diff --git a/src/Runner.jl b/src/Runner.jl
index 9cdb3217..f42b1fee 100644
--- a/src/Runner.jl
+++ b/src/Runner.jl
@@ -336,9 +336,9 @@ function generate_compiler_wrappers!(platform::AbstractPlatform; bin_path::Abstr
         return flags
     end
 
-    function min_macos_version_flag(p::AbstractPlatform)
-        # Ask compilers to compile for a minimum macOS version
-        return "-mmacosx-version-min=$(macos_version(p))"
+    function min_macos_version_flags()
+        # Ask compilers to compile for a minimum macOS version, targeting that SDK.
+        return ("-mmacosx-version-min=\${MACOSX_DEPLOYMENT_TARGET}", "-Wl,-sdk_version,\${MACOSX_DEPLOYMENT_TARGET}")
     end
 
     function add_system_includedir(flags::Vector{String})
@@ -405,7 +405,7 @@ function generate_compiler_wrappers!(platform::AbstractPlatform; bin_path::Abstr
                 # `clang` as a linker (and we have no real way to detect that in the wrapper), which will
                 # cause `clang` to complain about compiler flags being passed in.
                 "-Wno-unused-command-line-argument",
-                min_macos_version_flag(p),
+                min_macos_version_flags()...,
             ])
         end
         sanitize_compile_flags!(p, flags)
@@ -454,7 +454,7 @@ function generate_compiler_wrappers!(platform::AbstractPlatform; bin_path::Abstr
         if gcc_version.major in (4, 5)
             push!(flags, "-Wl,-syslibroot,/opt/$(aatriplet(p))/$(aatriplet(p))/sys-root")
         end
-        push!(flags, min_macos_version_flag(p))
+        append!(flags, min_macos_version_flags())
         return flags
     end
 
diff --git a/test/runners.jl b/test/runners.jl
index 609ef6b5..0d08503a 100644
--- a/test/runners.jl
+++ b/test/runners.jl
@@ -398,6 +398,32 @@ end
             @test split(String(read(iobuff)), "\n")[2] == ""
         end
     end
+
+    @testset "macOS SDK setting" begin
+        mktempdir() do dir
+            platform = Platform("x86_64", "macos")
+            test_script = raw"""
+            set -e
+            prog='int main(void) { return 0; }'
+            echo "${prog}" | clang -x c - -o test-clang
+            otool -lV test-clang | grep sdk
+            # Set `MACOSX_DEPLOYMENT_TARGET` to override the value of the SDK
+            export MACOSX_DEPLOYMENT_TARGET=10.14
+            echo "${prog}" | gcc -x c - -o test-gcc
+            otool -lV test-gcc | grep sdk
+            """
+            cmd = `/bin/bash -c "$(test_script)"`
+            ur = preferred_runner()(dir; platform=platform, allow_unsafe_flags=false)
+            iobuff = IOBuffer()
+            @test run(ur, cmd, iobuff; tee_stream=devnull)
+            seekstart(iobuff)
+            lines = readlines(iobuff)
+            # Make sure the SDK for this platform is set to 10.10, instead of other wrong
+            # values, and that we can set `MACOSX_DEPLOYMENT_TARGET` to control the value.
+            @test contains(lines[end - 1], r"^ +sdk 10\.10$")
+            @test contains(lines[end], r"^ +sdk 10\.14$")
+        end
+    end
 end
 
 @testset "Shards" begin