: pip install -e .
+      - run: python -m pip install build
+      - run: python -m pip install '.[test]'
       # Run our tests, but do not run the benchmark tests since they pull in libraries that do not have pypy support.
       - run: py.test --ignore tests/test_benchmark_cli.py --ignore tests/test_benchmark_spec.py
 
@@ -42,8 +41,8 @@ jobs:
 
       - name: Create a virtual environment
         run: git submodule init && git submodule update && python3 -m venv ./venv && . venv/Scripts/activate
-      - run: pip install --upgrade setuptools
-      - run: pip install -r requirements.txt
-      - run: pip install -e .
+      - run: python -m pip install build
+      - run: python -m build
+      - run: python -m pip install -e '.[test]'
       # Run our tests, but do not run the benchmark tests since they pull in libraries that do not have pypy support.
       - run: py.test --ignore tests/test_benchmark_cli.py --ignore tests/test_benchmark_spec.py
diff --git a/.github/workflows/performance-regression.yml b/.github/workflows/performance-regression.yml
index d484c5d0e..b320f814f 100644
--- a/.github/workflows/performance-regression.yml
+++ b/.github/workflows/performance-regression.yml
@@ -15,6 +15,7 @@ env:
   specs: '{command:read,format:ion_text} {command:write,format:ion_text} {command:read,format:ion_binary} {command:write,format:ion_binary}'
   test_data_id: 'generated-test-data'
   run_cli: 'python amazon/ionbenchmark/ion_benchmark_cli.py'
+  run_cli_new: 'python src-python/amazon/ionbenchmark/ion_benchmark_cli.py'
 
 
 jobs:
@@ -38,7 +39,7 @@ jobs:
           mkdir -p testData
           for test in nestedStruct nestedList sexp realWorldDataSchema01 realWorldDataSchema02 realWorldDataSchema03
           do
-            java -jar $jar_file generate -S ${{env.data_size}} --input-ion-schema $schema_dir/${test}.isl testData/${test}.10n
+            java -jar "$jar_file" generate -S "${{env.data_size}}" --input-ion-schema "$schema_dir/${test}.isl" "testData/${test}.10n"
           done
       - name: Upload test Ion Data to artifacts
         uses: actions/upload-artifact@v4
@@ -55,15 +56,12 @@ jobs:
       - uses: actions/checkout@v4
       - uses: actions/setup-python@v5
         with:
-          python-version: '3.10'
+          python-version: '3.13'
           cache: 'pip'
-          cache-dependency-path: |
-            **/requirements.txt
-            **/requirements_benchmark.txt
+          cache-dependency-path: pyproject.toml
       - run: |
-          pip install -r requirements.txt
-          [ -e "requirements_benchmark.txt" ] && pip install -r requirements_benchmark.txt # include benchmark requirements if they exist.
-          # TODO: See if there's a way to cache the ion-c build output if it hasn't changed
+          python -m pip freeze '.[test,benchmarking]' > requirements.txt # capture only dependencies.
+          python -m pip install -r requirements.txt
 
   detect-regression:
     name: Check
@@ -71,7 +69,7 @@ jobs:
     needs: [generate-test-data, prepopulate-pip-cache]
     strategy:
       matrix:
-        python-version: ['3.9', '3.11']
+        python-version: ['3.13']
         test-data: ['nestedStruct', 'nestedList', 'sexp', 'realWorldDataSchema01', 'realWorldDataSchema02', 'realWorldDataSchema03']
       fail-fast: false
     steps:
@@ -95,9 +93,7 @@ jobs:
         with:
           python-version: ${{ matrix.python-version }}
           cache: 'pip'
-          cache-dependency-path: |
-            **/requirements.txt
-            **/requirements_benchmark.txt
+          cache-dependency-path: pyproject.toml
 
       - name: Download Test Data
         id: 'download'
@@ -106,12 +102,13 @@ jobs:
           name: ${{env.test_data_id}}
 
       # Generates performance results for the previous commit
-      - name: Create a virtual environment
+      - name: Create a virtual environment for baseline
         working-directory: ./baseline
         run: |
           pip install -r requirements.txt
           [ -e "requirements_benchmark.txt" ] && pip install -r requirements_benchmark.txt # include benchmark requirements if they exist.
           pip install .
+
       - name: Run baseline performance benchmark
         id: 'baseline'
         working-directory: ./baseline
@@ -125,17 +122,15 @@ jobs:
           echo "report=$PWD/report.ion" >> "$GITHUB_OUTPUT"
 
       # Generates performance results for the current commit
-      - name: Create a virtual environment and setup the package
+      - name: Create a virtual environment for PR changes
         working-directory: ./new
-        run: |
-          pip install -r requirements.txt
-          [ -e "requirements_benchmark.txt" ] && pip install -r requirements_benchmark.txt # include benchmark requirements if they exist.
-          pip install .
+        run: pip install '.[test,benchmarking]'
+
       - name: Run new performance benchmark
         id: 'new'
         working-directory: ./new
         run: |
-          ${{env.run_cli}} spec '${{env.specs}}' -d '${{env.spec_defaults}}' \
+          ${{env.run_cli_new}} spec '${{env.specs}}' -d '${{env.spec_defaults}}' \
               -O '{input_file:"${{steps.download.outputs.download-path}}/${{ matrix.test-data }}.10n"}' \
               -o "$PWD/report.ion" -r '${{env.report_statistics}}'
           echo "::group::Ion Report"
@@ -146,4 +141,4 @@ jobs:
       # Compare results and identify regression
       - name: Detect performance regression
         working-directory: ./new
-        run: ${{env.run_cli}} compare --fail ${{steps.baseline.outputs.report}} ${{steps.new.outputs.report}} -c '${{env.compare_statistics}}'
+        run: ${{env.run_cli_new}} compare --fail ${{steps.baseline.outputs.report}} ${{steps.new.outputs.report}} -c '${{env.compare_statistics}}'
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index c30578c31..078b12c32 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -20,13 +20,10 @@ jobs:
 
       - name: Create a virtual environment
         run: git submodule init && git submodule update && python3 -m venv ./venv && . venv/bin/activate
-      - name: Install dependencies..
-        run: |
-          pip install --upgrade setuptools
-          pip install -r requirements.txt
-          pip install -e .
-      - name: Run Tests
-        run: py.test --ignore tests/test_benchmark_cli.py --ignore tests/test_benchmark_spec.py
+      - run: python -m pip install build
+      - run: python -m build .
+      - run: python -m pip install -e .
+      - run: py.test --ignore tests/test_benchmark_cli.py --ignore tests/test_benchmark_spec.py
 
   source-distribution:
     if: startsWith(github.ref, 'refs/tags/')
@@ -40,13 +37,13 @@ jobs:
       - uses: actions/checkout@v4
 
       - name: Build sdist
-        run: python3 setup.py sdist
+        run: python -m pip install build && python -m build -s
 
       - name: Upload source to Github
         uses: actions/upload-artifact@v4
         with:
           name: source
-          path: ./dist/amazon.ion-*.tar.gz
+          path: ./dist/amazon_ion-*.tar.gz
 
       - uses: aws-actions/configure-aws-credentials@v4
         with:
@@ -60,7 +57,7 @@ jobs:
 
       - name: Upload source to s3
         run: |
-          zip ion-python-source ./dist/amazon.ion-*.tar.gz
+          zip ion-python-source ./dist/amazon_ion-*.tar.gz
           aws s3 mv ion-python-source.zip ${{ secrets.AWS_SOURCE_BUCKET_URL }} --acl bucket-owner-full-control
 
       - name: Install the released source from PYPI
diff --git a/.gitignore b/.gitignore
index 21f7d7ee3..5d270e9dd 100644
--- a/.gitignore
+++ b/.gitignore
@@ -17,4 +17,4 @@
 /amazon/ion/ion-c-build/
 /temp_*.ion
 /temp_*.10n
-
+/.py-build-cmake_cache
diff --git a/.gitmodules b/.gitmodules
index 9a36d8eb9..ddbc09763 100644
--- a/.gitmodules
+++ b/.gitmodules
@@ -3,6 +3,6 @@
 	url = https://github.com/amazon-ion/ion-tests
 	branch = master
 [submodule "ion-c"]
-	path = ion-c
+	path = src/ion-c
 	url = https://github.com/amazon-ion/ion-c
 	branch = master
diff --git a/CMakeLists.txt b/CMakeLists.txt
new file mode 100644
index 000000000..edb952270
--- /dev/null
+++ b/CMakeLists.txt
@@ -0,0 +1,4 @@
+cmake_minimum_required(VERSION 3.6 FATAL_ERROR)
+project(amazon)
+
+add_subdirectory(src)
diff --git a/C_EXTENSION.md b/C_EXTENSION.md
index 02a483ee6..592a93f5f 100644
--- a/C_EXTENSION.md
+++ b/C_EXTENSION.md
@@ -76,16 +76,73 @@ b'\xe0\x01\x00\xea\xe9\x81\x83\xd6\x87\xb4\x83abc\xd3\x8a!{'
 
 ## Development
 
-Architecture of Ion Python C extension:
+The Ion Python C extension is built as part of the PEP 517 build process using py-build-cmake, and leaning on
+Ion C's existing cmake build. A revision of Ion C is included as a submodule in this repo under `src/ion-c`.
+If you would like to update the version of Ion C, simply update the submodule to point to the desired revision.
+
+The file `src/CMakeLists.txt` acts as the build script for the C extension itself, which then includes the Ion C
+codebase into the build tree.
+
+With the extension built, it will be exposed to python as `amazon._ioncmodule`. For example:
+```python
+>>> import amazon._ioncmodule as ionc
+>>> ionc.ionc_version()
+'v1.1.3 (rev: d61c09a)'
+>>>
 ```
-                                   ioncmodule.c
-                                        |
-                                        | 
-                                        ↓ 
-Ion C -------> Ion C binaries -----> setup.py ------> C extension -------------------> Ion Python simpleion module
-      compile                                  setup               import ionc module   
+
+The `amazon.ion.simpleion` module then makes use of this extension when it is available to provide more efficient
+Ion reading and writing. Importing `amazon._ioncmodule` directly can determine if it is available, however simpleion
+also provides the field `__IS_C_EXTENSION_SUPPORTED`.
+```python
+>>> import amazon.ion.simpleion as ion
+>>> ion.__IS_C_EXTENSION_SUPPORTED
+True
+>>>
+```
+
+In order to build the extension, along with the package itself, we can use python's build module:
+```python
+ion-python# python -m build .
+* Creating isolated environment: venv+pip...
+* Installing packages in isolated environment:
+  - py-build-cmake~=0.1.8
+* Getting build dependencies for sdist...
+* Building sdist...
+* Building wheel from sdist
+* Creating isolated environment: venv+pip...
+* Installing packages in isolated environment:
+  - py-build-cmake~=0.1.8
+* Getting build dependencies for wheel...
+* Building wheel...
+...
+Successfully built amazon_ion-0.13.0.tar.gz and amazon_ion-0.13.0-cp310-cp310-linux_x86_64.whl
+```
+This will build both the source wheel, and the binary wheel for the current system. Installing the module can
+be done with pip. Depending on what you're doing with the package you may want to install different dependencies.
+Different sets of optional dependencies are provided, such as `test`, and `benchmarking`. More details can be
+found in the `pyproject.toml`.
+
+To install the package and dependencies for unit tests you can run:
+```python
+ion-python# python -m pip install '.[test]'
+Processing /ion-python
+  Installing build dependencies ... done
+  Getting requirements to build wheel ... done
+  Preparing metadata (pyproject.toml) ... done
+Building wheels for collected packages: amazon_ion
+  Building wheel for amazon_ion (pyproject.toml) ... done
+  Created wheel for amazon_ion: filename=amazon_ion-0.13.0-cp310-cp310-linux_x86_64.whl size=573770 sha256=96ef01efea7519a1a38d9fc9e42139ab82125aafa328cfb4a4823458de802fa1
+  Stored in directory: /root/.cache/pip/wheels/78/55/f9/c6d69051d6a93c725251429f62d0d5b7d16d8c982a3772d666
+Successfully built amazon_ion
+Installing collected packages: amazon_ion
+  Attempting uninstall: amazon_ion
+    Found existing installation: amazon_ion 0.13.0
+    Uninstalling amazon_ion-0.13.0:
+      Successfully uninstalled amazon_ion-0.13.0
+Successfully installed amazon_ion-0.13.0
 ```
-After setup, C extension will be built and imported to simpleion module. If there are changes in `ioncmodule.c`, build the latest C extension by running `python setup.py build_ext --inplace`.
+Installing with `-e` will also allow you to update the python side of the package without having to re-install.
 
 
 ## Technical Details
diff --git a/install.py b/install.py
deleted file mode 100644
index a8aca322e..000000000
--- a/install.py
+++ /dev/null
@@ -1,205 +0,0 @@
-# Copyright 2016 Amazon.com, Inc. or its affiliates. All Rights Reserved.
-#
-# Licensed under the Apache License, Version 2.0 (the "License").
-# You may not use this file except in compliance with the License.
-# A copy of the License is located at:
-#
-#    http://aws.amazon.com/apache2.0/
-#
-# or in the "license" file accompanying this file. This file is
-# distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS
-# OF ANY KIND, either express or implied. See the License for the
-# specific language governing permissions and limitations under the
-# License.
-
-# Python 2/3 compatibility
-from __future__ import absolute_import
-from __future__ import division
-from __future__ import print_function
-
-import os
-import platform
-import shutil
-import sys
-from subprocess import check_call
-from os.path import join, abspath, isdir, dirname
-
-_PYPY = hasattr(sys, 'pypy_translation_info')
-_OS = platform.system()
-_WIN = _OS == 'Windows'
-_MAC = _OS == 'Darwin'
-_LINUX = _OS == 'Linux'
-
-_C_EXT_DEPENDENCY_DIR = abspath(join(dirname(os.path.abspath(__file__)), 'amazon/ion/ion-c-build'))
-_C_EXT_DEPENDENCY_LIB_LOCATION = abspath(join(_C_EXT_DEPENDENCY_DIR, 'lib'))
-_C_EXT_DEPENDENCY_INCLUDES_DIR = abspath(join(_C_EXT_DEPENDENCY_DIR, 'include'))
-_C_EXT_DEPENDENCY_INCLUDES_LOCATIONS = {
-    'ionc': abspath(join(_C_EXT_DEPENDENCY_INCLUDES_DIR, 'ionc')),
-    'decNumber': abspath(join(_C_EXT_DEPENDENCY_INCLUDES_DIR, 'decNumber'))
-}
-_CURRENT_ION_C_DIR = './ion-c'
-
-_IONC_REPO_URL = "https://github.com/amazon-ion/ion-c.git"
-_IONC_DIR = abspath(join(dirname(os.path.abspath(__file__)), 'ion-c'))
-_IONC_LOCATION = abspath(join(dirname(os.path.abspath(__file__)), 'ion-c', 'build', 'release'))
-_IONC_INCLUDES_LOCATIONS = {
-    'ionc': abspath(join(dirname(os.path.abspath(__file__)), 'ion-c', 'ionc', 'include', 'ionc')),
-    'decNumber': abspath(join(dirname(os.path.abspath(__file__)), 'ion-c', 'decNumber', 'include', 'decNumber'))
-}
-
-_LIB_PREFIX = 'lib'
-
-_LIB_SUFFIX_MAC = '.dylib'
-_LIB_SUFFIX_WIN = '.lib'
-_LIB_SUFFIX_LINUX = '.so'
-
-
-def _get_lib_name(name):
-    if _MAC:
-        return '%s%s%s' % (_LIB_PREFIX, name, _LIB_SUFFIX_MAC)
-    elif _LINUX:
-        return '%s%s%s' % (_LIB_PREFIX, name, _LIB_SUFFIX_LINUX)
-    elif _WIN:
-        return '%s%s' % (name, _LIB_SUFFIX_WIN)
-
-
-def _library_exists():
-    return _library_exists_helper('ionc') and _library_exists_helper('decNumber')
-
-
-def _library_exists_helper(name):
-    return os.path.exists(join(_IONC_INCLUDES_LOCATIONS[name])) \
-        and os.path.exists(join(_IONC_LOCATION, name))
-
-
-def readonly_handler(func, path, execinfo):
-    os.chmod(path, 128)
-    func(path)
-
-
-def _download_ionc():
-    try:
-        # Install ion-c.
-        if isdir(_CURRENT_ION_C_DIR):
-            shutil.rmtree(_CURRENT_ION_C_DIR, onerror=readonly_handler)
-
-        # TODO submodule does not work, need to be fixed.
-        # check_call(['git', 'submodule', 'update', '--init', '--recursive'])
-        check_call(['git', 'clone', '--recurse-submodules', _IONC_REPO_URL, 'ion-c'])
-
-        os.chdir(_CURRENT_ION_C_DIR)
-
-        # Initialize submodule.
-        check_call(['git', 'submodule', 'update', '--init'])
-
-        # Build ion-c.
-        _build_ionc()
-
-        os.chdir('../')
-        return True
-    except:
-        if isdir(_IONC_DIR):
-            shutil.rmtree(_IONC_DIR, onerror=readonly_handler)
-        print('ionc build error: Unable to build ion-c library.')
-        return False
-
-
-def _build_ionc():
-    if _WIN:
-        _build_ionc_win()
-    elif _MAC or _LINUX:
-        _build_ionc_mac_and_linux()
-
-
-def _move_ionc():
-    # move ion-c to output dir.
-    if _WIN:
-        _move_lib_win('ionc')
-        _move_lib_win('decNumber')
-    elif _MAC or _LINUX:
-        _move_lib_mac_and_linux('ionc')
-        _move_lib_mac_and_linux('decNumber')
-
-
-def _build_ionc_win():
-    # check_call('cmake -G \"Visual Studio 15 2017 Win64\"')
-    # check_call('cmake -G \"Visual Studio 16 2019\"')
-    check_call('cmake -G \"Visual Studio 17 2022\"')
-    check_call('cmake --build . --config Release --target decNumber --target ion')
-
-
-def _move_lib_win(name):
-    """
-    Move library and its include files to ion-c-build/lib and ion-c-build/include respectively.
-    """
-    for f in os.listdir(_IONC_INCLUDES_LOCATIONS[name]):
-        shutil.copy(join(_IONC_INCLUDES_LOCATIONS[name], f), _C_EXT_DEPENDENCY_INCLUDES_LOCATIONS[name])
-
-    lib_path = join(_IONC_DIR, name, 'Release', '%s%s' % (name, _LIB_SUFFIX_WIN))
-    shutil.copy(lib_path, _C_EXT_DEPENDENCY_LIB_LOCATION)
-
-
-def _build_ionc_mac_and_linux():
-    # build ion-c.
-    check_call(['./build-release.sh'])
-
-
-def _move_lib_mac_and_linux(name):
-    """
-    Move library and its include files to ion-c-build/lib and ion-c-build/include respectively.
-    """
-    for f in os.listdir(_IONC_INCLUDES_LOCATIONS[name]):
-        shutil.copy(join(_IONC_INCLUDES_LOCATIONS[name], f), _C_EXT_DEPENDENCY_INCLUDES_LOCATIONS[name])
-
-    dir_path = join(_IONC_LOCATION, name)
-    for file in os.listdir(dir_path):
-        file_path = join(dir_path, file)
-        if _LINUX:
-            if file.startswith('%s%s%s' % (_LIB_PREFIX, name, _LIB_SUFFIX_LINUX)):
-                shutil.copy(file_path, _C_EXT_DEPENDENCY_LIB_LOCATION)
-        elif _MAC:
-            if file.endswith(_LIB_SUFFIX_MAC):
-                shutil.copy(file_path, _C_EXT_DEPENDENCY_LIB_LOCATION)
-
-
-def move_build_lib_for_distribution():
-    # Create a directory to store build output.
-    if isdir(_C_EXT_DEPENDENCY_DIR):
-        shutil.rmtree(_C_EXT_DEPENDENCY_DIR, onerror=readonly_handler)
-    os.mkdir(_C_EXT_DEPENDENCY_DIR)
-    os.mkdir(_C_EXT_DEPENDENCY_LIB_LOCATION)
-    os.mkdir(_C_EXT_DEPENDENCY_INCLUDES_DIR)
-    os.mkdir(_C_EXT_DEPENDENCY_INCLUDES_LOCATIONS['ionc'])
-    os.mkdir(_C_EXT_DEPENDENCY_INCLUDES_LOCATIONS['decNumber'])
-    # Move ion-c binaries to ion-c-build
-    _move_ionc()
-
-
-def _check_dependencies():
-    try:
-        check_call(['git', '--version'])
-        check_call(['cmake', '--version'])
-        # TODO add more dependency check here.
-    except:
-        print('ion-c build error: Missing dependencies.')
-        return False
-    return True
-
-
-def _install_ionc():
-    if _PYPY:  # This is pointless if running with PyPy, which doesn't support CPython extensions anyway.
-        return False
-
-    if not _check_dependencies():
-        return False
-
-    if not _library_exists():
-        if not _download_ionc():
-            return False
-    move_build_lib_for_distribution()
-
-    return True
-
-
-if __name__ == '__main__':
-    _install_ionc()
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 000000000..aae933c3c
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,92 @@
+[project]
+name = "amazon-ion"
+readme = "README.md"
+requires-python = ">=3.8"
+license = { "file" = "LICENSE" }
+authors = [{ "name" = "Amazon Ion Team", "email" = "ion-team@amazon.com" }]
+keywords = []
+classifiers = []
+urls = { "Documentation" = "https://ion-python.readthedocs.io/en/latest/?badge=latest" }
+dependencies = [
+    "attrs==21.2.0",
+    "setuptools==71.0.0",    # Needed for jsonconversion, it seems
+    "jsonconversion==0.2.13", # 1.0.1 tightens the requirements for pytest, and 1.0.0 is broken.
+    "pyparsing==3.0.0",
+]
+dynamic = ["version", "description"]
+
+[project.optional-dependencies]
+test = [
+   "pytest==8.3.3"
+]
+benchmarking = [
+    "docopt==0.6.2",
+    "tabulate==0.9.0",
+    "simplejson~=3.18.3",
+    "six~=1.16.0",
+    "cbor~=1.0.0",
+    "cbor2~=5.4.6",
+    "python-rapidjson~=1.19",
+    "ujson~=5.7.0",
+    "protobuf>=4.0.0"
+]
+dev = [
+    "tox==3.23.1",
+    "virtualenv==20.28.0"
+]
+
+# Build System ################################################################################
+[build-system]
+requires = ["py-build-cmake~=0.1.8"]
+build-backend = "py_build_cmake.build"
+
+# py-build-cmake ##############################################################################
+#  We use CMake for our extension's build. py-build-cmake implements the build backend to build
+#  our extension, and the underlying ion-c libraries it depends on, using cmake as well as provide
+#  the mechanisms to produce the sdist as well.
+[tool.py-build-cmake.module]
+name = "amazon"
+directory = "src-python"
+
+[tool.py-build-cmake.sdist]
+include = ["CMakeLists.txt", "src/*"]
+
+[tool.py-build-cmake.cmake]
+build_type = "Release"
+source_path = "src"
+build_args = []
+install_components = ["python_module"]
+
+# cibuildwheel ################################################################################
+#  Used to build the various wheels we want to support so that our users do not need to build
+#  the extension themselves. cibuildwheel can handle building the extension for multiple python
+#  versions and architectures.
+[tool.cibuildwheel]
+before-all = "uname -a"
+
+# pytest ######################################################################################
+#  Unit testing options and support.
+[tool.pytest.ini_options]
+minversion = "6.0"
+# addopts = "-rw --strict-markers"
+testpaths = ["tests"]
+
+# tox #########################################################################################
+#  Virtual Environment Management; When using tox the envlist defined here will be used for
+#  running our default unit tests (minus benchmarking related tests). This ensures that we
+#  can easily test against supported python versions.
+[tool.tox]
+envlist = ["py3.8", "py3.9", "pypy3"] # default environments to run.
+
+[tool.tox.env_run_base]
+extras = ["test"]
+requires = ["pip >= 21.1.2", "setuptools >= 57.0.0"]
+commands = [
+   ["py.test", "--ignore", "tests/test_benchmark_cli.py", "--ignore", "tests/test_benchmark_spec.py", { replace = "posargs", extend = true}]
+]
+
+[tool.tox.env.benchmark_tests]
+extras = ["test", "benchmarking"]
+commands = [
+   ["py.test", "tests/test_benchmark_cli.py", "tests/test_benchmark_spec.py", { replace = "posargs", extend = true}]
+]
diff --git a/pytest.ini b/pytest.ini
deleted file mode 100644
index 99adee9b4..000000000
--- a/pytest.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[pytest]
-testpaths=tests
-addopts=-rw --strict
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 596b27b59..000000000
--- a/requirements.txt
+++ /dev/null
@@ -1,20 +0,0 @@
-appdirs==1.4.4
-attrs==21.2.0
-distlib==0.3.9
-filelock==3.16.1
-iniconfig==1.1.1
-jsonconversion==0.2.12
-packaging==20.9
-pluggy==0.13.1
-py==1.11.0
-pyparsing==2.4.7
-pytest==6.2.4
-pytest-runner==5.3.1
-toml==0.10.2
-tox==3.23.1
-virtualenv==20.28.0
-setuptools==72.0.0
-docopt==0.6.2
-tabulate==0.9.0
-simplejson~=3.18.3
-six~=1.16.0
diff --git a/requirements_benchmark.txt b/requirements_benchmark.txt
deleted file mode 100644
index 504fb34d7..000000000
--- a/requirements_benchmark.txt
+++ /dev/null
@@ -1,5 +0,0 @@
-cbor~=1.0.0
-cbor2~=5.4.6
-python-rapidjson~=1.19
-ujson~=5.7.0
-protobuf>=4.0.0
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index b7e478982..000000000
--- a/setup.cfg
+++ /dev/null
@@ -1,2 +0,0 @@
-[aliases]
-test=pytest
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 74ff24854..000000000
--- a/setup.py
+++ /dev/null
@@ -1,72 +0,0 @@
-# Copyright 2016 Amazon.com, Inc. or its affiliates. All Rights Reserved.
-#
-# Licensed under the Apache License, Version 2.0 (the "License").
-# You may not use this file except in compliance with the License.
-# A copy of the License is located at:
-#
-#    http://aws.amazon.com/apache2.0/
-#
-# or in the "license" file accompanying this file. This file is
-# distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS
-# OF ANY KIND, either express or implied. See the License for the
-# specific language governing permissions and limitations under the
-# License.
-
-import sys
-from setuptools import setup, find_packages, Extension
-from install import _install_ionc
-
-C_EXT = True if not hasattr(sys, 'pypy_translation_info') else False
-
-
-def run_setup():
-    if C_EXT and _install_ionc():
-        print('C extension is enabled!')
-        kw = dict(
-            ext_modules=[
-                Extension(
-                    'amazon.ion.ionc',
-                    sources=['amazon/ion/ioncmodule.c'],
-                    include_dirs=['amazon/ion/ion-c-build/include',
-                                  'amazon/ion/ion-c-build/include/ionc',
-                                  'amazon/ion/ion-c-build/include/decNumber'],
-                    libraries=['ionc', 'decNumber'],
-                    library_dirs=['amazon/ion/ion-c-build/lib'],
-                    extra_link_args=['-Wl,-rpath,%s' % '$ORIGIN/ion-c-build/lib',  # LINUX
-                                     '-Wl,-rpath,%s' % '@loader_path/ion-c-build/lib'  # MAC
-                                     ],
-                    extra_compile_args=['-std=c99'],
-                ),
-            ],
-        )
-    else:
-        print('Using pure python implementation.')
-        kw = dict()
-
-
-    setup(
-        name='amazon.ion',
-        version='0.13.0',
-        description='A Python implementation of Amazon Ion.',
-        url='http://github.com/amazon-ion/ion-python',
-        author='Amazon Ion Team',
-        author_email='ion-team@amazon.com',
-        license='Apache License 2.0',
-
-
-        packages=find_packages(exclude=['tests*']),
-        include_package_data=True,
-        namespace_packages=['amazon'],
-
-        setup_requires=[
-            'pytest-runner',
-        ],
-
-        tests_require=[
-            'pytest',
-        ],
-        **kw
-    )
-
-
-run_setup()
diff --git a/amazon/__init__.py b/src-python/amazon/__init__.py
similarity index 82%
rename from amazon/__init__.py
rename to src-python/amazon/__init__.py
index 88e019661..b1f1ce00c 100644
--- a/amazon/__init__.py
+++ b/src-python/amazon/__init__.py
@@ -12,5 +12,9 @@
 # specific language governing permissions and limitations under the
 # License.
 
-# XXX Setuptools Namespace Package
-__import__("pkg_resources").declare_namespace(__name__)
+"""
+Amazon Ion
+"""
+__version__ = "0.13.0"
+from pkgutil import extend_path
+__path__ = extend_path(__path__, __name__)
diff --git a/amazon/ion/__init__.py b/src-python/amazon/ion/__init__.py
similarity index 100%
rename from amazon/ion/__init__.py
rename to src-python/amazon/ion/__init__.py
diff --git a/amazon/ion/core.py b/src-python/amazon/ion/core.py
similarity index 100%
rename from amazon/ion/core.py
rename to src-python/amazon/ion/core.py
diff --git a/amazon/ion/equivalence.py b/src-python/amazon/ion/equivalence.py
similarity index 100%
rename from amazon/ion/equivalence.py
rename to src-python/amazon/ion/equivalence.py
diff --git a/amazon/ion/exceptions.py b/src-python/amazon/ion/exceptions.py
similarity index 100%
rename from amazon/ion/exceptions.py
rename to src-python/amazon/ion/exceptions.py
diff --git a/amazon/ion/json_encoder.py b/src-python/amazon/ion/json_encoder.py
similarity index 100%
rename from amazon/ion/json_encoder.py
rename to src-python/amazon/ion/json_encoder.py
diff --git a/amazon/ion/reader.py b/src-python/amazon/ion/reader.py
similarity index 100%
rename from amazon/ion/reader.py
rename to src-python/amazon/ion/reader.py
diff --git a/amazon/ion/reader_binary.py b/src-python/amazon/ion/reader_binary.py
similarity index 100%
rename from amazon/ion/reader_binary.py
rename to src-python/amazon/ion/reader_binary.py
diff --git a/amazon/ion/reader_managed.py b/src-python/amazon/ion/reader_managed.py
similarity index 100%
rename from amazon/ion/reader_managed.py
rename to src-python/amazon/ion/reader_managed.py
diff --git a/amazon/ion/reader_text.py b/src-python/amazon/ion/reader_text.py
similarity index 100%
rename from amazon/ion/reader_text.py
rename to src-python/amazon/ion/reader_text.py
diff --git a/amazon/ion/simple_types.py b/src-python/amazon/ion/simple_types.py
similarity index 100%
rename from amazon/ion/simple_types.py
rename to src-python/amazon/ion/simple_types.py
diff --git a/amazon/ion/simpleion.py b/src-python/amazon/ion/simpleion.py
similarity index 99%
rename from amazon/ion/simpleion.py
rename to src-python/amazon/ion/simpleion.py
index 709e072bc..f2d98c512 100644
--- a/amazon/ion/simpleion.py
+++ b/src-python/amazon/ion/simpleion.py
@@ -77,7 +77,7 @@
 from .writer_binary import binary_writer
 
 try:
-    import amazon.ion.ionc as ionc
+    import amazon._ioncmodule as ionc
     __IS_C_EXTENSION_SUPPORTED = True
 except ModuleNotFoundError:
     __IS_C_EXTENSION_SUPPORTED = False
diff --git a/amazon/ion/sliceable_buffer.py b/src-python/amazon/ion/sliceable_buffer.py
similarity index 100%
rename from amazon/ion/sliceable_buffer.py
rename to src-python/amazon/ion/sliceable_buffer.py
diff --git a/amazon/ion/symbols.py b/src-python/amazon/ion/symbols.py
similarity index 100%
rename from amazon/ion/symbols.py
rename to src-python/amazon/ion/symbols.py
diff --git a/amazon/ion/util.py b/src-python/amazon/ion/util.py
similarity index 100%
rename from amazon/ion/util.py
rename to src-python/amazon/ion/util.py
diff --git a/amazon/ion/writer.py b/src-python/amazon/ion/writer.py
similarity index 100%
rename from amazon/ion/writer.py
rename to src-python/amazon/ion/writer.py
diff --git a/amazon/ion/writer_binary.py b/src-python/amazon/ion/writer_binary.py
similarity index 100%
rename from amazon/ion/writer_binary.py
rename to src-python/amazon/ion/writer_binary.py
diff --git a/amazon/ion/writer_binary_raw.py b/src-python/amazon/ion/writer_binary_raw.py
similarity index 100%
rename from amazon/ion/writer_binary_raw.py
rename to src-python/amazon/ion/writer_binary_raw.py
diff --git a/amazon/ion/writer_binary_raw_fields.py b/src-python/amazon/ion/writer_binary_raw_fields.py
similarity index 100%
rename from amazon/ion/writer_binary_raw_fields.py
rename to src-python/amazon/ion/writer_binary_raw_fields.py
diff --git a/amazon/ion/writer_buffer.py b/src-python/amazon/ion/writer_buffer.py
similarity index 100%
rename from amazon/ion/writer_buffer.py
rename to src-python/amazon/ion/writer_buffer.py
diff --git a/amazon/ion/writer_text.py b/src-python/amazon/ion/writer_text.py
similarity index 100%
rename from amazon/ion/writer_text.py
rename to src-python/amazon/ion/writer_text.py
diff --git a/amazon/ionbenchmark/Format.py b/src-python/amazon/ionbenchmark/Format.py
similarity index 100%
rename from amazon/ionbenchmark/Format.py
rename to src-python/amazon/ionbenchmark/Format.py
diff --git a/amazon/ionbenchmark/__init__.py b/src-python/amazon/ionbenchmark/__init__.py
similarity index 100%
rename from amazon/ionbenchmark/__init__.py
rename to src-python/amazon/ionbenchmark/__init__.py
diff --git a/amazon/ionbenchmark/benchmark_runner.py b/src-python/amazon/ionbenchmark/benchmark_runner.py
similarity index 100%
rename from amazon/ionbenchmark/benchmark_runner.py
rename to src-python/amazon/ionbenchmark/benchmark_runner.py
diff --git a/amazon/ionbenchmark/benchmark_spec.py b/src-python/amazon/ionbenchmark/benchmark_spec.py
similarity index 100%
rename from amazon/ionbenchmark/benchmark_spec.py
rename to src-python/amazon/ionbenchmark/benchmark_spec.py
diff --git a/amazon/ionbenchmark/cbor_load_dump.py b/src-python/amazon/ionbenchmark/cbor_load_dump.py
similarity index 100%
rename from amazon/ionbenchmark/cbor_load_dump.py
rename to src-python/amazon/ionbenchmark/cbor_load_dump.py
diff --git a/amazon/ionbenchmark/ion_benchmark_cli.py b/src-python/amazon/ionbenchmark/ion_benchmark_cli.py
similarity index 100%
rename from amazon/ionbenchmark/ion_benchmark_cli.py
rename to src-python/amazon/ionbenchmark/ion_benchmark_cli.py
diff --git a/amazon/ionbenchmark/ion_load_dump.py b/src-python/amazon/ionbenchmark/ion_load_dump.py
similarity index 100%
rename from amazon/ionbenchmark/ion_load_dump.py
rename to src-python/amazon/ionbenchmark/ion_load_dump.py
diff --git a/amazon/ionbenchmark/json_load_dump.py b/src-python/amazon/ionbenchmark/json_load_dump.py
similarity index 100%
rename from amazon/ionbenchmark/json_load_dump.py
rename to src-python/amazon/ionbenchmark/json_load_dump.py
diff --git a/amazon/ionbenchmark/proto.py b/src-python/amazon/ionbenchmark/proto.py
similarity index 100%
rename from amazon/ionbenchmark/proto.py
rename to src-python/amazon/ionbenchmark/proto.py
diff --git a/amazon/ionbenchmark/proto_tools.py b/src-python/amazon/ionbenchmark/proto_tools.py
similarity index 100%
rename from amazon/ionbenchmark/proto_tools.py
rename to src-python/amazon/ionbenchmark/proto_tools.py
diff --git a/amazon/ionbenchmark/report.py b/src-python/amazon/ionbenchmark/report.py
similarity index 100%
rename from amazon/ionbenchmark/report.py
rename to src-python/amazon/ionbenchmark/report.py
diff --git a/amazon/ionbenchmark/sample_dist.py b/src-python/amazon/ionbenchmark/sample_dist.py
similarity index 100%
rename from amazon/ionbenchmark/sample_dist.py
rename to src-python/amazon/ionbenchmark/sample_dist.py
diff --git a/amazon/ionbenchmark/self_describing_proto.proto b/src-python/amazon/ionbenchmark/self_describing_proto.proto
similarity index 100%
rename from amazon/ionbenchmark/self_describing_proto.proto
rename to src-python/amazon/ionbenchmark/self_describing_proto.proto
diff --git a/amazon/ionbenchmark/self_describing_proto.py b/src-python/amazon/ionbenchmark/self_describing_proto.py
similarity index 100%
rename from amazon/ionbenchmark/self_describing_proto.py
rename to src-python/amazon/ionbenchmark/self_describing_proto.py
diff --git a/amazon/ionbenchmark/self_describing_proto_pb2.py b/src-python/amazon/ionbenchmark/self_describing_proto_pb2.py
similarity index 100%
rename from amazon/ionbenchmark/self_describing_proto_pb2.py
rename to src-python/amazon/ionbenchmark/self_describing_proto_pb2.py
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
new file mode 100644
index 000000000..c78354f59
--- /dev/null
+++ b/src/CMakeLists.txt
@@ -0,0 +1,26 @@
+cmake_minimum_required(VERSION 3.6 FATAL_ERROR)
+project(ion)
+
+find_package(Python3 REQUIRED COMPONENTS Development.Module)
+
+set(IONC_BUILD_TESTS OFF CACHE BOOL "disable ionc test builds")
+add_subdirectory(ion-c/ EXCLUDE_FROM_ALL)
+
+Python3_add_library(_ioncmodule MODULE "ioncmodule.c")
+
+if (MSVC)
+   target_link_libraries(_ioncmodule PRIVATE objlib decNumber_static)
+else()
+   # We need to link against libm explicitly for *nix.
+   target_link_libraries(_ioncmodule PRIVATE objlib decNumber_static m)
+endif()
+
+target_include_directories(_ioncmodule PUBLIC
+   $<BUILD_INTERFACE:${CMAKE_CURRENT_SOURCE_DIR}/ion-c/decNumber/include>
+   $<BUILD_INTERFACE:${CMAKE_CURRENT_SOURCE_DIR}/ion-c/ionc/include>
+)
+
+install(TARGETS _ioncmodule objlib
+        EXCLUDE_FROM_ALL
+        COMPONENT python_module
+        DESTINATION ${PY_BUILD_CMAKE_MODULE_NAME})
diff --git a/amazon/ion/_ioncmodule.h b/src/_ioncmodule.h
similarity index 93%
rename from amazon/ion/_ioncmodule.h
rename to src/_ioncmodule.h
index e991ec5ce..0e681b95e 100644
--- a/amazon/ion/_ioncmodule.h
+++ b/src/_ioncmodule.h
@@ -2,8 +2,8 @@
 #define _IONCMODULE_H_
 
 #include "structmember.h"
-#include "decimal128.h"
-#include "ion.h"
+#include "decNumber/decimal128.h"
+#include "ionc/ion.h"
 
 PyObject* ionc_init_module(void);
 iERR ionc_write_value(hWRITER writer, PyObject* obj, PyObject* tuple_as_sexp);
diff --git a/ion-c b/src/ion-c
similarity index 100%
rename from ion-c
rename to src/ion-c
diff --git a/amazon/ion/ioncmodule.c b/src/ioncmodule.c
similarity index 99%
rename from amazon/ion/ioncmodule.c
rename to src/ioncmodule.c
index e66e0f7d1..45155f5e1 100644
--- a/amazon/ion/ioncmodule.c
+++ b/src/ioncmodule.c
@@ -1531,6 +1531,12 @@ PyObject* ionc_read(PyObject* self, PyObject *args, PyObject *kwds) {
     return exception;
 }
 
+PyObject *ionc_version() {
+   char const *version = ion_version_full();
+   PyObject *version_obj = PyUnicode_FromString(version);
+   return version_obj;
+}
+
 /******************************************************************************
 *       Initial module                                                        *
 ******************************************************************************/
@@ -1541,6 +1547,7 @@ static char ioncmodule_docs[] =
 static PyMethodDef ioncmodule_funcs[] = {
     {"ionc_write", (PyCFunction)ionc_write, METH_VARARGS | METH_KEYWORDS, ioncmodule_docs},
     {"ionc_read", (PyCFunction)ionc_read, METH_VARARGS | METH_KEYWORDS, ioncmodule_docs},
+    {"ionc_version", (PyCFunction)ionc_version, METH_NOARGS, ioncmodule_docs},
     {NULL}
 };
 
@@ -1668,7 +1675,7 @@ static PyObject* init_module(void) {
 }
 
 PyMODINIT_FUNC
-PyInit_ionc(void)
+PyInit__ioncmodule(void)
 {
     return init_module();
 }
diff --git a/tests/test_benchmark_cli.py b/tests/test_benchmark_cli.py
index 913b74cbb..9d948b53a 100644
--- a/tests/test_benchmark_cli.py
+++ b/tests/test_benchmark_cli.py
@@ -17,7 +17,7 @@ def generate_test_path(p):
 
 def run_cli(c):
     import subprocess
-    cmd = ["python", abspath(join(dirname(os.path.abspath(__file__)), '../amazon/ionbenchmark/ion_benchmark_cli.py'))] + c
+    cmd = ["python", abspath(join(dirname(os.path.abspath(__file__)), '../src-python/amazon/ionbenchmark/ion_benchmark_cli.py'))] + c
     proc = subprocess.Popen(cmd, stdout=subprocess.PIPE, text=True)
     error_code = proc.wait()
     (out, err) = proc.communicate()
diff --git a/tests/test_vectors.py b/tests/test_vectors.py
index 315d99db4..431a4f91c 100644
--- a/tests/test_vectors.py
+++ b/tests/test_vectors.py
@@ -33,6 +33,9 @@
 
 PYPY = hasattr(sys, 'pypy_translation_info')
 
+if hasattr(sys, 'set_int_max_str_digits'):
+    sys.set_int_max_str_digits(10000) # See: https://github.com/python/cpython/issues/95778
+
 # This file lives in the tests/ directory. Up one level is tests/ and up another level is the package root, which
 # contains the vectors/ directory.
 _VECTORS_ROOT = abspath(join(abspath(__file__), u'..', u'..', u'vectors', u'iontestdata'))
diff --git a/tox.ini b/tox.ini
deleted file mode 100644
index 02950f008..000000000
--- a/tox.ini
+++ /dev/null
@@ -1,8 +0,0 @@
-[tox]
-envlist = py37,py38,py39,pypy3
-
-[testenv]
-requires= pip >= 21.1.2
-  setuptools >= 57.0.0
-deps=-rrequirements.txt
-commands={posargs:py.test}